LDL receptor deficient mice
Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor deficient mice
... ) mice lacking mac- rophage colony-stimulating factor (M-CSF) have revealed an inhibition of atherosclerosis development in the apolipo- protein E (apo E)-deficient model and in a diet-induced ...Using ...
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Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor deficient mice
... the mice were subjected to a treadmill adaptation protocol in an attempt to minimize potential stress; this consisted of daily runs beginning at 10 m/ min for 10 min on the first day and was progressively ...
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A leukocyte homologue of the IL 8 receptor CXCR 2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor deficient mice
... shared receptor, CXCR-2, also can be expressed at sites of chronic ...Atherosclerosis-susceptible LDL receptor–defi- cient mice were irradiated, successfully repopulated with bone marrow cells ...
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Inhibition of NF κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice
... used LDL receptor–deficient mice with a macrophage-restricted deletion of IκB kinase 2 (IKK2), which is essen- tial for NF-κB activation by proinflammatory ...These mice showed ...
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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
... These mice, in addition to being hypercholes- terolemic, were obese, hypertriglyceridemic, and insulin resistant. They thus exhibit clinical features of many human diabetic patients who are candidates for ...
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Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1and ApoE
... ME) mice (both more than 7 times backcrossed onto a C57BL/6J background) were mated to generate F1 ...(WT) mice, which were used as donors for the bone marrow ...donor mice were anaesthetized ...
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Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice
... Although not conclusive, our results suggest several possible mechanisms by which Cat S may contribute to lesion formation. First, Cat S, one of the most potent mammalian elastases (40), remains active at neutral pH (18) ...
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Inducible inactivation of hepatic LRP gene by cre mediated recombination confirms role of LRP in clearance of chylomicron remnants
... adult mice. Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the ...the LDL ...
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Novel experimental therapies for atherosclerosis : a genomics based approach
... observed. This indicates that no additional CD99 expressing leukocytes were recruited and that the cellular composition of the examined vessels after Western type diet or chow diet feeding was not changed (data not ...
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Oxidation of the zinc thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
... disruption of the otherwise SDS-resistant eNOS dimers occurs under reducing conditions. eNOS catalytic activity is exquisitely sensitive to ONOO – , which decreases NO synthesis and increases superoxide anion (O 2 .– ) ...
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Nicolaou, Alexandros (2019): Identification of novel atherosclerosis modifiers in mice. Dissertation, LMU München: Medizinische Fakultät
... Wild-type mice are actually resistant to spontaneous atherosclerotic lesion ...species, mice have an antiatherogenic lipoprotein profile with high levels of High-density lipoproteins (HDL) and low levels of ...
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Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene
... oxidized LDL on Kupffer cells remains ...oxidized LDL receptors, including the FcgIIB receptor (20), CD36 (21), SR-BI (22), and macrosialin, or its human homologue, CD68 ...oxidized LDL bound ...
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MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
... efferocytosis receptor c- Mer tyrosine kinase (MerTK) reduces efferocytosis and promotes plaque necrosis and defective ...fat-fed LDL receptor–deficient (Ldlr –/– ) mice whose myeloid ...
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The Microbiota Promotes Arterial Thrombosis in Low Density Lipoprotein Receptor Deficient Mice
... the mice fed CD (triangles) and HFD (circles) is color coded (females [red] and males ...from mice fed HFD versus CD were compared by Student t tests, and values that were significantly different are ...
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Lipoprotein clearance mechanisms in LDL receptor deficient "Apo B48 only" and "Apo B100 only" mice
... mice developed hypercholesterolemia and hypertriglyceri- demia without an increase in apo-B100 levels. The second component leads to the appearance of larger and more buoy- ant lipoproteins in the plasma, perhaps ...
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Generation and characterization of urokinase receptor deficient mice
... rophages. This again might be explained by the action of u-PA secreted in the medium during the assay. In addition, the con- tribution of plasminogen-independent proteolytic activity might obscure possible differences ...
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LDL receptor–related protein mediates cell surface clustering and hepatic sequestration of chylomicron remnants in LDLR deficient mice
... normal mice, there was clustering of the chylomicron remnants on the cell surface in the space of ...of receptor-associated protein, an inhibitor of ...
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Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
... ACAT1-deficient mice (13) with atherosclerosis-susceptible strains such as apoE knockout mice (20) and LDL receptor–deficient (LDLR –/– ) mice ...
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Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
... chemokine receptor 1–defi- cient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD (see the related article beginning on page ...
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Transgenic rescue of insulin receptor–deficient mice
... knockout mice can be explained by the presence of compensatory pathways based on muscle contraction (43) and IGF1 receptor signaling ...L1 mice will allow us to draw a more definitive conclusion as ...
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