Lipoprotein receptor
Species-Specific Receptor Recognition by a Minor-Group Human Rhinovirus (HRV): HRV Serotype 1A Distinguishes between the Murine and the Human Low-Density Lipoprotein Receptor
... minor receptor group use several members of the low-density lipoprotein receptor superfamily for cell ...low-density lipoprotein receptor but recognizes the murine protein, whereas HRV2 ...
9
Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
... for receptor-mediated lipoprotein ...of lipoprotein removal, in which apo E–containing remnants bind either the low den- sity lipoprotein receptor (LDLR) or the LDLR-related pro- tein ...
12
Roles of low-density lipoprotein receptor-related protein 1 in tumors
... Low-density lipoprotein receptor-related protein 1 (LRP1, also known as CD91), a multifunctional endocytic and cell signaling receptor, is widely expressed on the surface of multiple cell types such ...
8
Expression of alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein and scavenger receptor in human atherosclerotic lesions
... Scavenger receptor mRNA and protein were expressed in lesion macrophages but no expression was found in lesion ...LDL receptor was absent from the lesion area but was expressed in some aortas in medial SMC ...
9
The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans
... density lipoproteins (LDL). The role of the LDL receptor in the catabolism of Lp(a) has been controversial. We therefore investigated the in vivo catabolism of Lp(a) and LDL in five unrelated patients with ...
7
Genetics of the low density lipoprotein receptor Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia
... lymphocytes that had been incubated for 3 days in the absence of lipoproteins so as to induce a high level of LDL receptor activity. Phase-contrast autoradiograms of cells incubated with 125I-LDL and electron ...
20
Regulation of macrophage alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein by lipopolysaccharide and interferon gamma
... and receptor-function levels. In receptor-function studies, the decrease in alpha 2M-R/LRP expression was detected as a 90% decrease in the Bmax or maximum receptor binding capacity for activated ...
7
Autoantibodies to the low density lipoprotein receptor in a subject affected by severe hypercholesterolemia
... that lipoprotein- deficient serum (LPDS) from the patient inhibited the binding of low density lipoprotein (LDL) to human skin fibroblasts cultured in vitro (up to 70%) whereas LPDS from controls had no ...
8
Relationship between apolipoprotein(a) phenotype, lipoprotein(a) concentration in plasma, and low density lipoprotein receptor function in a large kindred with familial hypercholesterolemia due to the pro664 leu mutation in the LDL receptor gene
... density lipoprotein cholesterol, but were remarkably free from premature coronary ...and lipoprotein(a) (Lp(a)) concentration in plasma revealed that in many instances, involving individuals with various ...
11
Common low density lipoprotein receptor mutations in the French Canadian population
... LDL receptor locus, the so-called French Canadian deletion, makes up 60% of the mutant genes responsible for FH in the French Canadian ...LDL receptor mutations in this ...LDL receptor protein that ...
11
The Microbiota Promotes Arterial Thrombosis in Low Density Lipoprotein Receptor Deficient Mice
... protein receptor-deficient (Ldlr ⫺/⫺ ) mice as germfree (GF) and kept these mice for 16 weeks on an atherogenic high-fat Western diet (HFD) under GF isolator condi- tions and under conventionally raised ...
16
Finnish type of low density lipoprotein receptor gene mutation (FH Helsinki) deletes exons encoding the carboxy terminal part of the receptor and creates an internalization defective phenotype
... LDL receptor has been found in many Finnish patients with familial hypercholesterolemia ...mutant receptor differs radically from the normal one because of loss of the domains encoded by exons 16, 17, and ...
8
Association of genetic variations in the 3'UTR of the human low density lipoprotein receptor with the lipid parameters in the Atherosclerosis Risk in Communities (ARIC) Study
... poor receptor binding however, individuals with apoE2 have a reduced level of cholesterol and a reduced risk of atherosclerosis, except for 5%–10 % of apoE2 homozygotes who have a very high level of plasma ...
155
The Regulation of Proprotein Convertase Subtilisin/ Kexin Type 9 and Its Liver Involvement
... The discovery of direct acting antivirals (DAA) against hepatitis C constitutes a turning point in hepatology. Their ability to cure 90% of patients is undoubtedly a success. But worrisome information concerning the high ...
12
The genetic basis of familial hypercholesterolemia: inheritance, linkage, and mutations
... Notes: Low-density lipoprotein receptor gene (LDLR) 5′ promoter region of 300 bp is represented, numbered the A of the ATG codon as +1. The major regulatory regions are indicated with different colors: FP2 ...
12
Ezetimibe Repurposing: An In-Silico Testing of its Potential Anti-giardia Activity
... Giardia leads to human parasitic disease, and it is highly prevalent in the developing countries. The current medication used to treat giardia is associated with numerous side effects. Moreover, the problem of the ...
8
Diversity in expression of heterozygous familial hypercholesterolemia Characterization of a unique kindred
... density lipoprotein receptor (HMWR) are ...density lipoprotein (LDL) level is 360 mg/dl and tendon xanthomata and early coronary disease are ...LDL receptor activity is higher than ...
7
LAB RESEARCH Recombinant Domain V of beta (2)-Glycoprotein I Inhibits OxLDL-induced TF Expression in Macrophages
... density lipoprotein at 5-10 g/mL increased tissue factor and lectin-like oxidised low density lipoprotein receptor expression, whereas 20-50 g/mL oxidised low density lipoprotein attenuated ...
6
Simple micromethods for determination of isoforms of apolipoproteins.
... lipoprotein receptor. This low binding of apo £3,2 to hepatic receptor, is responsible for the retarded clearance of lipoproteins containing apo Ej from plasma in normal individuals and in those with ...
192
Pre beta very low density lipoproteins as precursors of beta very low density lipoproteins A model for the pathogenesis of familial dysbetalipoproteinemia (type III hyperlipoproteinemia)
... hyperlipidemic E3/3 subjects, respectively, had 90 and 280 times the affinity for the apo- B,E(LDL) receptor than did the pre-beta-VLDL from dys-beta subjects. Heparin-induced beta-VLDL from type V hyperlipidemic ...
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