Lipid storage
Neutral lipid storage disease with myopathy in China: a large multicentric cohort study
... In our series, patient 4 exhibited a missense mutation on the patatin domain and a synonymous mutation. However, we still confirmed the case based on the concurrence of skeletal myopathy and cardiomyopathy, typical MRI ...
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Tumor Promoting Functions of Lipid Storage in Clear Cell Renal Cell Carcinoma
... and lipid/protein scavenging by RAS transformed tumors (Commisso et ...dependent lipid storage occurs early in disease progression and functions to buffer tumor cells against cell intrinsic and ...
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Genome-Wide Analysis of Sterol-Lipid Storage and Trafficking in Saccharomyces cerevisiae
... in lipid droplet biogenesis is the synthesis of its bulk neutral lipid components by the acyltrans- ferases ASAT (Are1p and Are2p) and DGAT/PDAT (Dga1p and ...76). Lipid droplet bio- genesis was also ...
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High lipid storage in vacoular forms of subtype 6 blastocystis sp in ostrich
... using the in-vitro cultivation method. Transmission elec- tron microscopy revealed high electron dense material in the central body of the vacoular forms. We provide evi- dence for the first time, the existence of ...
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Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos
... with lipid storage in Caenorhabditis elegans ...yolk-containing lipid droplets (ccz-1) or have larger genuine lipid droplets ...of lipid-containing droplets in ...embryonic lipid ...
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LRRK2 mediated Rab8a phosphorylation promotes lipid storage
... Recently, a subset of Rab GTPases has been identified as key LRRK2 substrates. Through a combination of phos- phoproteomics and molecular genetics approaches, it has been proved that several Rab GTPases especially Rab8 ...
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Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity
... a lipid storage ...cytoplasmic lipid droplets. Lipid droplets can be subsequently mobilized for the production of ...cytoplasmic lipid droplets in enterocytes after interacting with the ...
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Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer
... and lipid storage capacity of adipose tissue by chemotherapy is a compensatory mechanism for decreased HSL expression, or is the consequence of mitochondrial impairment and inhibited mitochondria-linked ...
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Cerebrotendinous xanthomatosis (a rare lipid storage disorder): a case report
... Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid disorder: phenotype Online Mendelian Inheritance in Man (OMIM)#213700, gene OMIM#606530 [1]. It is caused by mutations in gene CYP27A1 ...
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β Sitosterolemia and Xanthomatosis: A NEWLY DESCRIBED LIPID STORAGE DISEASE IN TWO SISTERS
... We now report elevated plant sterol levels in the blood and tissues of two sisters with extensive tendon xanthomas but normal plasma cholesterol levels.. Besides bsitosterolemia and xant[r] ...
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Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver
... The liver plays pleiotropic roles in modulating fatty acid and carbohydrate homeostasis. With abundant energy in- take, ATP is preferentially generated through carbohydrate oxidation and glycogen stores are replenished ...
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The role of the hyaline spheres in sea cucumber metamorphosis: lipid storage via transport cells in the blastocoel
... Energetic lipid stores in ...a lipid that is more polar than TAG, tentatively identified as FFA, although the red staining of LTC with Nile Red could also indicate a hydro- phobic protein or lipoprotein ...
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Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney
... Cholesterol/fat-rich Western diet induces large vacuoles enriched in free cholesterol, fatty acids and phospholipids and a robust MLB biogenesis in S2/S3 proximal tubules. Intratubular MLBs display lysosomal or ...
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Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review
... of lipid and glucose metabolism and therefore its synthetic ligands such as glitazones – the derivatives of thiazolidinediones ...increased lipid storage in adipose tissue, in which it is most highly ...
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NDRG1 regulates neutral lipid metabolism in breast cancer cells
... Since lipid storage has been shown in a number of cell types to occur as a response to metabolic limitations of hypoxia [44] and glucose starvation [32, 53] and since our results showed that NDRG1 limits ...
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Bent spine syndrome as an initial manifestation of late-onset multiple acyl-CoA dehydrogenase deficiency: a case report and literature review
... Case presentation: A 46-year-old man lost the ability to hold his trunk upright, and had difficulty in raising his head, but he had no obvious symptoms of limb weakness. Meanwhile, he developed persistent numbness of ...
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Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD
... by lipid accumulation in hepatocytes [1, 2] that leads to a spectrum of liver dysfunction ranging from excess lipid storage in the liver (hepatosteatosis) to progres- sive non-alcoholic ...
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Lipid recovery from a vegetable oil emulsion using microbial enrichment cultures
... TAG storage only, supporting the indication of growth of microorganisms in both the feast phase and the famine ...of lipid storage on substrate of ...
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A New Patient of Chanarin Dorfman Syndrome in Egypt
... Neutral lipid storage diseases (NLSDs) characterized by an impairment in the triacylglycerol degradation and its abnormal accumulation in cytoplasmic lipid droplets present in most tissues ...
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Rab proteins mediate Golgi transport of caveola internalized glycosphingolipids and correct lipid trafficking in Niemann Pick C cells
... defects in membrane trafficking (reviewed in refs. 18–20). In NP-C disease, high levels of unesterified cho- lesterol and certain SLs accumulate in cells as a result of defects in the NPC1 or NPC2 proteins (21, 22). ...
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