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Liver X receptor agonist

Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux

Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux

... acid receptor (RAR) and retinoid X receptor (RXR) are also known to induce ABCA1 ex- pression in macrophages ...LXR agonist, functioned synergistically to further enhance ABCA1 ex- pression ...

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Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist

Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist

... indistinguishable across all metrics, indicating that most if not all of the effects seen were attributable to doxo- rubicin. Consistently, estimated coefficients for GW3965 were more or less the same as those for the ...

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Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

... the liver, kidneys, heart, spleen, and lungs were collected and separately imaged with in vivo imaging system ...spleen, liver, and kidneys, and a small amount was recovered from the lungs and hearts ...

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Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage

Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage

... attenuated inflammation in microglia that were acti- vated by thrombin, which is rapidly produced following ICH and contributes to ICH-induced brain damage [2]. Our findings are in line with previous studies showing that ...

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Influence of Flaxseed on Some BiochemicalFactors, Antioxidant Activity and Expression ofABCG5 and ABCG8 Genes in the Liver ofDiabetic Rat

Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat

... The Liver X receptors (LXRs) are a part of the nuclear receptor family which are controlled lipid carbohydrate ...with liver X receptor agonist improved elimination of ...

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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

... proliferator-activated receptor γ (PPARγ) were reported to exhibit enhanced cigarette smoke (CS)-induced airway inflammation and emphysematous changes in the lungs ...an agonist of PPARγ, attenuated ...

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Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor

Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor

... agonist T0901317 (Figure 1A and Supplemental Figure 1; supple- mental material available online with this article; doi:10.1172/ JCI73615DS1). Compared with GST alone, 4 proteins bound specifically to GST-LXRα LBD ...

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The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis

The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis

... pertinent to the presented studies is that human and rat hepatocytes have been demonstrated to respond to the LXR agonist GW3965 quite differently through gene expression profile experiments 31 . For instance, LXR ...

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Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation

Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation

... the X-ray films with GS-700 Imaging Densitometer (GS-700, Bio-Rad Laboratories, Milan, Italy) and a computer program (Molecular Analyst, IBM), and standardized for densito- metric analysis to b-actin and Lamin B1 ...

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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra  and extrahepatic cholestasis

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra and extrahepatic cholestasis

... in liver damage, including necrosis, fibrosis, and cirrho- ...FXR agonist GW4064 could pro- tect against cholestatic liver ...of liver damage in cholestatic patients by decreasing the ...

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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

... partial agonist that displays no significant adverse events even with 28 consecutive days ’ administration compared with full agonists ...and liver size were not recognized in OVA/OVA/NEt-4IB mice compared ...

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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

... synthetic agonist GW4064 increased HFD-induced lipid accumulation in the liver, partially due to a significant reduction in BA pool size and energy expenditure ...the liver and intestine, but also in ...

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Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis

Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis

... fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in the ...fatty liver and nonalcoholic steatohepatitis (NASH), the latter being associated with a relatively ...

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Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2

Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2

... LXR agonist GW3965 during the effector phase of EAE delayed the onset of clinical disease and reversed the diminished expression of LXR-dependent reverse cholesterol transport ...LXR agonist treated ...

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Liver X receptor opens a new gateway to StAR and to steroid hormones

Liver X receptor opens a new gateway to StAR and to steroid hormones

... substantially modulates glucocorticoid synthesis (see the related article beginning on page 1902). LXRa deletion in mice increases the availability of adrenal cholesterol for steroid synthesis by decreasing the ...

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Liver X Receptor: A novel therapeutic target

Liver X Receptor: A novel therapeutic target

... to liver via HDL by stimulating the production of apolipoproteins and ABC ...LXR agonist treatment leads to increased HDL levels and decreased formation of atherogenic ...LXR agonist. LXR ...

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Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK mediated 
RXRα phosphorylation

Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK mediated RXRα phosphorylation

... nuclear receptor signaling, and we show by in vivo labeling and phosphoamino acid detection that As 2 O 3 phosphorylated RXRa in the N-terminal ABC region exclusively on serine ...

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Medicinally active dihalocyclopropanes

Medicinally active dihalocyclopropanes

... Estrogen Receptor Modulators ...estrogen receptor in breast tissue, however, in other tissues such as the endometrium, it behaves as an ...mixed agonist and antagonist activities of Tamoxifen are ...

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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1

DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1

... of receptor with ligand: Docking analysis was carried out using Auto Dock Vina ...The receptor protein (THRA1) was kept rigid, while ligands were set flexible to rotate and explore most probable binding ...

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The Liver X Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development

The Liver X Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development

... The liver X-receptors (lxrs) act as cholesterol sensors and participate in the regulation of lipid and cholesterol metabo- lism. The objective of this study was to determine the role of lxr during ...

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