Lipocalin-2
Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome
... LCN2: Lipocalin-2; MMP-9: Matrix metalloproteinases-9; MS: Metabolic syndrome; Neutrophils: Number of neutrophils; NGAL: Neutrophil-gelatinase associated lipocalin; SBP: Systolic blood pressure; Scr: ...
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Study of Lipocalin 2 Associated with Neutrophilic Gelatinases (uNGAL) in the Urine in Children with the Microbial Inflammatory Diseases of Kidneys and Urinary Tract
... is Lipocalin-2, associated with neutrophilic gelatinases (NGAL) or siderocalin, which was first identified as a component of specific neutrophilic ...
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Lipocalin-2: Response to a short-term treadmill protocol in obese and normal-weight men
... Lipocalin-2 (Lcn2) has recently been recognized as an adipocyte-drived acute phase protein that is positively correlated with potential effects in obesity and inflammation (Choi et al., 2009; Choi et al., ...
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Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model
... Research Center (MMRRC stock no. 034836-JAX; former JAX stock no. 006293), and lipocalin 2 knock-out (Lcn2 KO) mice were received from the group of Prof. Dr. T. Mak [39] (both lines are on a C57Bl/6 back- ...
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Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis
... Lipocalin 2 levels were significantly higher p < 0.0001 in patients with confirmed acute bacterial meningitis mean 125 pg/mL, range 106–145 pg/mL than in patients with acute viral mening[r] ...
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Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury
... Figure 2 Lipocalin 2 (LCN2) protein was markedly upregulated in the brain 24 h after intraventricular haemoglobin injection compared with saline ...
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Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury
... of lipocalin-2 represents a better biomarker for AKI and CKD than other forms ...(70). Lipocalin-2 binds to ferric enterobactin by interacting with 3 positively charged residues (R81, K125, ...
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Association of lipocalin 2 level, glycemic status and obesity in type 2 diabetes mellitus
... gelatinase-associated lipocalin (NGAL). It belongs to lipocalin family which functions as transporters for hydrophobic molecules ...defined lipocalin-2 as an adipokine that is secreted mainly ...
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Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
... Macrophages play a key role in responding to pathogens and initiate an inflammatory response to combat microbe multiplication. Deactivation of macrophages facilitates resolution of the inflammatory response. Deactivated ...
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Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
... that lipocalin 2 (Lcn2, also known as neutrophil gelatinase–associated lipocalin [NGAL]), the most highly upregulated gene in the FVB/N strain, was not simply a marker of renal lesions, but an active ...
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Functions and regulation of lipocalin 2 in gut origin sepsis: a narrative review
... Once they arrive at the site of infection from the peripheral blood, neutrophils start to perform their antimicrobial functions (which can be suppressed by E. coli-derived enterobactin [58]), including phagocytosis ...
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Lipocalin 2 promotes lung metastasis of murine breast cancer cells
... of lipocalin 2 expression have been reported in various cancers including ovarian cancer, pancreatic cancer, lung cancer, colon cancer and breast cancer, indicating there is a strong association between ...
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Adipokines levels in HIV infected patients: lipocalin 2 and fatty acid binding protein 4 as possible markers of HIV and antiretroviral therapy related adipose tissue inflammation
... that lipocalin-2 levels increase over time after initiating ART [42], but they did not analyze the effect of different ...plasma lipocalin-2 levels according to different ART-regimens ...
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Lipocalin 2: a potential therapeutic target for breast cancer metastasis
... Abstract: Although systematic therapeutic approaches have reduced cancer-associated mortality, metastatic breast cancer can still evade therapy, particularly triple-negative breast cancer, which remains associated with ...
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The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study
... serum lipocalin-2 levels are elevated in patients with CVD and might represent an independent cardiovascular risk factor ...as lipocalin-2 [44]. The formation of the ...
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Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia
... This diversity of siderophores suggests specialization of func- tion. One potential function is to evade host defenses. Indeed, Ent-dependent iron acquisition is completely disrupted by the host protein lipocalin ...
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Lipocalin-2 (Lcn2) expression is mediated by maternal nutrition during the development of the fetal liver
... Abstract The mechanisms by which maternal protein deficiency programs insulin action in the offspring are poorly understood. The interpretation of transcriptomics is complicated by homeostatic adaptations, for example, ...
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Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration
... Lipocalin-2 (Lcn-2) is an acute-phase protein that has been implicated in diverse physiological processes in mice, including: apoptosis, ion transport, inflammation, cell survival, and tumo- ...
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Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people
... serum lipocalin-2 ...of lipocalin-2 in visceral adipose tissue was found to be cor- related with its circulating levels in animal models ...
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Lipocalin 2 is protective against E. coli pneumonia
... that lipocalin 2 is unable to bind all types of siderophores produced by microorganisms ...of lipocalin 2 is due to iron-depletion through binding of enterobactin, we infected wild-type ...
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