Lipoxin A4
Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling
... whether lipoxin A4 confers any preventative benefits in LPS-induced ALI, we focused on AMs, isolated these cells from rats, pre-treated them with BML-111 for 6 h, and then chal- lenged them with ...the ...
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Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers
... of lipoxin A4 (LXA4), an eicosanoid with counterregulatory inflammatory roles, on PMN migration across cultured monolayers of the human intestinal epithelial cell line ...
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Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis
... Results: Here we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat. Expression of Lipoxin A4 (LXA4) was measured in different brain regions after oral ...
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Original Article Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells
... Lipoxins are generated in humans from arachi- donic acid via LOX enzymes and comprise two distinct regioisomers, lipoxin A4 (LXA4) and LXB4 [16]. Lipoxins are the first class of lipid mediators and function ...
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Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition
... [14]. Lipoxin A4 (LXA4) was shown to inhibit neutrophil and eosinophil recruitment [15], promote macrophage clearance of apoptotic neutro- phils [16], and increase survival in a rat CLP model ...
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Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
... Lipoxin A4 (LXA4) is an eicosanoid generated from ara- chidonic acid via sequential actions of lipoxygenases that appears to act at both temporal and spatially distinct sites from other eicosanoids produced ...
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PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo
... Brain-derived neurotrophic factor (BDNF) produced by several tissues in the body including brain, intestines, pancreas and adrenal gland behaves as a transmitter between immune and nervous systems and modulates ...
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Original Article Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide-induced acute lung injury by inhibiting activation of mitogen-activated protein kinases and NF-κB in mice
... of lipoxin A4 associated with exacerbated chronic obstructive pulmonary disease (COPD), severe asthma and exercise- induced bronchoconstriction in children asth- ma [15, ...
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Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection
... the lipoxin A4 receptor plays a role in ...the lipoxin A4 receptor-blocked neutrophils showed intact and smaller nuclear morphology without MPO ...the lipoxin A4 receptor as a ...
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Pathogen induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs
... of lipoxin behavior appears to be emerging as antiinflammatory, particularly in respect to neutrophil ...One lipoxin in particular, LXA 4 , has an ...
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The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening
... exogenous Lipoxin A 4 (LXA 4 ) on polymethylmethacrylate (PMMA) induced inflammation, pro- inflammatory cytokines including TNF-α, IL-1β, PGE 2 and GM-CSF were measured by ELISA kits and bone resorption was ...
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Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A4 contents in colon, but does not affect severity or prostaglandin E2 content in murine colitis model
... In the present study, dietary ARA supplementation significantly increased ARA content in the colon in a dose-dependent manner, but did not affect colonic in- flammation in a DSS-induced [r] ...
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Corticosteroid suppression of lipoxin A4 and leukotriene B4from alveolar macrophages in severe asthma
... acid metabolism, yet LXs are generated via interactions between 5- and 15-lipoxygenases or 5- and 12-lipoxyge- nases to form structurally distinct compounds that pro- mote the resolution of inflammation. Thus, LXs are ...
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Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
... 15-LOX: 15-lipoxygenase; CSCs: Cancer stem cells; CXCR4: CXC receptor 4; DMEM: Dulbecco ’ s Modified Eagle ’ s Medium; EMT: Epithelial-mesenchymal transition; FBS: Fetal bovine serum; FP[r] ...
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Neutrophil mediated changes in vascular permeability are inhibited by topical application of aspirin triggered 15 epi lipoxin A4 and novel lipoxin B4 stable analogues
... of lipoxin (LX) in PMN-mediated tissue injury, we prepared several novel LX stable analogues, including analogues of LXA4 and aspirin-triggered 15-epi-LXA4 as well as LXB4, and examined their impact in PMN ...
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Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines
... of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after ...the lipoxin receptor ...
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Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms
... 52]. Lipoxin A4 (LXA4) derived from Coriolus is an endogenous eicosanoid cap- able to resolving inflammation process, acting as an endogenous “braking signal” in the inflammatory cas- ...aspirin-triggered ...
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Lipoxin formation during human neutrophil platelet interactions Evidence for the transformation of leukotriene A4 by platelet 12 lipoxygenase in vitro
... both lipoxin A4 and lipoxin B4, which were monitored by reversed-phase high pressure liquid ...leukotriene A4 (LTA4), a candidate for the transmitting signal, was added to platelets, lipoxins ...
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Roles of Dendritic Cells in Immunity to Toxoplasma gondii
... Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. Lipoxin A4: a new class of ligand for t[r] ...
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An oily, sustained counter regulatory response to TB
... important, lipoxin-mediated counter-regulation in experimental TB infection and provide what is believed to be only the second example of host gene ablation leading to better control of exper- imental infection ...
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