lipoprotein lipase (LPL)
A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries
... Lipoprotein lipase (LPL) plays a crucial role in the regulation of lipoprotein metabolism by hydrolysing the core triglycerides of circulating chylomicrons and ...human LPL gene is now ...
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High density lipoprotein2 Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase
... Lipoprotein lipase (LPL) activity in postheparin plasma of 38 normolipidemic volunteers was related to the magnitude of postprandial lipemia after a fat meal, to triglyceride content of high density ...
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Amino acid substitution (Ile194 Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands Support for a multicentric origin
... of lipoprotein lipase (LPL) deficiency have been facilitated by the availability of LPL gene probes and the recent characterization of gene mutations underlying human LPL ...the ...
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Lipoprotein lipase levels in patients with Coronary Artery Disease with Type 2 Diabetes Mellitus
... decreased LPL activity which leads to elevated TG levels and reduced high density lipoprotein cholesterol (HDL-C), both risk factors for the development of coronary artery disease ...the Lipoprotein ...
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Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study
... Lipoprotein lipase (LPL) is a member of the so-called lipase superfamily which includes hepatic lipase, pancre- atic lipase and LPL itself ...muscle, LPL has its ...
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Lipoprotein Lipase and Hydrofluoric Acid Deactivate Both Bacterial Lipoproteins and Lipoteichoic Acids, but Platelet-Activating Factor-Acetylhydrolase Degrades Only Lipoteichoic Acids
... 55). Lipoprotein inactivation is commonly achieved by deacylation with a lipoprotein lipase (LPL) or by oxidation with hydrogen peroxide (H 2 O 2 ) (22, 24, ...
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KINETIC STUDIES ON METABOLISM OF LIPOPROTEIN LIPASE
... Coefficient and exponential constants of lipoprotein lipase LPL activity curve in human subjects, dogs, and rabbits injected with heparin, 0.1 mg per kg of body weight K*.. Mean Acute he[r] ...
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Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia No evidence for a triglyceride rich precursor of lipoprotein(a)
... low-density lipoprotein containing apolipoprotein (apo) B-100 and of the genetically polymorphic ...how lipoprotein(a) is assembled and whether there exists a precursor for ...with lipoprotein ...
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Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities
... the lipoprotein lipase (LPL) gene (8 heterozygous and 8 normal subjects), carrier status for the mutation as determined by DNA analysis was related to LPL activity in postheparin plasma, to ...
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Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non insulin dependent diabetes
... the lipoprotein lipase (LPL) gene: a missense mutation, 75Arg-->Ser, inherited through the paternal line and a truncation, 73Tyr- ->Ter, through the maternal ...R75S LPL suggested ...
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Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue
... tissue lipoprotein lipase (LPL) catalytic activity in obese subjects, and in response to a ...activity, LPL activity, immunoreactive mass, and mRNA level were measured in lean and obese ...
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Lipoprotein lipase regulates Fc receptor mediated phagocytosis by macrophages maintained in glucose deficient medium
... Fatty acids are another source of fuel (4, 6), but are the least readily available of the circulating energy sources. Most of the fatty acids in blood or other extracellular fluids are con- tained within lipoproteins ...
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Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes
... To study the regulation of adipose tissue lipoprotein lipase (LPL) in human adipocytes, omental adipose tissue was obtained from healthy subjects and digested in collagenase. The isolated adipocytes ...
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Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte derived macrophages
... of lipoprotein lipase (LPL) mRNA were ...regulate LPL expression, human mono- cyte–derived macrophages were incubated with different ...of LPL mRNA, analyzed by quantitative ...
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Lipoprotein metabolism during acute inhibition of lipoprotein lipase in the cynomolgus monkey
... of lipoprotein lipase (LPL) in the catabolism of nascent and circulating very low density lipoproteins (VLDL) and in the conversion of VLDL to low density lipoproteins (LDL), studies were performed ...
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Molecular studies on primary lipoprotein lipase (LPL) deficiency One base deletion (G916) in exon 5 of LPL gene causes no detectable LPL protein due to the absence of LPL mRNA transcript
... primary lipoprotein lipase (LPL) deficiency in a proband TN and his affected brother SN, both manifesting familial ...Neither LPL activity nor immunoreactive LPL mass was detected in ...
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Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency
... the lipoprotein lipase (LPL) gene from five unrelated Japanese patients with familial LPL ...plasma LPL mass was either virtually absent (patients 1 and 2) or significantly decreased ...
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Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
... Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and liberates free fatty acids that can be used as energy by cardiac ...Although lipoprotein lipase is ...
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Lipoprotein lipase secretion by human monocyte derived macrophages
... much lipase activity, 1 d in culture was sufficient to trigger measureable enzyme ...The lipase activity was stimulated by serum and was inhibited by preincubation with antiserum to bovine ...
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Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones sensitive lipase in human subcutaneous abdominal adipocytes
... In summary, in subcutaneous abdominal adipocytes isolated from women, the progestogens increased LPL protein expression and reduced HSL protein expression relative to control. Similar effects were observed with ...
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