LIVER X RECEPTOR
Original Article Chaihu Shugan Powder attenuates Liver Qi stagnation type of metabolic syndrome in spontaneously hypertensive rats by upregulating liver X receptor-alpha
... of Liver Qi Stagnation rat model and to observe the effects of Chaihu Shugan Powder on the main components of MetS and the expression of LXR mRNA in the liver ...of Liver Qi Stagnation model was ...
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Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage
... LXR: liver X receptor; MAP2: microtubule-associated protein 2; MCP-1: monocyte chemoattractant protein-1; MIP-2: macrophage inflammatory protein; MMP-9: matrix metalloproteinase-9; mNSS: modified ...
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Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2
... The liver X receptor (LXR) is an oxysterol-activated nuclear receptor ...retinoid X receptor (RXR), with which LXR forms an obligate heterodimer, LXR controls gene transcription ...
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Original Article Correlation of liver X receptor and abnormal metabolism in school-age children with obesity
... In recent years, studies have shown that mac- rophages are the main effector cells of the innate immune response and play an important role in the metabolism of lipids and cholesterol efflux. Liver X ...
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The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis
... Chronic diseases such as type 2 diabetes and the Metabolic Syndrome create enormous burdens on society. Epidemiological studies now strongly implicate intrauterine growth restriction (IUGR) for increasing the risk of ...
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Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism
... Pgp (P-glycoprotein, MDR1, ABCB1) is an energy-dependent drug efflux pump that is a member of the ATP-binding cassette (ABC) family of proteins. Preliminary studies have reported that nonspecific inhibitors of Pgp affect ...
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Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor
... (RCT), liver X receptor (LXR) is an attractive target for the treatment of ...hormone receptor–associated protein 80 ...models, liver-specific knockdown of TRAP80 ameliorated ...
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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
... of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4 + T cells, while LXR deficiency promotes Th17 differentiation in ...hydrocarbon receptor (Ahr) and inhibiting Ahr-controlled ...
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Original Article Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages
... Abstract: ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in reverse cholesterol transport and anti-atherosclerosis. Liver X receptor alpha (LXRα) can stimulate cholesterol efflux ...
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Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization
... receptors Liver X Receptor α (LXRα or NR1H3) and β (or NR1H2) have been shown to control cancer cell proliferation and to a lesser extent, cancer cell death, in vitro and in vivo, ...
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Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques
... The liver X receptor (LXR) agonist GW3965 is a promising therapeutic compound, since it induces reverse cholesterol transport in foam ...and liver lipid levels, inhibiting its clinical ...p32 ...
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Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism
... LXR: Liver X receptor; MAPK: Mitogen- activated protein kinases; MCP-1: Monocyte chemoattractant protein-1; NF- κ B: Nuclear factor kappa-light-chain-enhancer of activated B cells; RT- PCR: Real-time ...
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Liver X receptor activation induces apoptosis of melanoma cell through caspase pathway
... Six- to eight-week-old male C57BL/6 mice were sub- cutaneously injected with B16F10 melanoma cells at the dose of 10 6 cells (n = 5 mice per group). Tumor growths were monitored by caliper measuring every other day, and ...
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Liver X receptor α mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression
... The liver X receptor family of transcription factors (LXRα and LXRβ) is known to play a central role in the regulation of cholesterol homeostasis and lipid synthesis (24, ...
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Liver X Receptor: A novel therapeutic target
... The liver X receptors α and β are orphan nuclear receptors that are key regulators in maintaining cholesterol ...the liver X receptors also functions in lipid and carbohydrate metabolism, ...
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Liver X receptor-β improves autism symptoms via downregulation of β-amyloid expression in cortical neurons
... membrane receptor signals transmission, and involves in a variety of physiological processes includ- ing cell growth, development, division and death through regulation of cell transcription factors [32, ...
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Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages
... The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family of proteins that are critical for the control of lipid homeostasis in vertebrates ...
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Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain
... dogenous peroxidase at room temperature. To block nonspecific binding, sections were blocked in 3% BSA for 10 min, after which a biotin blocking system (Dako) was used to block endogenous biotin. Sections were then ...
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Excess Nitric Oxide Activates TRPV1-Ca2+-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α
... The LXR α− ABCA1 pathway is the most im- portant mechanism responsible for cholesterol efflux from macrophages to apoA1 and thus plays a central role in maintenance of cholesterol homeostasis of foam cells and ...
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Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
... “retrochalcones” (licochalcone A–E, echinatin) that are isolated and characterized from licorice, the root and stolon of the Glycyrrhiza plant (Leguminosae) (e.g., Glycyrrhiza glabra or Glycyrrhiza inflata) [27-29]. It ...
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