Limbal stem cell
Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency
... Limbal stem cell damage after chemical injury, autoimmune disorders or iatrogenic trauma leads to corneal conjunctivalisation with new vessel formation, epithelium instability and visual ...loss. ...
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<p>Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency</p>
... with those of other studies, treatments, or diseases. The NIKBUT is obtained objectively by the Keratograph and is observer-independent. The data cannot be modi fi ed, and greater accuracy is achieved than with subjective ...
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Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
... cultured limbal epithelial transplantation; BCVA: Best-corrected visual acuity; CFE: Colony-forming efficiency; CLAU: Conjunctival limbal autograft; CLET: Cultivated limbal epithelium ...
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Results of a phase I/II clinical trial: standardized, non xenogenic, cultivated limbal stem cell transplantation
... two limbal explants were obtained from each eye (total n = 10), Limbal stem cell amnion grafts were generated using methods described previously ...
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Limbal stem cell transplantation: current perspectives
... at limbal stem cell transplantation, the ocular surface must be ...ing stem cells to regenerate and the best-possible conditions for the transplanted stem cells to ...
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Management of pediatric corneal limbal dermoids
... pediatric limbal dermoids (ie, with superficial corneal involvment) is initially ...and limbal stem cell tranplantation are ...Keywords: limbal dermoid, amniotic membrane, surgical ...
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Characterisation and evaluation of the impact of microfabricated pockets on the performance of limbal epithelial stem cells in biodegradable PLGA membranes for corneal regeneration
... of limbal stem cell niches in the eye and they can be custom-designed as previously described by our group using a combination of ...both cell suspension (schematic e) and tissue explants ...
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Comparative outcome and recurrence in double pterygium surgery – amniotic membrane graft vs conjunctival autograft
... Only AMT is not effective for persistant corneal disorders,when there is 360 degree limbal stem cell deficiency. This could be treated by transplanting limbal stem cells. Although it ...
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Amniotic membrane extract and eye drops: a review of literature and clinical application
... There are many small studies detailing various uses for AME and AMEED. In one prospective non-comparative interventional case series, 14 eyes of 11 patients with acute or chronic chemical burns received AMEED topically ...
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<p>Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective</p>
... Simple Limbal Epithelial Transplantation (SLET) In 2012, Sangwan et al 77 reported a novel surgical technique for the treatment of limbal stem cell de fi ...Simple limbal epithelial ...
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siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy
... the cell lysates from cultures treated with the K12-Leu132Pro-9 siRNA, when compared with the K12 expression in NSC4 treated cultures ...on limbal stem cell differen- tiation by quantifying ...
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Donor age and long-term culture do not negatively influence the stem potential of limbal fibroblast-like stem cells
... of limbal stem cells, which we referred to as fibroblast-like limbal stem cells (f-LSCs) ...enchymal stem cells. In support of this, f-LSCs expressed stem cell surface ...
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A clinical study on the outcome of tenoplasty in ocular chemical injuries.
... Irrespective of the transplantation technique, reepithelialization is facilitated by amniotic tissue if complete or partial limbal stem-cell function is present. Reepithelialization is improved by ...
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<p>Boston Type 1 Keratoprosthesis: Updated Perspectives</p>
... including limbal stem cell transplantation or mucous membrane grafting highlighting that preparation of the ocular surface in severely compromised eyes is an important step that increases ...
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Characterization and Safety Assessment of Bioengineered Limbal Epithelium
... cultivated limbal epithelium on substrates such as amniotic membrane is an established treatment for severe ocular surface disease with limbal stem cell ...of limbal epithelium on ...
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Amniotic membrane allografts: development and clinical utility in ophthalmology
... Amniotic membrane is the innermost layer of the placenta, which after proper cryo- preservation techniques, is used to treat a wide variety of ophthalmic conditions. By serving as a basement membrane, amniotic membrane ...
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Efficacy of cultivated corneal epithelial stem cells for ocular surface reconstruction
... cultivated limbal epithelial transplantation (CLET) in the clinical success ...conjunctival cell contamination ...near-total limbal stem cell deficiency bilaterally (J), undergoes ...
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Ethical issues in living related corneal tissue transplantation
... corneal limbal stem cell deficiency. This involves limbal cell grafts which are transplanted, either directly or after ex vivo expansion, onto recipient stem ...
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Ocular stem cells: a status update!
... for cell-based therapy include buccal mucosal epithelial cells, hair follicle stem cells, and human embryonic stem cells (ESCs) ...non-limbal cell types, cul- tured oral mucosal cells ...
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microRNAs: important regulators of stem cells
... and stem cells, including the differentiation of cardiomyocytes, vascular smooth muscle cells (SMCs), and endothelial cells ...of stem cells has great therapeutic value in regenerative ...
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