Leishmania amazonensis
Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice
... Leishmania amazonensis is highly virulent with cap- acity to infect several hosts [7]. BALB/c mice have been used for several studies; however, this model of infection is a progressive non-healing disease. ...
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ANTILEISHMANIAL ACTIVITY OF LEAF EXTRACT FROM CALOPHYLLUM RIVULARE AGAINST LEISHMANIA AMAZONENSIS
... Strain MHOM/77BR/LTB0016 of Leishmania amazonensis was kindly provided by the Department of Immunology, Oswaldo Cruz Foundation (FIOCRUZ), Brazil. Parasites were routinely isolated from mouse lesions and ...
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Leishmania braziliensis and Leishmania amazonensis amastigote extracts differ in their enhancement effect on Leishmania infection when injected intradermally
... of Leishmania amazonensis amastigote extract (LaE) in BALB/c mice exacerbates the infection of these mice by Leishmania ...a Leishmania braziliensis amastigote extract (LbE) would exert the ...
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Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis
... with Leishmania amazonensis, IL-10 partially contributes to the generation of immunodeficient re- sponses [77, 78], which is the main factor by which susceptibility is increased in mice co-infected with ...
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In vitro activity of Morinda citrifolia Linn fruit juice against the axenic amastigote form of Leishmania amazonensis and its hydrogen peroxide induction capacity in BALB/c peritoneal macrophages
... and Leishmania amazonensis [8], however, the activity against axenic amastigote has not yet been ...L. amazonensis correlated macrophage acti- vation and nitric oxide (NO) induction by ...
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Intranasal vaccination with extracellular serine proteases of Leishmania amazonensis confers protective immunity to BALB/c mice against infection
... from Leishmania major culture (SEAgs) have been evaluated as vaccine can- didates against ...from Leishmania amazonensis and we predicted the molecular weight for OPB and OPB2 as ...
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Extracellular matrix alterations in experimental Leishmania amazonensis infection in susceptible and resistant mice
... Leishmania is inoculated, by the bite of an infected sandfly, into the skin of the host, where the promastigotes are phagocyted by dermal macrophages. The dermal region comprises cells and abundant extracellular ...
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Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate
... strain. Leishmania amazonensis is tremen- dously important in public health terms in Brazil and Colombia because of its association with CL and, more recently, VL in both humans and domestic animals (cats ...
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Leishmania amazonensis infection impairs dendritic cell migration from the inflammatory site to the draining lymph node
... of Leishmania infection on the migration of different popula- tions of phagocytes to the draining lymph ...used Leishmania amazonensis ...L. amazonensis strains have also been isolated from ...
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Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole
... Background: Imipramine, a tricyclic antidepressant widely used clinically, has other pharmacological effects, such as antileishmanial activity. Tricyclic antidepressants interact with lipid bilayers, and some studies ...
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Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition
... The first-line drugs for systemic treatment of leish- maniasis are parenterally administered antimonials such as the sodium stibogluconate (Pentostam®) and the N- methyl glucamine antimoniate (Glucantime®) [7, 8] gen- ...
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EVALUATION OF THE IMMUNOMODULATORY EFFECT OF PIPLARTINE AND ITS DERIVATIVE ON PERITONEAL MACROPHAGES OF SWISS MICE INFECTED WITH LEISHMANIA AMAZONENSIS
... ABSTRACT: Piplartine is an amide obtained from Piper tuberculatum, which is promising in antiparasitic tests. Therefore, it has been used as the basis for the synthesis of new molecules. This study was designed to ...
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Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensisto nitric oxide correlates with disease severity in Tegumentary Leishmaniasis
... sistent with the observed high degree of DNA polymor- phism between isolates of L. (V.) braziliensis from several endemic areas of Brazil, documented in literature reports. Techniques used to discern these polymorphic ...
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Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection
... L. amazonensis. It has been reported that L. amazonensis triggers less ROS production by macro- phages from CBA mice in vitro 30 min after infection ...L. amazonensis 30 min and 5 days post-infection ...
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IL 32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
... L. amazonensis induces a strong IL-32 expression in human cutaneous ...L. amazonensis caused skin ...L. amazonensis and lead to improved heal- ing of the ...L. amazonensis strongly modulates ...
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In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis
... uptake of macromolecules by promastigotes occurs through the flagellar pocket, which is an invagination of the plasma membrane, devoid of microtubules. This re- gion is the only place where exocytic and endocytic activ- ...
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Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
... The Brazilian Le. amazonensis reference strain (IFLA/ BR/1967/PH8) was isolated from the sand fly Lu. flavis- cutellata from Pará State, whereas the Josefa strain (MHOM/BR/1975/Josefa) was isolated from a patient ...
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Low-Dose UVB Contributes to Host Resistance against Leishmania amazonensis Infection in Mice through Induction of Gamma Interferon and Tumor Necrosis Factor Alpha Cytokines
... many Leishmania parasites were also seen outside ...few Leishmania parasites phagocytized by dermal macrophages ...mice, Leishmania par- asites were also phagocytized by dermal eosinophils ...
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BIOCHEMICAL PURIFICATION OF PROTEINS FROM BERTHOLLETIA EXCELSA SEEDS AND THEIR ANTILEISHMANIAL ACTION IN VITRO
... Bertholletia excelsa is utilized as a folk medicine by the local population of the Amazon basin to treat several health problems. The aims of the study were to survey new protein extracts from B. excelsa seeds and test ...
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Polymorphism specific PCR enhances the diagnostic performance of American tegumentary leishmaniasis and allows the rapid identification of Leishmania species from Argentina
... that Leishmania (Vian- nia) braziliensis was the prevalent species causing three different clinical forms of ATL: cutaneous (CL), mucocu- taneous (MCL), and recurrent cutaneous leishmaniasis in Salta ...province. ...
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