Leishmania mexicana
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB
... mature Leishmania mexicana cysteine protease ...L. mexicana cysteine protease CPB that may also have useful efficacy against other important cysteine ...
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The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis
... quantitate Leishmania mexicana development in vivo, with respect to both time and gut ...of Leishmania found in the sandfly and their individual ...L. mexicana has been studied in both natural ...
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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana
... to Leishmania interacting with the cell in a different way to LPS, both agents utilised TLR-4 during the early stages of ...that Leishmania mexicana alone does not induce MKP-2 points to another ...
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Germacranolide type sesquiterpene lactones from Smallanthus sonchifolius with promising activity against Leishmania mexicana and Trypanosoma cruzi
... Literature data indicate that the leaves of this plant have antibacterial, anti-inflammatory and antifungal properties [24 – 26]. We have previously reported the cytotoxicity of six sesquiterpene lactones (STLs) isolated ...
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A Negative Regulatory Element Controls mRNA Abundance of the Leishmania mexicana Paraflagellar Rod Gene PFR2
... The Leishmania mexicana PFR2 locus encodes a component of the paraflagellar rod (PFR), a flagellar structure found only in the insect stage of the life ...L. mexicana PFR genes examined so far, we ...
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The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis
... quantitate Leishmania mexicana development in vivo, with respect to both time and gut ...of Leishmania found in the sandfly and their individual ...L. mexicana has been studied in both natural ...
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Sterol 14α demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
... Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being pro- moted in a campaign to bring the ...
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Glucose Transporters and Virulence in Leishmania mexicana
... ABSTRACT Glucose transporters are important for viability and infectivity of the disease-causing amastigote stages of Leishmania mexicana. The Δgt1-3 null mutant, in which the 3 clustered glucose ...
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Transformation of Leishmania mexicana metacyclic promastigotes to amastigote like forms mediated by binding of human C reactive protein
... of Leishmania mexicana metacyclic promastigotes to amastigote-like forms in response to temperature, pH, whole serum and a specific serum component : the acute phase protein, C-reactive protein ...of ...
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Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8
... Papain-like cysteine proteases have been identified in parasitic organisms, such as T. cruzi (cruzain), T. brucei (trypanopain, TbCatB) and different Leishmania spp. (CPA, CPB, CPC) [1]. The cysteine proteinase ...
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The mRNA-bound proteome of Leishmania mexicana : novel genetic insight into an ancient parasite
... L. mexicana proteomes of each stage (PCF, META, AMA(MØ)) yielded 2403 proteins identified, 1174 of which are significantly enriched at one lifecycle stage ...
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Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation
... B. Experimental crk3::DICRE/CRK3 [SSU GFP Flox ] or control [SSU GFP Flox ] L. mexicana promastigotes were seeded at 1x10 6 cells ml -1 and incubated in the presence or absence of between 1 to 250 nM rapamycin. ...
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A galactosyl(alpha 1 3)mannose epitope on phospholipids of Leishmania mexicana and L braziliensis is recognized by trypanosomatid infected human sera
... Anti-Galal-3Man antibody readily absorbed to American Leishmania and Trypanosoma culture forms, suggesting a surface membrane localization of reactive epitope.. Galal-3Man-bearing glycop[r] ...
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Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding
... Recently emerged 0-3 h females were collected and maintained with water for 3 days before feeding with an infected blood meal.. After feeding, insects were maintained with sucrose 1.2 M [r] ...
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Axenic cultivation and characterization of Leishmania mexicana amastigote like forms
... mexicana axenic amastigotes were similar in infectivity to those isolated directly from infected animals, and both of these were significantly more infective than promastigotes.. In summ[r] ...
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Complete developmental cycle of Leishmania mexicana in axenic culture
... After inoculation of promastigote culture medium with lesion amastigotes various intermediate forms in the process of transformation from amastigotes to promastigotes were observed see H[r] ...
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Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection
... with Leishmania mexicana in a ...of Leishmania promastigotes inside the sand fly gut 72 h after the bloodmeal and the number of sand flies infected were compared to control flies (Figure ...the ...
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Polymorphism specific PCR enhances the diagnostic performance of American tegumentary leishmaniasis and allows the rapid identification of Leishmania species from Argentina
... the Leishmania mexicana or donovani complexes were found involved in cases of leishmaniasis in this area [4,25], we could not prove their involvement in the present series (Table ...
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Comparison of Cysteine Protease B Gene Expression between Clinical Isolates of Leishmania tropica, Leishmania major and Leishmania infantum
... of Leishmania, the number and sequence of the CPB gene are ...In Leishmania mexicana, CPB is located in one locus with 19 copies arranged in a tandem ...the Leishmania donovani complex, there ...
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Diagnosis of cutaneous leishmaniasis and species discrimination of parasites by PCR and hybridization
... By hybridizing the PCR product to new kDNA probes specific for either Leishmania mexicana or Leishmania braziliensis, we found that both species are major causes of cutaneous leishmanias[r] ...
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