lipoxygenase a
In vitro Evaluation of Antiproliferative, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Artemisia nilagirica (C.B.Clarke) Pamp. Leaf Extracts
... In vitro Evaluation of Antiproliferative, Lipoxygenase and Xanthine Oxidase Inhibitory Activities of Artemisia nilagirica (C.B.Clarke) Pamp.. GHAZI*.[r] ...
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Lipoxygenase activity in ontogenesis of ferns Salvinia natans and Polystichum aculeatum
... To isolate LOX preparations, plant samples were homogenized in cooled to 4 °С 0.1 M phos- phate buffer (pH 6.3), which contained 2 mM phenyl- methylsulfonyl fluoride, 0.04% sodium metabisulfite. Homogenate was ...
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Regulation of microsomal prostaglandin E2synthase 1 and 5 lipoxygenase activating protein/5 lipoxygenase by 4 hydroxynonenal in human osteoarthritic chondrocytes
... To more accurately identify whether HNE induced 5LOX at the transcription level, the 5-LOX promoter construct with luciferase gene reporter was transiently transfected into human OA chon[r] ...
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The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5 lipoxygenase activating protein
... Real-time RT-PCR analysis of 5-LO and FLAP mRNA isolated from nor- mal and osteoarthritis osteoblasts. Confluent cells were incubated for their last 48 hours in Ham's F12/DMEM medium containing 0.5% BSA. Cells were lyzed ...
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Expression of 5 lipoxygenase and 15 lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
... 15-Lipoxygenase (15-LO) is a lipid-peroxidizing enzyme mainly expressed in airway epithelial cells, eosinophils, reticulocytes and macrophages. In humans, 15-LO exists as two different enzymes with different cell ...
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In-Vitro Anti-inflammatory Activity Evaluation of the Latex Protease of Holostemma Ada-Kodien Schult
... The anti-inflammatory effects of H. ada-kodien latex protease (HA protease) on the production of leukotrienes were estimated by inhibition of lipoxygenase activity. Results are shown in the Table.2. The HA ...
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Arachidonic Acid Metabolism in the Neonatal Platelet
... Evaluation of the products of the lipoxygenase and cyclooxygenase pathway in the platelet of the neonate revealed an increase in the production of the lipoxygenase product HETE, whereas [r] ...
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PHYTOCHEMICAL ANALYSIS AND ANTI-INFLAMMATORY ACTIVITY OF MEDICINAL PLANT AQUEOUS AND ETHANOLIC EXTRACT OF BOERHAAVIA DIFFUSA LEAVES EXTRACTS
... Anti-Lipoxygenase activity of aqueous and ethanol extract was studied according the method of Shinde et al. [17] In this assay, linoleicacid was used as substrate which initiates the reaction and lipoxidase as ...
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In vivo action of 15 lipoxygenase in early stages of human atherogenesis
... rotic lesions (4). Although the mechanism of foam cell forma- tion in vivo is unclear it has been suggested that foam cells develop from peripheral monocytes/macrophages or from smooth muscle cells by taking up modified ...
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Antioxidant and Lipoxygenase Inhibitory Activity of the Kino of Eucalyptus citriodora
... 15-Lipoxygenase assays of ethanol extract and its three fractions of E. citriodora kino were shown in a dose- dependent manner and expressed as IC 50 values. The ethanol extract, EtOAc, n-BuOH and aqueous ...
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The impairment of endothelium-dependent relaxations in isolated rabbit aorta and coronary arteries by low-density lipoproteins and oxidised fatty acids
... 15- lipoxygenase activity in vascular tissues as a protective response to hypercholesterolaemia (Simon et al, ...abundant lipoxygenase-derived product formed in aortae from atherosclerotic rabbits with more ...
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Purification and properties of lipoxygenase from wheat seedlings infected by Fusarium graminearum and treated by salicylic acid
... of lipoxygenase was performed with the help of the equipment of the firm LKB (Sweden), using a lowtemperature cabinet (Combicoldrac II), peristaltic pump (Microperpex), ultraviolet detec tor with a flowtype ...
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Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques
... 15- lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic ...omega-6 ...
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Journal of Applied Pharmaceutical Science
... genital apparatus inflammation, in the treatment of malaria (Nacoulma, 1996). Despite the widespread use of species belonging to the amaranthaceae’s family, scientific literature provide little data on the biological ...
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Design of ionic liquid-based microwave-assisted extraction of flavonoids from Cyclea barbata Miers. and its lipoxygenase inhibitory activity
... The LIA assay was conducted using baicalein as a standard (Putri et al., 2017). Baicalein is a flavonoid from flavonols groups (Kusmardiyani et al., 2014) that has the capability to inhibit the lipoxygenase ...
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Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population
... 5- lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American ...
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Systems pharmacology based approach to investigate the in vivo therapeutic efficacy of Albizia lebbeck (L ) in experimental model of Parkinson’s disease
... 12- lipoxygenase, 12S-type; ALOX12B: Arachidonate 12-lipoxygenase, 12R-type; ALOX15: Arachidonate 15-lipoxygenase; ALOX15B: Arachidonate 15- lipoxygenase B; ALOX5: Arachidonate ...
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Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice
... The chromosome 6 locus contains more than one gene affecting atherosclerosis: To investigate if the genetic effect of the CON6 locus on atherosclerosis is due to one or multiple genes, w[r] ...
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Human articular chondrocytes express 15 lipoxygenase 1 and 2: potential role in osteoarthritis
... The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes, and to investigate the effects of their metabolites 13S-hydroxy oc[r] ...
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Bile salt stimulation of colonic epithelial proliferation Evidence for involvement of lipoxygenase products
... Specifically, the relationships between bile salt-induced increases in colonic mucosal ornithine decarboxylase ODC activity and DNA synthesis and an increased generation of lipoxygenase [r] ...
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