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lecithin-cholesterol acyltransferase

Two different allelic mutations in the lecithin cholesterol acyltransferase gene associated with the fish eye syndrome  Lecithin cholesterol acyltransferase (Thr123    Ile) and lecithin cholesterol acyltransferase (Thr347    Met)

Two different allelic mutations in the lecithin cholesterol acyltransferase gene associated with the fish eye syndrome Lecithin cholesterol acyltransferase (Thr123 Ile) and lecithin cholesterol acyltransferase (Thr347 Met)

... (HDL) cholesterol was reduced at ...plasma cholesterol esterification rate was slightly reduced at 51 nmol/ml per h (control subjects: 61-106 nmol/ml per h), whereas lecithin-cholesterol ...

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Original Article Advanced membranous nephropathy-like lesion in a Chinese patient with familial lecithin-cholesterol acyltransferase deficiency

Original Article Advanced membranous nephropathy-like lesion in a Chinese patient with familial lecithin-cholesterol acyltransferase deficiency

... Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme for the esterification of cholesterol in circulating plasma lipoproteins that pro- motes the maturation of discoidal pre-high- ...

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Markedly accelerated catabolism of apolipoprotein A II (ApoA II) and high density lipoproteins containing ApoA II in classic lecithin: cholesterol acyltransferase deficiency and fish eye disease

Markedly accelerated catabolism of apolipoprotein A II (ApoA II) and high density lipoproteins containing ApoA II in classic lecithin: cholesterol acyltransferase deficiency and fish eye disease

... Classic complete lecithin:cholesterol acyltransferase LCAT deficiency and Fish-eye disease partial LCAT deficiency are genetic syndromes associated with markedly decreased plasma levels [r] ...

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Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency  Six newly identified defective alleles further contribute to the structural heterogeneity in this disease

Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency Six newly identified defective alleles further contribute to the structural heterogeneity in this disease

... lecithin:cholesterol acyltransferase (LCAT) deficiency in six probands from five families originating from four different countries was confirmed by the absence or near absence of LCAT ...unesterified ...

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Radioimmunoassay of human plasma lecithin cholesterol acyltransferase

Radioimmunoassay of human plasma lecithin cholesterol acyltransferase

... A sensitive and precise competitive-displacement double-antibody radioimmunoassay was developed for the human plasma enzyme lecithin-cholesterol acyltransferase (LCAT; Ec 2.3 1.43). The ability of ...

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Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits  In vivo apolipoprotein A I catabolism is delayed in a gene dose dependent manner

Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits In vivo apolipoprotein A I catabolism is delayed in a gene dose dependent manner

... Lecithin cholesterol acyltransferase (LCAT) is an enzyme involved in the intravascular metabolism of high density lipoproteins ...HDL cholesterol concentrations (mg/dl), respectively, were ...

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Expression of human lecithin cholesterol acyltransferase in transgenic mice  Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism

Expression of human lecithin cholesterol acyltransferase in transgenic mice Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism

... Human (Hu) lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the plasma metabolism of cholesterol. To assess the effects of increased plasma levels of LCAT, four lines of ...

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Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins

Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins

... familial lecithin: cholesterol acyltransferase (LCAT) deficiency have been characterized by gel filtration, analytical ultracentrifugation, and gel electrophoresis, and their relative content of ...

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Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency

Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency

... Familial lecithin cholesterol acyltransferase (LCAT) deficiency (FLD), is a rare monogenic disease, characterized by abnormal lipid profile, corneal opacities, anemia and renal disease which ...

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Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by electron microscopy

Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by electron microscopy

... The low density lipoproteins (LDL) of d 1.019-1.063 g/ml of patients with familial lecithin: cholesterol acyltransferase (LCAT) deficiency show marked heterogeneity when viewed with the electron ...

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Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study

Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study

... lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic ...of lecithin cholesterol acyltransferase (LCAT) gene ...

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A frameshift mutation in the human apolipoprotein A I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol acyltransferase deficiency, and corneal opacities

A frameshift mutation in the human apolipoprotein A I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol acyltransferase deficiency, and corneal opacities

... HDL cholesterol but not of coronary artery disease, thus clinically resembling fish eye ...reduced lecithin: cholesterol acyltransferase (LCAT) activity in plasma led to sequence analysis of ...

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Fish eye syndrome: a molecular defect in the lecithin cholesterol acyltransferase (LCAT) gene associated with normal alpha LCAT specific activity  Implications for classification and prognosis

Fish eye syndrome: a molecular defect in the lecithin cholesterol acyltransferase (LCAT) gene associated with normal alpha LCAT specific activity Implications for classification and prognosis

... specific activities assayed using an HDL-like proteoliposome substrate were 12.7-25.7 nmol/micrograms (19.5 +/- 1.8 in controls). In addition, significant residual cholesterol esterification was present in ...

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The role of lecithin: cholesterol acyltransferase for lipoprotein (a) assembly  Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma

The role of lecithin: cholesterol acyltransferase for lipoprotein (a) assembly Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma

... Normal LDL, LDL from a nomolipemic donor, in the absence or the presence of detergent Tween20 or NaCl; GS/LDL density particles, LDL floating particles from the homozygous LCAT-D individ[r] ...

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Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia

Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia

... We carried out a search of the p.V333 M and p.M404 V mutations through PCR-RFLP in those participants of the GOCS cohort with the lowest levels of HDL-cholesterol (< 40 mg/dL). In 57 subjects who met this ...

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A comparative study of lipid profile in patients with and without infective hepatitis

A comparative study of lipid profile in patients with and without infective hepatitis

... biliary cholesterol into circulation, increased hepatic synthesis of cholesterol, decreased plasma lecithin cholesterol acyltransferase activity, regurgitation of biliary ...

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ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED DIABETIC RATS

ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED DIABETIC RATS

... profiles, lecithin: cholesterol acyltransferase (LCAT) and paraoxonase (PON1) activities and liver and kidney antioxidant status, in streptozotocin-induced diabetic ...total cholesterol, ...

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IN VITRO AND IN VIVO EVALUATION OF DIRECTLY COMPRESSED TABLETS OF SIMVASTATIN WITH SOY LECITHIN

IN VITRO AND IN VIVO EVALUATION OF DIRECTLY COMPRESSED TABLETS OF SIMVASTATIN WITH SOY LECITHIN

... Soy lecithin (F2) and MCC (F3) to evaluate Soy Lecithin as a direct compression vehicle and a comparative in-vivo evaluation to observe potential anti-cholesterol activity with the Soy ...

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A Comparative Study of the Lipids of the Vertebrate Central Nervous System

A Comparative Study of the Lipids of the Vertebrate Central Nervous System

... Expressed as a percentage of' essential lipid', the concentration of cerebroside, cholesterol, sphingomyelin, sphingolipid and myelin lipid, but not of lecithin and kephalin, was greater[r] ...

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A Comparative Study of the Lipids of the Vertebrate Central Nervous System

A Comparative Study of the Lipids of the Vertebrate Central Nervous System

... The finding that cerebroside, cholesterol and sphingomyelin, and not lecithin and kephalin, occur in a higher concentration in the brains of mammals than in the brains of lower vertebrat[r] ...

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