Liver sinusoidal endothelial cells (LSEC)
Antagonism of RNase L Is Required for Murine Coronavirus Replication in Kupffer Cells and Liver Sinusoidal Endothelial Cells but Not in Hepatocytes
... the liver sinusoidal endothelial cells (LSEC) was adapted from previously described methods ...the liver was digested with colla- genase I ...the liver was removed and ...
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Liver Sinusoidal Endothelial Cells Are a Site of Murine Cytomegalovirus Latency and Reactivation
... following liver transplantation. Although hematopoietic cells of the myeloid lineage are a recognized source of latent CMV, the cellular sites of latency in the liver are not comprehensively ...
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Liver sinusoidal endothelial cells and liver regeneration
... that liver sinusoidal endothelial cells (LSECs) contribute to liver regenera- tion, demonstrating that hepatic stellate cells serve as the major source of HGF in normal ...
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Original Article SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells
... SK-Hep1 cells, indicating high and rapid endocytic ...SK-Hep1 cells and was consistent with a virally transformed immortal LSEC line ...SK-Hep1 cells are able to take up FITC-FSA [10], no ...
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A new reporter mouse cytomegalovirus reveals maintained immediate early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells
... an LSEC cell line that enabled us to study cell cycle dependent infection, showing that cell cycling does not affect MIEP gene expression, although it severely limits virus ...an LSEC line because ...
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Nanocapsule delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice
... Endothelial cells have been used as a target for FVIII gene replace- ment in both ex vivo (59, 60) and in vivo (40) ...transplanted endothelial cells using an ex vivo strategy depended on the ...
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Mouse Hepatitis Virus Infection Induces a Toll-Like Receptor 2-Dependent Activation of Inflammatory Functions in Liver Sinusoidal Endothelial Cells during Acute Hepatitis
... TLR2 activation by virulent MHV3 decreases IL-10 and in- creases inflammatory cytokine and chemokine expression. It was previously reported that hepatic levels of IL-6 and TNF-␣ were reduced in MHV3-infected TLR2 KO mice ...
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Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids
... Isolation and characterization of SEC. To examine eNOS reg- ulation in SEC, it was necessary to isolate and culture a pure population of SEC. Collagenase-digested livers which were subjected to a series of filtering ...
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Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
... the liver to regenerate is crucial to protect liver function after injury and during chronic ...in liver sinusoidal endothelial cells (LSECs) are thought to drive liver ...
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Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice
... healthy cells to repair organ damage or replace deficient functions constitutes a major goal of cell ...transplanted cells engraft, proliferate, and function remain ...host liver sinusoidal ...
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Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response
... primary cells in vitro ...severe liver graft inflammatory response, especially in living donor liver ...rat liver transplantation ...primary cells, the knockout of Rap1 suppressed ...
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Arsenic stimulated liver sinusoidal capillarization in mice requires NADPH oxidase–generated superoxide
... with liver portal hypertension, vascular shunting, and portal fibrosis through unknown ...in liver sinusoidal endothelial cells (SECs), including SEC defenestration, capillarization, ...
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Advances in sepsis-associated liver dysfunction
... revealed liver dysfunction as an early event in sepsis. Sepsis-associated liver dysfunction is mainly resulted from systemic or microcirculatory disturbances, spillovers of bacteria and endotoxin ...
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MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis
... CRC cells was dramatically ...cancer cells by a soluble factor derived from fibroblasts which conditioned media from the mouse L fibroblast cell line induced protrusive structures and motility of human ...
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Cell specific expression of hepatocyte growth factor in liver Upregulation in sinusoidal endothelial cells after carbon tetrachloride
... in liver regeneration, was examined in normal liver and in hepatic regeneration induced by carbon ...normal liver, HGF and its mRNA were abundant in lipocytes, with smaller amounts present also in ...
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The role of the liver in the migration of parasites of global significance
... the liver via the blood. To enter the liver, the sporozoites must cross the fenestrated endothelial layer; however, the fenestrations are too small for the sporozoites to pass through, thus passage ...
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Cell specific expression of transforming growth factor beta in rat liver Evidence for autocrine regulation of hepatocyte proliferation
... hepatocytes, sinusoidal endothelial cells, Kupffer cells (liver macrophages), and lipocytes (Ito or stellate cells) from normal and regenerating ...normal liver, TGF-beta ...
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CONTINUING PHARMACY EDUCATION SERIES: HEPATOTOXICITY A REVIEW
... induced liver injury usually involves the participation of a toxic drug or metabolite that either elicits an immune response or directly affects the biochemistry of the ...the liver, which accounts for the ...
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Distribution of heme oxygenase isoforms in rat liver Topographic basis for carbon monoxide mediated microvascular relaxation
... the sinusoidal tone through direct in- hibitory action on soluble guanylate cyclase (37) or inducible and neural NO synthases (38), or through activation of volt- age-gated calcium channels ...the ...
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Effects of video-conferencing on gaze behavior and communication
... When making the decision to have a conversation FTF or over video-conferencing we can be assured that choosing the latter likely will not result in a longer conversation with more words and interruptions. However, we ...
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