LDL receptor
Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor deficient mice
... Animals were trained on a treadmill with individual lanes designed for small animals, without electrical stimulation (Gesan, Sao Paulo-SP, Brazil). One week before starting the AET program, the mice were subjected to a ...
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Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice
... C57BL/6J LDL receptor knockout (LDLr KO) mice were obtained from The Jackson Laboratory as mating pairs and bred at the Gorlaeus Laboratories, Leiden, The ...
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The role of the LDL receptor in apolipoprotein B secretion
... To optimize the fit of the data, a delay compartment was introduced into the model; compartment 8 represents a delay in the time required to observe full-length apoB in the media. Because apoB100 radioactivity appeared ...
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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
... proliferator–activated receptor γ (PPARγ) is a nuclear receptor that regulates fat-cell development and glucose homeostasis and is the molecular target of a class of insulin-sensitizing agents used for the ...
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Lipoprotein clearance mechanisms in LDL receptor deficient "Apo B48 only" and "Apo B100 only" mice
... and LDL cholesterol levels were higher in Ldlr-/-Apob48/48 mice than in Apob48/48 mice, indicating that the LDL receptor plays a significant role in the removal of apo-B48-containing ...the ...
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Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
... steroidogenic tissues, is also expressed in atheroscle- rotic lesions (14, 15), where it serves as a major regu- lator of the cholesterol ester cycle in macrophages. ACAT2 (16–18) is expressed in the liver and intestine, ...
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Truncated apo B 70 5–containing lipoproteins bind to megalin but not the LDL receptor
... a receptor-mediated process, especially via the LDL receptor–mediated pathway, which plays a pivotal role in determining plasma cholesterol homeostasis in humans and other species ...of LDL ...
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Atherogenesis and metabolic dysregulation in LDL receptor–knockout rats
... Atherosclerosis is the major underlying cause of peripheral artery disease, stroke, and ischemic heart disease. It is characterized by focal thickening and narrowing of the lumen of blood vessels due to the formation of ...
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LDL receptor expression on T lymphocytes in old patients with Down syndrome
... in LDL receptor expression was not correlated with high LDL serum levels or total choles- ...in LDL; LPC may promote the start of an immune response and atherosclerosis may be the most extreme ...
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Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels
... circulating LDL levels primarily by altering receptor-dependent LDL uptake in the ...of receptor- dependent LDL transport in the liver were correlated with LDL receptor ...
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Accumulation of "small dense" low density lipoproteins (LDL) in a homozygous patients with familial defective apolipoprotein B 100 results from heterogenous interaction of LDL subfractions with the LDL receptor
... of LDL-1 to 3 were normal. The LDL receptor-mediated uptake of LDL-1 and LDL-2 could not be distinguished from normal ...LDL. LDL-3 and LDL-4 displayed reduced ...
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Sequence variation in the LDL receptor gene, and its effect on plasma lipid levels
... human LDL receptor cDNA driven by the SV40 ...the LDL receptor cDNA (containing the 3' part of the LDL receptor gene including exon 8 as shown in Figure ...
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Modulation by Insulin of the Co Localized LDL Receptor in Normal and Type I Diabetic Subjects
... maintains LDL receptors at highly expressed state in Type-1 diabetic people; yet Type-1 dia- betics are liable of having higher plasma LDL ...active LDL receptor in such ...and LDL ...
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Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor deficient mice
... Using LDL receptor-deficient mice, we now show that atheroma development depends on M-CSF concentration, as not only did homozygous osteopetrotic (op/op) mice have dramatically reduced lesions ...
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PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
... and the LDL receptor (8, 9), which suggests that these cells are relatively cholesterol deficient. Adipocytes normally contain a significant amount of free cholesterol and express a number of cholesterol ...
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In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene
... rabbit LDL receptor gene was used for treatment, the results strongly suggest that the elevations of plasma HDL cholesterol and apo AI were secondary to a reduction in plasma total cholesterol in the ...
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Role of hesperetin in LDL receptor expression in hepatoma HepG2 cells
... hepatic LDL-c catabolism relies on the activity of the LDL receptor (LDLr) to maintain a steady- state plasma concentration of LDL-c ...most LDL-receptor abundant organ and ...
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Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice
... to the EC layer (day 0). After 7 days of culture, samples were fixed with 10% formalin, embedded in paraffin, and sectioned (10 µm) for immunohistochemical study. Sections were incubated with primary antibod- ies: F4/80 ...
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The Effects of Lipophilic Antioxidants on the Affinity of LDL to Its Receptor: A Model for Prevention of Atherogenesis
... its receptor is very important, because most of LDL- uptake pathway is done by the LDL receptor and the change in size of LDL particle and the modification in its components may affects ...
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Receptor mediated Catabolism of Low Density Lipoprotein in Man QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN
... of LDL in the presence of cyanoborohydride irreversibly blocks the lysine residues of ...Glucosylated LDL (GLC-LDL) was not degraded by the LDL receptor of fibroblasts, and its ...
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