lipid homeostasis
IRE1α RNase–dependent lipid homeostasis promotes survival in Myc transformed cancers
... ER homeostasis in cells with oncogene-driven protein synthesis, ER lipid membrane biogenesis must also be regulated to accommodate elevated protein ...ER homeostasis and viability in cells with ...
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The Liver X Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development
... of lipid and cholesterol metabo- ...in lipid metabolism in zebrafish adult brain and eye as well as in zebrafish ...impaired lipid deposition as deter- mined by oil red O staining particularly in the ...
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MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
... myocyte lipid homeostasis and insulin resistance, the direct target remains ...on lipid metabolism, it is also possible that a lipid signal influences Mon- doA nuclear ...
14
Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation
... i) lipid accumulation causes inflammation or ii) absence of Abcg1 triggers inflammation that subsequently leads to the observed lipidosis [48]; which one of these events predominates is still ...cellular ...
9
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
... macrophage lipid accumula- tion and upregulated PPARγ and ABCG1 ...macrophage lipid homeostasis associated with reduced GM-CSF autoanti- body in the pulmonary ...
7
EMC3 coordinates surfactant protein and lipid homeostasis required for respiration
... of lipid synthesis in the Emc3-deleted ...neutral lipid accumu- lation and a more general disruption of cellular lipid ...AT2 lipid synthesis (Supplemental Table 3), abnormal processing and ...
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Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
... lung lipid homeostasis in alveolar macrophages and epithelial ...ENDS-induced lipid deposition, chronic ENDS vapor exposure downregulated innate immunity against viral pathogens in resident ...in ...
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Regulation of Lipid Homeostasis, Inflammatory Signalling and Atherosclerosis by the Peroxisome Proliferator-Activated Receptor Delta
... Regulation of fat oxidation occurs via multiple mechanisms. CPT1 is regulated at a transcriptional level by a series of complex transcription factors including PPARγ- coactivator 1 α (PGC1α), PPARα and PPARδ. ...
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Involvement of the Saccharomyces cerevisiae Hydrolase Ldh1p in Lipid Homeostasis
... wild-type cells, ⌬ ldh1 mutant cells, and mutant cells expressing plasmids encoding either wild-type Ldh1p or the mutant Ldh1m1p. LDs appeared as a thick layer on top of the gradi- ent, and comparison of the gradients ...
6
Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet
... hepatic lipid metabolism and also investigate whether the suckling period would exert the same ...in lipid homeostasis observed at gestation are also present at the suckling period by ...
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Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS Dependent Virulence Factor Expression in Staphylococcus aureus
... alteration in the membrane biophysical properties may alter the conformation of the SaeS membrane anchor domain. FA may act as a classical ligand for SaeS binding to a site on the transmembrane domain to stabilize its ...
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Role of Pex11p in Lipid Homeostasis in Yarrowia lipolytica
... the lipid body lysis is still not well understood, but it may involve TGL4 and ...of lipid bodies, ulti- mately leading to their ...death. Lipid homeostasis could also perturb sphingolipid ...
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
... to lipid homeostasis that include cholesterol, triacylglycerol and oleate biosynthesis were among the top most significantly deregulated pathways in these KLF6-depleted 786-M1A cells (Figure ...
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Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat—Store ’em Up or Burn ’em Down
... TAG homeostasis by regulating the activity of Acc1 and, thus, FA de novo synthesis and TAG accumulation (Tehlivets et ...and lipid homeostasis (Kaliszewski and Żołądek ...
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Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.
... reverses glucose intolerance and improves lipid homeostasis in HFD-fed obese and insulin 48.. resistant adult mice.[r] ...
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Ire1α Rnase-Dependent Lipid Homeostasis Promotes Survival In Myc-Transformed Cancers
... Myc overexpression drives tumor growth and progression by altering the expression of thousands of target genes that regulate myriad cellular processes (Dang, 2012). Although Myc- transformed tumors are highly dependent ...
107
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity
... hepatic lipid accumulation results from disruption in import, export, or oxidation of lipids as well as changes in de novo lipid ...proper lipid trafficking and storage in both the liver (7–9) and ...
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Aloss of systemic glucose and lipid homeostasis, Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women
... The production of AMP is particularly important be- cause it is a potent allosteric activator of numerous glycolytic enzymes and of AMP-activated protein kinase (AMPK) (26,27). Activated AMPK plays a key role in the ...
6
Intersection of the Multivesicular Body Pathway and Lipid Homeostasis in RNA Replication by a Positive-Strand RNA Virus
... of lipid syn- thesis ...of lipid synthesis/modification genes, but not to the membrane-shaping functions of the MVB ...of lipid synthesis regulator Mga2p ...
10
Influence of Environmental Chemicals on Regulatory Processes that Control Glucose and Lipid Homeostasis.
... PPARs coordinate several biological processes involved in energy metabolism. Several studies have shown that disruption in PPAR signaling can contribute to etiology of metabolic syndrome, a combination of energy-source ...
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