lipoxin A
Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines
... of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after ...the lipoxin receptor (ALX)-like ...
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Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers
... of lipoxin A4 (LXA4), an eicosanoid with counterregulatory inflammatory roles, on PMN migration across cultured monolayers of the human intestinal epithelial cell line ...
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PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo
... Brain-derived neurotrophic factor (BDNF) produced by several tissues in the body including brain, intestines, pancreas and adrenal gland behaves as a transmitter between immune and nervous systems and modulates ...
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Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis
... Results: Here we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat. Expression of Lipoxin A4 (LXA4) was measured in different brain regions after oral administration ...
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Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
... Lipoxin A4 (LXA4) is an eicosanoid generated from ara- chidonic acid via sequential actions of lipoxygenases that appears to act at both temporal and spatially distinct sites from other eicosanoids produced during ...
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Original Article Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells
... that lipoxin A4 was associated with cardiovascular protective effects, including inhibiting inflammatory res- ponses in macrophages and confering a pro- tective phenotypic switch in VSMCs [20, ...
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Original Article Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide-induced acute lung injury by inhibiting activation of mitogen-activated protein kinases and NF-κB in mice
... of lipoxin A4 associated with exacerbated chronic obstructive pulmonary disease (COPD), severe asthma and exercise- induced bronchoconstriction in children asth- ma [15, ...
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The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening
... exogenous Lipoxin A 4 (LXA 4 ) on polymethylmethacrylate (PMMA) induced inflammation, pro- inflammatory cytokines including TNF-α, IL-1β, PGE 2 and GM-CSF were measured by ELISA kits and bone resorption was ...
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Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection
... the lipoxin A4 receptor plays a role in ...the lipoxin A4 receptor-blocked neutrophils showed intact and smaller nuclear morphology without MPO ...the lipoxin A4 receptor as a trigger for the release ...
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Pathogen induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs
... of lipoxin behavior appears to be emerging as antiinflammatory, particularly in respect to neutrophil ...One lipoxin in particular, LXA 4 , has an ...
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Aspirin-triggered lipoxin A4attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells
... Taken together, our current data prove that ATL inhibits the inflammatory activation of BV-2 microglia cells with respect to NO production and pro- inflammatory cytokine expression.. ATL[r] ...
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Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
... 15-LOX: 15-lipoxygenase; CSCs: Cancer stem cells; CXCR4: CXC receptor 4; DMEM: Dulbecco ’ s Modified Eagle ’ s Medium; EMT: Epithelial-mesenchymal transition; FBS: Fetal bovine serum; FP[r] ...
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Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A4 contents in colon, but does not affect severity or prostaglandin E2 content in murine colitis model
... In the present study, dietary ARA supplementation significantly increased ARA content in the colon in a dose-dependent manner, but did not affect colonic in- flammation in a DSS-induced [r] ...
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Neutrophil mediated changes in vascular permeability are inhibited by topical application of aspirin triggered 15 epi lipoxin A4 and novel lipoxin B4 stable analogues
... of lipoxin (LX) in PMN-mediated tissue injury, we prepared several novel LX stable analogues, including analogues of LXA4 and aspirin-triggered 15-epi-LXA4 as well as LXB4, and examined their impact in PMN ...
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Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis
... with lipoxin and ...of lipoxin treatment on various cellular signaling mol- ecules known to influence KSHV ...upon lipoxin and epilipoxin ...with lipoxin and epilipoxin decreased the levels of ...
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Roles of Dendritic Cells in Immunity to Toxoplasma gondii
... Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. Lipoxin A4: a new class of ligand for t[r] ...
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An oily, sustained counter regulatory response to TB
... deficient lipoxin production in the pathogenesis of diverse inflammatory diseases, along with numerous reports of the beneficial effects of lipoxin analog administration in animal models of inflammatory ...
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Host control of Mycobacterium tuberculosis is regulated by 5 lipoxygenase–dependent lipoxin production
... Th1 type cytokine responses are critical in the control of Mycobacterium tuberculosis infection. Recent findings indicate that 5-lipoxygenase–dependent (5-LO–dependent) lipoxins regulate host IL-12 production in vivo. ...
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Leukotriene biosynthetic enzymes as therapeutic targets
... into lipoxin A 4 (LXA 4 ) and also appears to be involved in the bio- synthesis of pro-resolving molecules originating from eicosapen- taenoic and docosahexaenoic acids (Figure 3 and ...study, lipoxin and ...
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Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms
... 52]. Lipoxin A4 (LXA4) derived from Coriolus is an endogenous eicosanoid cap- able to resolving inflammation process, acting as an endogenous “braking signal” in the inflammatory cas- ...aspirin-triggered ...
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