Lgr5+ cancer stem cells
Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer
... human Lgr5 or CXCR4 promoter, ...the Lgr5 promoter were 1.9 kb (between -1954 from human Lgr5 transcript start and -48 from human Lgr5 transcript start) and the 5′ and 3′ homology regions for ...
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Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy
... Notably, Lgr5 has been demonstrated upregulated in various cancer tissues, such as basal cell carcinomas, he- patocellular carcinomas, colorectal tumors, and ovarian tumors [55, ...general, Lgr5 ...
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Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells
... Notes: (A) The seven transmembrane domains of the GPCRs activate a panel of heterotrimeric G-proteins that differ at the level of their α-subunits. (B) Upon ligand stimulation of the GPCR, the α-subunit separates from ...
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LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's Esophagus?
... of LgR5 in BE and its relation to potentially cancer-initiating cells in early BE, we analyzed proliferation status of LgR5 expressing early Barrett ...of LgR5+ cells were Ki 67+ ...
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Pten loss in Lgr5+ hair follicle stem cells promotes SCC development
... tissue stem cells give rise to cancer ...follicle stem cells (HFSCs) undergo cyclic quiescence and activation and may sever as the origin of cutaneous squamous cell carcinoma ...
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Cancer Stem Cells in the Personalized Therapy of Colorectal Cancer
... CRC cells to various anticancer agents, commonly used as a mainstay in early, as well as in advanced (metastatic) CRC treatment; the differences in expression level of various CRC-SC molecular markers, including ...
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Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: Implications for targeting cancer stem cells
... affect LGR5 expression, we placed CRC cells into glucose-starved ...LS174t-LGR5 cells not only demonstrated reduced expression of LGR5 but also exhibited a 10–20 kDa lower molecular ...
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Original Article Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer
... colorectal cancer depends highly on the understanding of tumor ...all cells in a tumor have the capacity to propagate the ...the cancer stem cell model, which postulates that stem cell ...
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Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival
... (SP) cancer stem-like cells in colo- rectal cancers using immunocytochemistry after selecting the cells that extruded Hoechst ...SP cells were observed at a frequency of 7% in the ...
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Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
... some cells more readily capable of tumor initiation and propagation than others ...affect cancer stemness behavior of tumor ...derived cells with high vs. low Wnt pathway activity revealed that ...
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A Review on the Biology of Cancer Stem Cells
... isolates cells with a high quality and is regarded as a stan- dard method for cell ...isolate cells based on expression of special stem cell markers like ...Washing cells is the third step and ...
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Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury
... of Lgr5 (Figs 4, 5), a marker of the cycling population of the HF stem cells predominantly residing in secondary hair germ and lower bulge, which is capable of generating all HF cell lineages during ...
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Telomeres, stem cells, senescence, and cancer
... To be sure, adult mammals require extensive prolif- eration and tissue replacement to survive. Even in the absence of pathology, the intestinal lining replaces itself entirely on a weekly basis, and the bone marrow ...
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Mechanisms of chemoresistance in cancer stem cells
... SP cells exhibit chemoresistance related to the ABC transporter expressed in these ...normal cells; P-glycoprotein (MDR1) and breast cancer resistance protein (ABCG2) ...protect cells from ...
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Lgr5+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors
... of Lgr5+ stem cells migrated to the interfollicular epidermis after UV-induced ablation of the epidermal basal layer and during chemically driven epidermal hyperplasia, but not during UV-driven ...
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Stem Cells, Cancer, Immunology and Aging
... - banks and credit institutions. You may contact the processing controller and persons in charge in order to exercise your rights as set forth in article 7 of Legislative Decree no. [r] ...
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Multiple myeloma cancer stem cells
... proliferation, stem cell maintenance, and carcinogenesis [73, 75, ...of cancer, including skin, leukemia, lung, brain, and gastrointestinal cancers ...
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Role of cancer stem cells in hepatocarcinogenesis
... prevalent cancer in the world, and the third leading cause of cancer-related death, with an annual death rate exceeding ...late-stage cancer to this and almost all other available chemotherapeutic ...
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Role of cancer stem cells in breast and prostate cancer
... these cells are resistant to apoptosis (Vaux, Cory and Adams 1988, Sentman et ...in cancer as this impairs cellular function to a dormant state rather than killing the cell (Li, Chen and Gibson 2013a, Ito ...
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Ovarian cancer: emerging concept on cancer stem cells
... Cancer stem cells may arise following transforming muta- tions that occur in untransformed stem cells, progenitor cells, mature cells, and cancer ...of ...
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