Lens fiber cell differentiation
Wnt signaling enhances FGF2 triggered lens fiber cell differentiation
... ocular lens is composed of two distinctive cell types; differentiated fiber cells that make up the bulk of the lens, and a monolayer of epithelial cells that covers the anterior surface of the ...
12
Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis related nuclear disassembly
... terminal differentiation pathway, including removal of nuclei and establishing an OFZ, expands the known functions for this protein beyond those for mitosis and ...the lens, CDK1 deficiency fails to induce ...
11
Pax6 is essential for lens fiber cell differentiation
... of lens development (Ashery-Padan et ...LFC differentiation, we characterized the distribution of crystallin transcripts and proteins in the Pax6-deficient ...
12
The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish
... in lens fiber cell ...wild-type lens sphere (arrowheads, F), whereas nuclei are swollen and located in the anterior region surrounding a small lens fiber core in the vov mutant ...
12
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
... mouse lens fiber cell differentiation. Lens- specific expression of the dnBrg1 perturbed lens fiber cell differentiation process at multiple levels and ...
20
Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation
... in lens development, in particular in regulating lens cell prolifera- tion and lens fiber cell differentiation, for example, through growth factor signaling pathways, ...
12
Caspase dependent secondary lens fiber cell disintegration inα A /αB crystallin double knockout mice
... vertebrate lens offers a unique model system for studying mechanisms of cell ...ocular lens consists of three cell types: epithelial cells, primary lens fiber cells and secondary ...
9
Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation
... primary lens fiber cell ...cKO lens was surrounded by a hypertrophic hyaloid vasculature, leaving a narrower vitreous space between the lens and retina (compare ...cKO lens was ...
11
Profiling of chromatin accessibility and identification of general cis -regulatory mechanisms that control two ocular lens differentiation pathways
... the lens epithelium while its posterior part differ- entiates into the “primary” lens fibers to fill up the space by ...mature lens is formed by highly elongated lens fib- ers that represent ...
23
Frs2α enhances fibroblast growth factor mediated survival and differentiation in lens development
... for fiber differentiation, the specific role of Frs2 in this process remained ...the lens placode, mediated the deletion of a LoxP-flanked Frs2 allele in the presumptive ...the lens increased ...
12
Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression
... (B, cell outlines) and did not upregulate Prox1 ...displayed cell multi-layering and cell elongation (E, cell outlines), features of LF differentiation in vitro, and exhibited elevated ...
11
Lens differentiation and crystallin regulation: a chick model
... the lens to attempt to uncover general mechanisms underlying embryonic induction (Jacobson and Sater, 1988; Gehring and Ikeo, ...of lens tissues, cellular interactions can be easily elucidated in this model ...
13
PKCγ knockout mouse lenses are more susceptible to oxidative stress damage
... from cell to cell (Farahani et ...in lens homeostasis when properly controlled (Gao et ...adjacent cell through open gap junctions could be linked to cell death (Cusato et ...to ...
8
Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation
... of lens cell proliferation and differentiation during ...in lens cells during normal development and whether expression of an activated version of Ras is sufficient to induce either ...
10
Lens stem cells may reside outside the lens capsule: an hypothesis
... of lens stem cells. Analogous to the cornea, we pro- pose that lens stem cells reside in a protected location – the pigmented, vascularized ciliary ...the lens capsule. However, committed lens ...
7
A unique aged human retinal pigmented epithelial cell line useful for studying lens differentiation in vitro
... for lens differentiation. Since pax-6, six-3 and FGFR1 regulate lens crys- tallin expression and fiber differentiation, their expression might explain the “readiness” of the H80HrPE-6 ...
6
Morphological characterization of the AlphaA- and AlphaB-crystallin double knockout mouse lens
... the differentiation of lens epithelial cells [15], however, the significance of alpha-crystallin interaction with actin in differentiation is not ...the lens, alpha-crystal- lin also forms a ...
11
Regulation of cell adhesion and migration in lens development
... ABSTRACT Cell movements during lens development and differentiation involve dynamic regula- tion of cell-matrix and cell-cell ...the lens in light of recent findings about ...
9
Five-year incidence of Nd:YAG laser capsulotomy and association with in vitro proliferation of lens epithelial cells from individual specimens: a case control study
... the lens capsule epithelium specimens, which were approximately 5 mm in diameter, had attached to the bottom of the culture wells and lens cells had started to proliferate and to grow outside the ...
8
Analysis of efficiency and misalignment tolerances in laser diode pigtailing using single ball lens
... mode fiber using single ball lens if the divergence ratio of the elliptical emission of the laser diode is (20/33) the coupling efficiency can reach maximum value around 90% at optimum position of the ball ...
10