Leukemia inhibitory factor (LIF)
Induction of cytokine expression by leukemia inhibitory factor
... of leukemia inhibitory factor (LIF) on cytokine expression in different cell ...human LIF increases levels of IL-1 beta, IL-6, and IL-8 mRNA in human articular chondrocytes as ...
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Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line Role of STAT pathway
... of leukemia inhibitory factor (LIF) in human fetal and murine ...corticotrophs. LIF and the related cytokine oncostatin M induced basal, and corticotropin-releasing hormone (CRH) ...
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Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity
... neurotrophic factor; CT-1: cardiotrophin-1; DMEM: Dulbecco ’ s modified Eagle ’ s medium; DMSO: dimethyl sulfoxide; EDTA: ethylenediaminetetraacetic acid; EPAC: Exchange Protein Activated by cAMP; ERK: ...
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Inhibitory roles for SHP 1 and SOCS 3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
... Leukemia inhibitory factor (LIF) is a member of the IL-6 cytokine family ...that LIF plays an important role in the pituitary by modulating the hypothalamo-pituitary-adrenal (HPA) axis ...
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Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: a possible diagnostic tool for impaired fertility
... only factor as yet identified to be absolutely required for successful implantation, leukemia inhibitory factor (LIF) and mucin 1 are regarded as two of the most important signaling ...
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<p>Cigarette smoke exposure reduces leukemia inhibitory factor levels during respiratory syncytial viral infection</p>
... driving factor of chronic obstructive pulmonary disease (COPD) exacerbations and thus contribute to disease morbidity and ...that leukemia inhibitory factor (LIF) expression was ...
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Pituitary directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function A model for human pituitary Rathke's cysts
... Leukemia inhibitory factor (LIF) and LIF receptors are ex- pressed in adenohypophyseal cells and LIF regulates pitu- itary hormone transcription and cell replication in ...
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Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome
... of leukemia inhibitory factor (LIF) in the endometrial tissue of 52 IVF patients, and found that LIF staining intensity was strongly correlated with successful pregnancy ...of ...
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Investigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
... cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony s!mula!ng factor (G- CSF), in the regula!on of early ...
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Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
... PBS, LIF, or sLIFR prior to irradiation and thereafter (LIF: 150–200 ng/ 20 μl PBS, twice/week × 4 weeks; sLIFR: 1–2 μg/20 μl PBS, twice/ week × 4 ...the LIF-treated tumors were sig- nificantly ...
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Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
... hypothalamic LIF in OR mice is accompanied by increased diet-induced hypothalamic inflammation Because LIF expression was rapidly induced in the hypothal- amus of OR mice fed a HFD, we hypothesized that it ...
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Human and murine pituitary expression of leukemia inhibitory factor Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion
... Fetal LIF immunoreactivity colocalized with 30% of ACTH- expressing cells, approximately 20% of somatotrophs, and approximately 15% of non- hormone-expressing ...cells. LIF was also strongly expressed in ...
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Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling
... murine leukemia virus reverse transcriptase (Promega), 10 μl of reverse transcription buffer, oligodeox- ythymidylic acid primer, 25 mM deoxynucleoside triphos- phates mix and RNase inhibitor (Promega) in a final ...
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Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
... of LIF decreased 7 of the 43 genes increased by EPO and differentiation, and 9 of the 113 genes increased only by EPO, as summarized in the Venn diagram in ...by LIF (green arrows, ...note, LIF ...
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Analysis of Apoptosis in Cultured Human Vitrified Ovarian Tissue in the Presence of Leukemia Inhibitory Factor
... (11). LIF has a critical role as a survival factor in several cell types during in vitro culture, acting via phospho- inositide 3-kinase pathways (12, ...13). LIF induces the expression of ...
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Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis
... active LIF and synthesized and secreted LIF proteins that migrated in SDS PAGE at approximately 43 ...4.2-kb LIF mRNA. IL-1 beta, LPS, and to a lesser extent tumor necrosis factor-alpha ...
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Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids
... elevated LIF concentrations (> 10 ng/ml) were detected in cerebrospinal fluid from subjects with bacterial meningitis, in effusions associated with pneumonia and peritonitis, and in amniotic fluid from a woman ...
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Leukemia inhibitory factor inhibits HIV 1 replication and is upregulated in placentae from nontransmitting women
... of LIF action on HIV-1 replication, we first determined the effects of LIF on CD4 and the predominant HIV-1 coreceptors CCR5 and ...with LIF for up to 3 ...cytometry. LIF had no effect on ...
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Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF
... growth factor, NT-3, and platelet-derived growth factor-BB, which are sufficient to prevent Schwann cell death in the absence of axons (Jessen and Mirsky, 1999; Meier et ...that LIF, in combination ...
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gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine–neuro endocrine pathways
... IL-6, leukemia inhibitory factor (LIF), IL-11, oncostatin M (OSM), ciliary neu- rotrophic factor (CNTF), and cardiotropin-1 (CT-1), all of which bind specific receptors (their α ...
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