LEISHMANIA-MAJOR INFECTION
Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection
... The aryl hydrocarbon receptor (AhR) is a ligand-activated receptor that mediates the toxicity of environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recently, it has been shown that the AhR ...
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Effects of glucocorticoids in Leishmania major infection
... the infection itself which down regulates the requisite signaling between macrophage and T ...with infection rates and amastigote growth in the macrophages (Figures 4 and 5), this study suggest that ...
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Role of imiquimod as adjuvant for vaccination against Leishmania major infection in BALB/c mice
... ble. A wide variety of adjuvants to achieve this goal are currently available, but all have limitations. Hy- drous sulfate of aluminum (Alum) has been used as adjuvant for vaccine formulations in human with FDA approval. ...
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Experimental therapeutic studies of Solanum aculeastrum Dunal. on Leishmania major infection in BALB/c mice
... Infections caused by the genus parasites of Leishmania are major worldwide problems with high endemicity in developing countries. Treatment of leishmaniases suffers from problems of misdiagnosis and the ...
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Prevalence and determinants of Leishmania major infection in emerging and old foci in Tunisia
... No significant difference was found between males and females suggesting that they are equally exposed to infection. Likewise, Leishmaniasis risk was not asso- ciated with occupation or outdoor activities. Thus, ...
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Expression of Pro-inflammatory Genes in Lesions and Neutrophils during Leishmania major Infection in BALB/c Mice
... combinant Leishmania major secreting biological- ly active granulocyte-macrophage colony- stimulating factor survives poorly in macro- phages in vitro and delays disease development in ...
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Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection
... L. major infection was also noted in an independent line of mice in which IL-4Ra is efficiently deleted from CD4, CD8, NK–T, and cd T cells (unpublished data), indicating that IL-4–responsive CD4 þ T cells ...
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Experimental therapeutic assays of Tephrosia vogelii against Leishmania major infection in murine model: in vitro and in vivo
... Leishmania major (strain IDUB/KE/83=NLB-144) which was originally isolated in 1983 from a female Phle- botomus dubosqi collected near marigat, Baringo County in Kenya were used ...
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Leishmania major infection in a dog with cutaneous manifestations
... bacterial infection of the ...different Leishmania species and it was also re- ported in cases of canine ...tropica infection [5, 17, 18]. The presence of L. major in regional lymph node, as ...
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IL 32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
... 24. Cangussu SD, Souza CC, Campos CF, Vieira LQ, Afonso LC, Arantes RM. Histopathology of Leishmania major infection: revisiting L. major histopathology in the ear dermis infection ...
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Gene-specific sex effects on eosinophil infiltration in leishmaniasis
... of Leishmania major infection using mouse strains BALB/c, STS, and recombinant congenic strains CcS-1,-3,-4,-5,-7,-9,-11,-12, -15,-16,-18, and -20, each of which contains a different random set of ...
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Absence of tumor necrosis factor supports alternative activation of macrophages in the liver after infection with Leishmania major
... Multicolor flow cytometry was performed following an esta- blished protocol (23). Cells were stained first for surface marker expression with rat antimouse CD45 (Biotinylated; 30-F11; BD Biosciences), rat antimouse Ly6C ...
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Canine leishmaniosis caused by Leishmania major and Leishmania tropica: comparative findings and serology
... /l). Stained blood smear evaluation revealed inclusions in thrombocytes suspected as Anaplasma platys morulae and large form Babesia sp. organisms in erythro- cytes. PCR for Anaplasma sp. and for Babesia sp. was carried ...
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Molecular epidemiological study of cutaneous leishmaniasis in the focus of bushehr city, southwestern iran.
... L. major and ...L. major, ...2010b). Leishmania turanica was also iso- lated from Nesokia indica in an area lies on the border between Iran and Iraq in 2009 (Hajjaran et ...2009). Leishmania ...
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Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
... The high variability in sensitivity to ROS and NO found in this study suggests that field isolates vary in resistance to these antimicrobial molecules. This can have a high im- pact not only in their interaction with the ...
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An integrated pipeline for the development of novel panels of mapped microsatellite markers for Leishmania donovani complex, Leishmania braziliensis and Leishmania major.
... Microsatellite loci - The abundance of different microsatellite repeats, identified by the Perl programme, in the Leishmania species for which sequence data are available is shown in Table 2. Microsatellite repeat ...
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Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum
... Introduction: Leishmaniasis is a severe disease that presents a real public health problem worldwide. Antileishmanial therapy remains expensive with intolerable side effects; therefore, it is essential to develop ...
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<p>Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds</p>
... Leishmaniasis and trypanosomiasis are arthropod-borne diseases of humans and animals caused by infection with protozoan hemo fl agellates of the genus Leishmania and Trypanosoma, respectively. The two genera ...
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Sequence Analysis of HSP70 Gene of Leishmania major and Leishmania tropica in Chabahar and Mashhad
... two Leishmania species, the determination of the specie is necessary to tackle the ...(5). Leishmania needs to adapt to the ambient temperature and body temperature of mammalian hosts during its two-host ...
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Population genetics of Leishmania (Leishmania) major DNA isolated from cutaneous leishmaniasis patients in Pakistan based on multilocus microsatellite typing
... (L.) major DNA samples isolated from Pakistani CL cases during the period of 2003 to 2004 were analyzed in this ...(L.) major based on parasite-specific kineto- plast DNA (kDNA) sequences [15] the DNA was ...
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