Lewy body (LB)
Interleukin-1 mediates Alzheimer and Lewy body pathologies
... perhaps indicative of inflammation-related synapse loss, and (ii) an increase in α-synuclein, perhaps in an attempt to repair this very event [34]. The effect of IL-1β on α- synuclein in cultures of primary neurons is ...
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TIGAR inclusion pathology is specific for Lewy body diseases
... into Lewy bodies was only seen in brainstem but not cortical Lewy ...most Lewy body protein components are present in both brainstem and cortical Lewy bodies ...cortical Lewy ...
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Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
... and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia ...the Lewy body, the mechanisms by which neurons ...
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Alpha-synuclein biology in Lewy body diseases
... with Lewy body pathology [62], which is now incorporated in the Diagnostic and Statistical Manual criteria as a cli- nical disease entity (neurocognitive disorder with Lewy ...only Lewy ...
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Lewy Body Dementia (Update)
... Lewy body dementia refers to either of two related diagnoses—dementia with Lewy bodies and Parkinson’s disease ...with Lewy bodies, cognitive symptoms develop within a year of parkinsonism—any ...
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Intra neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
... α-synucleinopathies. Lewy body diseases include PD, PAF, and dementia with Lewy bodies ...prevalent Lewy body disease; (b) PAF being a rare disease; (c) orthostatic hypotension (OH) ...
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Characteristics of facial expression recognition ability in patients with Lewy body disease
... with Lewy bodies (DLB) [18], in which de- mentia develops within 1 year after the appearance of Par- ...as Lewy body disease [19] because proteins called alpha-synuclein accumulate and form ...
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Compensatory shifts in visual perception are associated with hallucinations in Lewy body disorders
... of Lewy body and other ...in Lewy body disease, have similar content to spontaneous hallucinations, and respond to cholinesterase inhibitors in the same ...with Lewy body ...
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Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias
... Lewy body dementias (LBDs) are related brain disorders affecting cognition, motor function, mood, behavior, and autonomic ...The Lewy Body Dementia Association (LBDA) and the Lewy ...
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Lewy body dementia: the impact on patients and caregivers
... the Lewy Body Composite Risk score for which a cut- off score of 3 provides a sensitivity of 90% and specificity of 87% to suggest Lewy body pathology as the under- lying cause of dementia ...
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Tyrosine hydroxylase and Lewy body molecules immunoreactivity in the SNC neurons of an AS/AGU mutantrat
... the Lewy body as- sociated proteins ubiquitin and parkin in the nigral cell bodies of the mutant and to compare them with control (unaffected) animals, individual cells of the two ...
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Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders
... all LBD cases. Interestingly, the PD-MCI group had the highest proportion of cases displaying grade 3 hyperinner- vation although we found no statistically significant differ- ences among the different LBD groups, ...
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Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly
... with Lewy bodies (DLB) are routinely present in normal elderly brain donors ...that Lewy body (LB) pathology contributes significantly to dementia ...of LB pathology, is reported to ...
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MRI of the Swallow Tail Sign: A Useful Marker in the Diagnosis of Lewy Body Dementia?
... glucose metabolism in an AD-like pattern, sparing the medial temporal lobes, with additional involvement of the occipital regions.6-9 Dopaminergic transporter imaging with SPECT is anoth[r] ...
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<p>Cognitive Impairment in Parkinson’s Disease: What We Know so Far</p>
... by Lewy bodies (LB) and Lewy neurites are the dominant and primary substrate of ...with Lewy body densities in the frontal, straight, angular, cingulate, and middle temporal ...and ...
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New α- and γ-synuclein immunopathological lesions in human brain
... Another member of the synuclein family - γ-synuclein (γ-syn) is also aggregation-prone protein which forms intracellular inclusions. γ-Syn is a component of atypical inclusion bodies in human NDDs [7-11]. Furthermore, ...
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APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
... White matter hyperintensities (WMH) observed on structural MRI indicate cerebral small vessel disease (SVD) in most cases, 1 are risk factors for cognitive impairment and Alzheimer disea[r] ...
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Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria
... The aim of this retrospective study was to provide an extensive evaluation of the patterns of brain hypometabolism in a large sample of cases diagnosed with probable DLB at follow-up, in[r] ...
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APOE ɛ4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia
... We used the following multiple linear regression model in the SDS sample N=289 to test associations of WMH with executive functions, memory, and language, and an interaction between WMH [r] ...
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Clinical prevalence of Lewy body dementia
... Our study identified clinical prevalence rates of DLB and PDD in a case series considerably lower than that reported by clinical epidemiological cohorts and neuropathological studies.. I[r] ...
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