light-chain 3 protein
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein
... for 3 s before being centrifuged at 13,000 x g for 20 min at 4 ...and protein concentrations determined using a bicinchoninic acid protein concentration assay kit (Pierce) according to the ...
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Microtubule associated protein 1 light chain 3 is a fibronectin mRNA binding protein linked to mRNA translation in lamb vascular smooth muscle cells
... FN 3 9 UTR into primary cultured ...the 3 9 UTR of FN mRNA decreases mRNA stability while enhancing mRNA translation, and are consistent with previous work indicating that degradation of mRNA by GM- CSF and ...
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Original Article High level of microtubule-associated protein light chain 3 predicts poor prognosis in resectable esophageal squamous cell carcinoma
... Abstract: Microtubule-associated protein light chain 3 (LC3) is a key mediator bridging autophagy, apoptosis and differentiation. However, its role and clinical significance in resectable ...
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Interaction of the Rabies Virus P Protein with the LC8 Dynein Light Chain
... The functional significance of the P-LC8 interaction remains a matter for speculation. In addition to interacting with nNOS and dynein, LC8 interacts with myosin V and IB␣, suggesting that it may have multiple ...
5
Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and “aggregoma”: an update on classification and diagnosis
... presented with dyspraxia and fluctuating hypoesthesia of the right hand at the end of 2006; her cranial nerves were not affected. She complained of increased fatigue but did not present with weight loss, night sweats, ...
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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control
... (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol ...(microtubule-associated protein 1 light chain 3), thus leading to an ...
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Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
... temperature, the beads were washed with a magnetic separator, and an initial volume, i.e., 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide 1 bead solution volume in the previous step, of 0.3 mg/mL ice cold ...
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Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
... There is considerable overlap between the different subtypes of FTD, both clinically and neuropathologically. A major challenge in diagnosing FTD is the difficulty in predicting a neuropathological subtype based on ...
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Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3
... For each participant, venous blood was collected in BD Vacutainer tubes (Plymouth PL6 7BP, UK) containing separation gel. Blood samples were rested for 30 min at room temperature and centrifuged at 2000×g for 10 min at 4 ...
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The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion
... two light-intermediate chains, and several light chains ...different light-chain dimers, Tctex-1/Tctex-3, Roadblock- 1/Roadblock-2, and LC8-1/LC8-2 ...dynein light chain ...
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Expression of Autophagy and Reactive Oxygen Species Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma
... [beclin-1, light chain (LC) 3A, LC3B, p62, and BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)] and ROS related proteins [catalase, thioredoxinreductase, glutathione ...
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Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice
... that protein is being incorporated into the myofibril, we were interested in looking at sarcomeric organization more ...(Fig. 3 A ...(Fig. 3 B ...(Fig. 3 B ...(Fig. 3 C ...
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G<sub>2</sub>/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
... X protein (Bax) and p53-upregulated modulator of apoptosis (PUMA), and increased the expression of cleaved caspases 3 and ...microtubule-associated protein 1 light chain 3 ...
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Blood-based NfLA biomarker for differential diagnosis of parkinsonian disorder
... and blood NfL are not increased in PD, which could be due in part to less severe and widespread axonal degeneration in PD compared to APD. Diffusion MRI studies have shown extensive white matter dam- age in PSP, MSA, and ...
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Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine
... unfolded protein response (UPR) ...RNA-activated protein kinase-like ER kinase), ATF6 (activating transcription factor-6) and CHOP (C/EBP homologous protein) are exaggerated, then, the dialogue ...
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Protein Kinase A Regulates beta-2 Integrin Avidity Activation and Subsequent Neutrophil Activation via Modulation of Myosin Light Chain Kinase.
... The recruitment of leukocytes, the primary effector cells of inflammation, from the blood stream is one of the earliest steps in the inflammatory response and has been determined to be one of the initial sites of ...
126
Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide protein conjugates Description of a new lambda light chain associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation The Collaborative Vaccine Study Group
... Haemophilus influenzae b polysaccharide (Hib PS)-protein conjugate vaccines differ chemically and immunologically. To determine whether anti-Hib PS variable region expression might differ according to vaccine ...
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Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency: Clinical Presentation and Follow-Up of 50 Patients
... Nineteen (38%) of the 50 patients were already deceased at the time of the study. Mortality in pa- tients presenting with acute hypoglycemia (15/39, 38%) did not differ significantly from that in patients presenting with ...
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Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests
... immediate identification of monoclonal FLCs is essential to permit prompt initiation of treatment and enable renal recovery (Hutchison, et al 2011a, Hutchison, et al 2011b). sFLC nephelometric and turbidimetric ...
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Development and characterization of polyclonal antibody against human kappa light chain in rabbit
... Human immunoglobulin G (IgG) purification. Blood samples were taken from patients referred to the Imam Reza Hospital (Tabriz, Iran) with their informed consent (No. TBZMED.REC.1394.457). Peripheral blood samples were ...
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