Liver toxicity
Systems biology for identifying liver toxicity pathways
... Briefly, toxicity-relevant genes were identified using genetic algorithm coupled partial least squares analysis (GA/PLS) and toxicity pathways were subsequently recon- structed based upon the expression of ...
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Hepatoprotective Effects of Cranberry Extract against Diclofenac Sodium Induced Liver Toxicity in Rats
... Cranberry is the best source of flavonols among 30 flavonol-containing plant foods studied [7], and the flavonol content of cranberry is almost twice as high as 12 other commonly consumed fruit juices, including ...
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Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina
... rat liver toxicity and carcino- genesis induced by dibutyl nitrosamine (DBN) precursors, and further characterized its un- derlying mechanisms of action in HepG2 cell ...severe liver injury and ...
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Evaluation of Hepatoprotective activity of Eriocaulon quinquangulare in vitro using porcine liver slices against ethanol induced liver toxicity and free radical scavenging capacity
... any toxicity on liver tissue over the con- centrations we ...against liver toxicity induced by acetaminophen (APAP) intoxication in ...
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The effect of acetaminophen nanoparticles on liver toxicity in a rat model
... produces liver damage in human and various animal ...of liver toxicity was compared by determi- nation of liver transferase enzymes such as alkaline phosphatase, aspartate aminotransferase, ...
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Early Nano Detection of Liver Toxicity and Injury
... of liver toxicity and prevention of irreversible damage is ...of liver toxicity in a faster and more convenient way, we used a Trans-Epithelial Electrical Resistance (TER) and Light ...
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Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report
... the liver by P450 oxidases, they are uncommon hepatic toxins [7], and it is suggested they can be used safely in patients with abnormal liver function without the need to modify dosage ...extensive ...
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IRON OVER LOAD INDUCED LIVER TOXICITY OF AQUEOUS LEAF EXTRACT OF CARICA PAPAYA IN RATS
... .As shown in figure there was a considerable increase in lipid peroxidation in iron over load group in liver toxicity model as compared to normal control. And there is a considerable decrease in lipid ...
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Protective Effect of Silybin in Rats Liver Toxicity
... on liver histology and the capacity of silybin to ameliorate the ...study. Liver toxicity was induced by dietary alcohol administration and CCl4 intra-peritoneal ...of liver tissues shows that ...
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Hemidesmus indicus Protects against ethanol-induced liver toxicity
... and liver glycogen contents, an increased A/G ratio, and decreased liver marker enzyme activities and ceruloplasmin ...the liver FT-IR bands for the experimental groups were found to be altered ...
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Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?
... acute liver failure in developed ...decreased liver glutathione, and induction of cytochrome P450 (CYP) isoenzymes responsible for the metabolism of paracetamol to its toxic metabolite N-acetyl- ...
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Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study
... with liver enzyme elevations were not withdrawn, there is some evidence in favour of attempting to re-introduce the same regimen following a treatment interruption, as opposed to immediately changing to a more ...
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Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice
... metabolites, but also attenuates anti-oxidative mechan- isms through nonenzymatic glycosylation of anti-oxidant enzymes [1]. The mechanism by which hyperglycaemia causes free radical generation and, thus, causes ...
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Subchronic oral toxicity of silver nanoparticles
... the liver in a 28-day oral toxicity study [9] and the liver and lungs in a 90-day inhalation study ...the liver as the target organ and the tissue distribution of silver originating from ...
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A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
... Maraviroc Approved HIV-1 Human CCR5 DB04835 Liver toxicity, skin rash, allergic reactions,.. flu-like symptoms.[r] ...
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Metabolon Presentation
... Issued and Pending patents for biomarkers of toxicity and diseases including: Cancer, Insulin Resistance, Liver disease and Liver toxicity.. Metabolytics Business[r] ...
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HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACTS OF PHALLUSIA NIGRA AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
... induced liver injury (DILI) is one of the most common causative factor that poses a major clinical and regulatory ...the liver. [2] Hepatitis is an inflammation of liver caused by certain ...the ...
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Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue
... proliferation, liver necrosis, increase of liver hyperplasia, and p53 signaling were identified (Figure ...to liver toxicity and their predicted role in gene modulators affected by cAgNPs, ...
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Nodular Regenerative Hyperplasia Secondary to Neoadjuvant Chemotherapy for Colorectal Liver Metastases
... other liver pathology. Liver function tests prior to and after administration of chemotherapy are depicted in Table ...remnant liver volume of only 18% was calculated by CT volumetry, preoperative ...
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Histopathological changes in the rat liver and kidney with references to nicotine toxicity
... It is concluded that nicotine administration in mice resulted in toxic effects in the liver and kidney of mice. The present findings clearly demonstrate that Green tea and guduchi is capable of inducing dose ...
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