latency-associated nuclear antigen
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65
... Latency-associated nuclear antigen 1 (LANA-1) of Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major viral latent protein and functions as a multifaceted ...repressed ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through cis-Acting Terminal Repeat (TR) Sequence and Specifically Binds TR DNA
... KSHV latency-associated nuclear antigen (LANA1) is necessary and sufficient for persistence of artificial episomes containing specific KSHV ...
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Acetylation of the Latency-Associated Nuclear Antigen Regulates Repression of Kaposi's Sarcoma-Associated Herpesvirus Lytic Transcription
... Reactivation of the Kaposi’s sarcoma-associated herpesvirus (KSHV) lytic cycle can be initiated by tran- scription activation of the ORF50 immediate early gene (Rta). We show that ORF50 transcription is actively ...
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Identification of the gene encoding the major latency associated nuclear antigen of the Kaposi's sarcoma associated herpesvirus
... the latency-associated nuclear antigen (LANA) expressed in B cell lines infected with Kaposi's sarcoma-associated herpesvirus ...punctate nuclear staining pattern reminiscent of ...
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The latency associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma
... KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and ...
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DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s ...The latency-associated nuclear antigen (LANA) is highly expressed in these malignancies ...
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Reduction of Kaposi’s Sarcoma-Associated Herpesvirus Latency Using CRISPR-Cas9 To Edit the Latency-Associated Nuclear Antigen Gene
... the latency-associated nuclear antigen (LANA) is absolutely required in the maintenance, replication, and segregation of KSHV episomes during mitosis, which makes LANA an ideal target for ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
... The latency-associated nuclear antigen (LANA) of Kaposi’s sarcoma-associated herpesvirus (KSHV) is required for viral episome maintenance in host cells during latent ...
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... 44). Latency is characterized by the expression of a small subset of viral genes (12, 25, 26, ...The latency-associated nuclear antigen (LANA) has been detected in almost all ...
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Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is the likely etiological agent of Kaposi’s sarcoma and primary effusion lymphoma. Common to these malignancies is that ...
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Characterization of the Interaction between Latency-Associated Nuclear Antigen and Glycogen Synthase Kinase 3β
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma, primary effusion lym- phoma, and multicentric Castleman’s disease. The latency- associated nuclear ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors
... Hypoxia and hypoxia-inducible factors (HIFs) play an important role in the Kaposi’s sarcoma-associated herpesvirus (KSHV) life cycle. In particular, hypoxia can activate lytic replication of KSHV and specific ...
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... that latency-associated nuclear antigen (LANA), a multifunctional protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) that is found in Kaposi’s sarcoma tumors, upregulates ...
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Definition of Sequence Requirements for Latency-Associated Nuclear Antigen 1 Binding to Kaposi's Sarcoma-Associated Herpesvirus DNA
... Latency-associated nuclear antigen 1 (LANA1) (21, 22, 29), encoded by one of a small number of viral genes expressed in latent infection, is necessary and sufficient for KSHV episome ...
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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Permits Replication of Terminal Repeat-Containing Plasmids
... strongly associated with neoplasms of lymphoid (primary effusion lymphoma, multicen- tric Castleman’s disease) and endothelial (Kaposi’s sarcoma) origin (6, ...the latency-associated nuclear ...
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Induction of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen by the Lytic Transactivator RTA: a Novel Mechanism for Establishment of Latency
... maherpesvirus associated with a number of human malignan- cies, which include Kaposi’s sarcoma, primary effusion lym- phoma, and multicentric Castleman’s disease (5, 8, 9, 54, 56, ...the ...
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Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication
... Latency-associated nuclear antigen (LANA) is a conserved, multifunctional protein encoded by members of the rhadinovirus subfamily of gammaherpesviruses, including Kaposi ...
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Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes
... is associated with all forms of Kaposi’s sarcoma, primary effusion lymphoma (PEL), and some forms of multicentric Castleman’s disease (6, 9, 15, 16, ...for latency-associated nuclear ...
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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing Cells
... is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s ...The latency-associated nuclear antigen (LANA) is a multi- functional protein that is ...
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Kaposi's Sarcoma-Associated Herpesvirus Reactivation Is Regulated by Interaction of Latency-Associated Nuclear Antigen with Recombination Signal Sequence-Binding Protein Jκ, the Major Downstream Effector of the Notch Signaling Pathway
... of latency minimizes the number of viral epitopes that are presented by infected cells to cytotoxic T lymphocytes and so contributes to the ability of the virus to escape immune surveillance and establishment of ...
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