Lipocalin-2 (Lcn2)
Lipocalin-2 (Lcn2) expression is mediated by maternal nutrition during the development of the fetal liver
... Abstract The mechanisms by which maternal protein deficiency programs insulin action in the offspring are poorly understood. The interpretation of transcriptomics is complicated by homeostatic adaptations, for example, ...
7
Functions and regulation of lipocalin 2 in gut origin sepsis: a narrative review
... Once they arrive at the site of infection from the peripheral blood, neutrophils start to perform their antimicrobial functions (which can be suppressed by E. coli-derived enterobactin [58]), including phagocytosis ...
8
Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis
... The lipocalin 2 (LCN2) is a small protein of 22 kDa involved in iron homeostasis that allows an alternative method to transferrin to deliver iron to the cytoplasm ...Associated Lipocalin (NGAL) ...
8
Lipocalin 2: a potential therapeutic target for breast cancer metastasis
... Abstract: Although systematic therapeutic approaches have reduced cancer-associated mortality, metastatic breast cancer can still evade therapy, particularly triple-negative breast cancer, which remains associated with ...
8
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
... Lipocalin 2 (LCN2) (12, 13), also known as neutrophil gelati- nase-associated lipocalin, is a mammalian protein expressed by myeloid and epithelial cells in response to TLR activation during ...
11
Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury
... Figure 2 Lipocalin 2 (LCN2) protein was markedly upregulated in the brain 24 h after intraventricular haemoglobin injection compared with saline ...
7
Association of lipocalin 2 level, glycemic status and obesity in type 2 diabetes mellitus
... gelatinase-associated lipocalin (NGAL). It belongs to lipocalin family which functions as transporters for hydrophobic molecules ...defined lipocalin-2 as an adipokine that is secreted mainly ...
6
Lipocalin 2 promotes lung metastasis of murine breast cancer cells
... of lipocalin 2 could not affect the MAPK ...by lipocalin 2 had no effect on survival of 4T1 ...of lipocalin 2 increased migration and invasion of non-Ras-induced 4T1 cells and ...
9
Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
... that lipocalin 2 (Lcn2, also known as neutrophil gelatinase–associated lipocalin [NGAL]), the most highly upregulated gene in the FVB/N strain, was not simply a marker of renal lesions, but an active ...
13
Up-Regulated Lipocalin-2 in Pulmonary Hypertension Involving in Pulmonary Artery SMC Resistance to Apoptosis
... This study was approved by the ethics commit- tee at Fuwai Hospital and conforms to the principles outlined in the Declaration of Helsinki. Informed consent was obtained from the parents of all of the patients. Patients ...
9
Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model
... Research Center (MMRRC stock no. 034836-JAX; former JAX stock no. 006293), and lipocalin 2 knock-out (Lcn2 KO) mice were received from the group of Prof. Dr. T. Mak [39] (both lines are on a C57Bl/6 back- ...
13
Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome
... LCN2: Lipocalin-2; MMP-9: Matrix metalloproteinases-9; MS: Metabolic syndrome; Neutrophils: Number of neutrophils; NGAL: Neutrophil-gelatinase associated lipocalin; SBP: Systolic blood pressure; Scr: ...
7
Lipocalin-2: Response to a short-term treadmill protocol in obese and normal-weight men
... J. Lipocalin-2: Response to a short-term treadmill protocol in obese and normal-weight ...Background: Lipocalin-2 (Lcn2) a newer adipocyte-secreted acute phase protein was recently reported to ...
9
Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury
... adipose lipocalin-2–mediated renal ...adipose-derived lipocalin-2 by proximal tubules leads to acute cell loss by apoptosis and the subsequent proliferative and inflammatory kidney damages ...
20
Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation
... Lipocalin 2 (LCN2), a member of the lipocalin family, is an acute-phase protein with multiple functions [8]. LCN2 is synthesized and released in CNS after inflammation, infec- tion, or injury [9, ...
15
The Bacteriostatic Protein Lipocalin 2 Is Induced in the Central Nervous System of Mice with West Nile Virus Encephalitis
... Lipocalin 2 (Lcn2) is a bacteriostatic factor produced during the innate immune response to bacterial infection. Whether Lcn2 has a function in viral infection is unknown. We investigated the regulation and ...
11
Lipocalin 2 is protective against E. coli pneumonia
... express lipocalin 2 have previously been demonstrated to be more susceptibility towards intraperitoneal ...that lipocalin 2 also plays a role in protection against ...that lipocalin ...
8
Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia
... This diversity of siderophores suggests specialization of func- tion. One potential function is to evade host defenses. Indeed, Ent-dependent iron acquisition is completely disrupted by the host protein lipocalin ...
8
Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people
... type 2 diabetes [11,13,17]. In this study, we also observed serum Lipocalin-2 elevation in both type 2 diabetes and impaired glucose ...that lipocalin-2 might be involved in the ...
8
The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study
... serum lipocalin-2 levels were marginally higher in women with PCOS compared with controls ...serum lipocalin-2 levels in women with PCOS (Group I) compared with controls (Group II) might be ...
8