LIM-domain
Pasalic, Zlatana (2008): The four and a half LIM domain protein 2 (FHL2) interacts with CALM and is highly expressed in acute myeloid leukemia (AML) with complex aberrant karyotypes. Dissertation, LMU München: Medizinische Fakultät
... half LIM domain protein ...interaction domain in CALM was mapped to amino acids 294 to 335. This domain is also contained in the CALM/AF10 fusion ...
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Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins
... L2 domain of AGO1 (Figure S7C), and, in a similar manner to AGO2, mutation of the conserved serine in AGO1 (S385) to alanine inhibited colocalization with LIMD1, whereas mutation to glutamic acid rescued this ...
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The conserved LIM domain containing focal adhesion protein ZYX 1 regulates synapse maintenance in Caenorhabditis elegans
... C-terminal LIM domains and modulates cytoskeletal organization via the N-terminal ...N-terminal domain of zyxin. Our results demonstrate that the LIM domain moiety of zyxin functions ...
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The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression
... the LIM-domain only (LMO) protein family that act as mo- lecular adaptors, providing a scaffold for multiprotein complexes of DNA-binding factors and transcriptional regulatory proteins ...
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Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice
... The recent finding demonstrating that FHL2 controls liver homeostasis by co-ordinately regulating cell prolif- eration and cell death in hepatocytes [8] and our find- ings demonstrating that FHL2 might be an essential ...
9
Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
... the LIM domain kinase (LIMK). Al- though knockdown of human LIM domain kinase 1 (LIMK1) with short hairpin RNA (shRNA) inhibits HIV infection, no specific small-molecule inhibitor of LIMK has ...
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LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells
... LIM domain–binding protein 1 (LDB1), a nuclear protein lack- ing DNA-binding capacity and enzymatic activity (12), is also required for the maturation of pancreatic endocrine precursors ...and LIM ...
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The cloning and characterisation of link1: A LIM-domain containing protein kinase
... the LIM-only class of proteins, in particular the nuclear proteins RBTN- 1/Ttg-1 (M cGuire et ...of LIM domain sequences, it is likely that one of the two double zinc-finger domains mediates this ...
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<p>RING Finger Protein 38 Mediates LIM Domain Binding 1 Degradation and Regulates Cell Growth in Colorectal Cancer</p>
... domain at its carboxyl end. 7 Among them, RING zinc fi nger motifs are zinc-binding domains in RNF ubiquitin ligase family proteins, which can promote the transfer of E2-present- ing ubiquitin molecules to target ...
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Insertional oncogenesis in 4 patients after retrovirus mediated gene therapy of SCID X1
... patients were successfully treated, 4 of the 9 developed T cell leukemia 31–68 months after gene therapy. In 2 of these cases, blast cells contained activating vector insertions near the LIM domain–only 2 ...
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Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes
... regulating LIM-domain transcription factors through three different mechanisms: Gbx2 and Lhx2 compete for binding to the Lmo3 promoter and exert opposing effects on its transcription; repressing Lmo3 by ...
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Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
... half LIM domain 1 (FHL1), milk fat globule epidermal growth factor 8 (MFGE8, lactadherin), phosphodiesterase 4D-interacting protein (PDE4DIP), and creatine transporter ...
5
Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes
... the LIM domain region nor the FPPPPP motif interaction can alter VASP-mediated actin bundling alone, while the presence of both interactions in full-length zyxin blocks VASP activity in this process, ...
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β Cells led astray by transcription factors and the company they keep
... and LIM domain–binding protein 1 (LDB1) serve to maintain mature adult b cell identity, revealing clues as to how adult b cells can partially dedifferentiate or become reprogrammed into other islet ...
5
Islet to LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
... of LIM complex are protein-protein interactions between the LIM domain and the nuclear LIM interactor (Ldb/NLI/Clim) (Agulnick et ...binding domain, which leads to the formation of NLI ...
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Early evolution of the LIM homeobox gene family
... one LIM domain (Table 1). Thus, Lhx genes with atypical domain compo- sitions predicted in the genomes of Nematostella, Tri- choplax and Hydra, are found to be expressed in those configurations (no ...
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Dicarbonyl stress and dysfunction of the glyoxalase system in periodontal diseases
... Atlastin-3 Ribosome-binding protein 1 Thyroid hormone receptor-associated protein 3 Isoform 2 of Presequence protease, mitochondrial PDZ and LIM domain protein 1 Isoform 2 of 5'-nucleoti[r] ...
436
Ldb1-Mediated Complexes: A Transcriptional Paradigm That Establishes and Maintains Pancreatic Endocrine Cell indentity
... the LIM-Homeodomain factor (LIM-HD) Islet-1 (Isl-1) share a robust functional relationship in directing differentiation of developmental progenitor ...
168
An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein
... N-terminal LIM domain, which is composed of two sequential zinc-binding modules with a typical LIM motif, followed by tandem 35-residue nebulin-like repeats named R1 and R2, and by a C-terminal SRC ...
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Chip mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM HOM proteins Apterous and Lim1 regulate distal leg development
... the LIM-HOM subfamily are characterised by the presence of two tandem repeated LIM domains in the N-terminal end of the protein followed by a ...Each LIM domain consists of two tandem ...
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