let 7b
Over-expression of CDX2 alleviates breast cancer by up-regulating microRNA let-7b and inhibiting COL11A1 expression
... of let-7b in the current ...between let-7b and COL11A1 were predicted by the TargetScanHuman ...and let-7b inhib- ited lymph node metastasis and tumor growth by silenc- ing ...
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Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell
... To detect the mRNA level of cyclin D1, Twist, and pre-let-7b in ursolic acid-treated mesothelioma cells, a quantitative real-time PCR was used. Total RNA from ursolic acid treated mesothelioma was used to ...
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Let-7b expression determines response to chemotherapy through the regulation of Cyclin D1 in Glioblastoma
... study, Let-7b down-regulation is associated with acquired cisplatin resistance in U251R ...cells. Let-7b mimics re-sensitized U251R cells to cisplatin through suppression of cyclin D1 protein ...
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Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans
... Background: Recently, plasma miRNAs have been reported as biomarkers for various diseases. However, the knowledge on the association of plasma miRNAs with ischemic stroke is still lacking. In this study, we investigated ...
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let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3
... of let-7b, which forms a partially double-stranded structure with a longer Cy3 modified se- quence (5′-AAC CAC ACA ACC TAC TAC CTC A-3′- Cy3) and a black hole quencher dye 1 (BHQ1) modified shorter sequence ...
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MicroRNA let-7b inhibits keratinocyte differentiation by targeting IL-6 mediated ERK signaling in psoriasis
... Although let-7b was reported to modu- late inflammatory cytokines such as IL-6 in cholangio- carcinoma by short-term oxidative stress responses [36], the in vivo function of let-7b and the ...
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let 7b and let 7c are determinants of intrinsic chemoresistance in renal cell carcinoma
... of let-7d was significantly reduced in patients with recurrence after ...of let-7g expression renders the cells more sensitive to treatment with either Taxol or vinblastine, by targeting IMP-1, resulting in ...
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LPS preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome shuttled let 7b
... miRNAs [51]. In vivo, vasoactive intestinal peptide, an anti-inflammatory neuropeptide, directly reduced TLR4 activities via the AKT pathway and suppressed pro-inflam- matory cytokine expression by macrophages [52]. How- ...
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miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy
... Total RNA was extracted from tissues and cells using a mirVana™ miRNA Isolation Kit (Ambion, Carlsbad, CA, USA) according to the manufacturer’s protocols. RNA samples OD260/OD280 ratios ranging from 1.9–2.0 were ...
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<p>Long Non-Coding RNA NEAT1 Promoted Hepatocellular Carcinoma Cell Proliferation and Reduced Apoptosis Through the Regulation of Let-7b-IGF-1R Axis</p>
... (HCC). Let-7b is a miRNA with the effect of a tumor suppressor gene, and its expression level in various tumor tissues is lower than that in normal ...
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LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension
... transition; FBS: Fetal bovine serum; HPH: Hypoxic pulmonary hypertension; iCon: Inhibitor control; siCon, siRNA control; IL-1 α : Interleukin-1 alpha; IL- 1 β : Interleukin-1 beta; IL-6: Interleukin-6; iLet-7b: ...
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PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion
... and let-7b downregulation, while ERK1/2 activation restored PBX3 depletion induced LIN28 downregulation and let-7b up- ...and let-7b upregulation induced by ERK1/2 inhibition ...
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let 7b/g silencing activates AKT signaling to promote gastric carcinogenesis
... extracted using TRIzol reagent (Invitrogen, Grand Island, NY). High Capacity cDNA Reverse Transcription Kits (Applied Biosystems, Grand Island, NY) were used for cDNA synthesis. qRT-PCR was used to quantitative dif- ...
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Serum and thyroid tissue level of let 7b and their correlation with TRAb in Graves’ disease
... of let-7b, was validated in this ...assay, let-7b mainly targeted the first binding site (positions 1889–1895 in the 3 ′ UTR of ...that let-7 miRNAs target the 3 ′ UTR of zbtb mRNA to ...
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Original Article MicroRNA expression profile in stage IA lung adenocarcinoma and miR-940 target prediction
... Abstract: Objectives: Non-small cell lung cancer (NSCLC) is the most common histologic type of lung cancer. Recent clinical studies have indicated that TNM staging does not adequately explain a significant stratification ...
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High-Throughput Profiling of Alpha Interferon- and Interleukin-28B-Regulated MicroRNAs and Identification of let-7s with Anti-Hepatitis C Virus Activity by Targeting IGF2BP1
... of let-7b attenuates the antiviral activity of ...whether let-7b participates in the IFN-mediated inhibi- tion of HCV, we transfected a let-7b inhibitor into ...a ...
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miRNA signature of schwannomas: Possible role(s) of “tumor suppressor” miRNAs in benign tumors
... were let-7d (about 22-fold), miR-451 (about 17-fold), and miR-23b (about ...The let-7 family has been the most studied of the potential “tumor suppressor” miRNAs and contains 11 family members ...of ...
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MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA- p21/β-catenin pathway
... As shown in Figure 3B and 3C, non-GSCs glioma cells displayed significantly lower HuR protein levels than GSCs, while let-7b level showed no significant change between GSCs and non-GSCs [r] ...
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Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities
... In particular, Let-7b miRNA have been shown to re- press KRAS expression and inhibit mutant KRAS- dependent cell growth in vitro and tumor growth in vivo in lung and pancreatic cancer ce[r] ...
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Tough decoy targeting of predominant let 7 miRNA species in adult human hematopoietic cells
... individual let-7 miRNA family members in adult peripheral blood cell populations demon- strated that let-7a and let-7b miRNAs are expressed at much higher levels than the other let-7 ...
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