large animal model
Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large animal model
... any large-animal or human ...a large-animal model and suggest that chemoprotection can also be used to enhance allogeneic stem cell ...
9
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis
... ovine model of collagen-induced arthritis (CIA) produces a reproducible model of inflammatory arthritis in hock joints over 2 weeks and this can be used to evalu- ate clinical signs of lameness, synovial ...
13
Effects of N-acetyl-L-cysteine on Postoperative Intrabdominal Adhesion in a Large Animal Model
... in large animal model to our knowledge has never been ...in large animal when administered ...appropriate animal model for quickly and effectively extrapolation of results ...
10
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large animal model
... These studies in miniature swine provide the first evi- dence for donor-specific tolerance induced by the mixed chimerism approach in a large-animal model. Donor skin graft survival was significantly ...
10
Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model
... In summary, labelled MAPCs showed different biodis- tribution patterns and retention in the lungs after EB and intravenous administration in our ARDS sheep model. Despite these findings and the lower dose used by ...
11
Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle in a Large Animal Model
... Cheetham, J., Perkins, J. D., Jarvis, J. C., Cercone, M., Maw, M., Hermanson, J. W., Mitchell, L. M., Piercy, R. J. and Ducharme, N. G. (2015), Effects of Functional Electrical Stimulation on Denervated Laryngeal Muscle ...
26
Resuscitation speed affects brain injury in a large animal model of traumatic brain injury and shock
... Food was withheld the night before surgery, but access to water was allowed. Preanesthesia was administered with an intramuscular injection of Tiletamine/Zolazepam (Telazol, 50 mg/ml), 8 mg/kg (Fort Dodge Animal ...
10
Left ventricular twist is load-dependent as shown in a large animal model with controlled cardiac load
... this model and these findings is that the model separates load conditions from ventricular ...this model allowed assessment of load effects from beat to beat also in the setting of experimentally ...
9
Direct Assessment of Respiratory and Cardiac Function and Reserve Capacity in a Large Animal Model of Duchenne Muscular Dystrophy.
... Current non-invasive measures that can be performed at multiple time points range from the more subjective, such as the composite clinical score – where a number of clinical markers are assigned a number by the clinician ...
123
A Novel Technique for the Measurement of CBF and CBV with Robot Arm Mounted Flat Panel CT in a Large Animal Model
... Size differences between CBF and CBV lesions were measured at both time points, and CBV lesions were larger after 3 hours than immediately after surgery. These size differences of the CBV le- sions were significant with ...
6
Generation of Severe Combined Immunodeficient (SCID) Pigs: A Novel Large Animal Model for Human Stem Cell Research.
... The Piedrahita Laboratory has a special interest in utilizing humanized pigs to support the growth of human livers for transplantation. SCID mice can bearing “humanized” liver recapitulate human-type metabolic responses ...
187
Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis
... [1]. Animal models also largely fail to create the progressive nature of fibrosis seen in IPF where the pathology and lung function of IPF patients deteriorate relatively rapidly after initial diagnosis [4, ...in ...
15
Mixed chimerism and tolerance without whole body irradiation in a large animal model
... Mixed hematopoietic chimerism may provide a treatment for patients with nonmalignant hemato- logic diseases, and may tolerize patients to organ allografts without requiring chronic immunosup- pression. However, the ...
12
Retroviral mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow
... Demonstration of sustained long-term expression of genes transferred into hematopoietic stem cells by retroviral vectors in a large animal model may also provide additional confirmation [r] ...
8
Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs
... a large animal ...useful large animal model of atherosclerosis ...a large animal model of atherosclerosis comparable to humans and to investigate the extent and ...
10
Multimodal silica nanoparticles are effective cancer targeted probes in a model of human melanoma
... Further, the sensitive, real-time detection and imaging of lymphatic drainage patterns, particle clearance rates, nodal metastases, and differential tumor burden in a large-animal model [r] ...
14
Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical
... imaging, large animal models have rather sim- ilar possibilities as humans with LBP: radiography, fluoroscopy, discog- raphy, computer tomography (CT), and magnetic resonance imaging ...in animal ...
19
Dual energy X ray absorptiometry derived bone quantity in an ovine model of osteoporosis
... The ovariectomised sheep was initially thought a suitable large animal model for the study of human osteoporosis. However to date, in and ex-vivo studies of post- ovariectomy ovine bone density ...
254
A large animal neuropathic pain model in sheep: a strategy for improving the predictability of preclinical models for therapeutic development
... that only the common peroneal nerve is injured. A clear advantage of using a large animal model such as sheep is the similarity in body size to humans. This allows us to use clinical sensory testing ...
10
Ovine model of neuropathic pain for assessing mechanisms of spinal cord stimulation therapy via dorsal horn recordings, von Frey filaments, and gait analysis
... chronic model of neuropathic pain that avoids motor deficits present in prior large animal ...This large animal model has allowed us to implant clinical grade SCS hardware, which ...
16