Lobular carcinoma
www.ijcep.com /IJCEP1012011 Case Report Invasive pleomorphic lobular carcinoma, negative for ER, PR and Her/2neu - a case report
... invasive carcinoma with highly atypical tumor cells infiltrating in a trabecular and cord like pattern (Figure ...of lobular carcinoma in situ (Figure ...
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Retrospective study of infiltrating lobular carcinoma of breast with assessment of utility of p120 catenin /E-cadherin double immunostaining in the diagnosis
... germline mutations and epigenetic silencing by DNA methylation(43). In case of E- cadherin downregulation, α- and β-catenins are rapidly degraded via an adenomatous polyposis coli–dependent mechanism that ultimately ...
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Invasive lobular carcinoma of the male breast – a systematic review with an illustrative case study
... Cases of LBC in the National Cancer Institute’s Surveil- lance, Epidemiology, and End Results (SEER) 1973–2013 dataset were retrieved using SEER*Stat version 8.2.1 (National Cancer Institute, Bethesda, MD, USA). Cases ...
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EZH2 expression in invasive lobular carcinoma of the breast
... Invasive lobular carcinoma (ILC) was first described by Foot and Stewart [1] in 1941 and is the second most common histologic type of breast cancer, comprising 5% to 15% of newly diagnosed invasive ...
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Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report
... and lobular neoplasia. Tumor cell of lobular carcinoma tends to have a loss of expression of ...between lobular and ductal carcinoma ...classical lobular carcinoma ...
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Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer
... metastatic lobular carcinoma of the breast to the colorectum presents endoscopic and radiologic ap- pearance of linitis plastica-type lesion with circumferential stricture and wall thickening of the ...
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PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression
... With the advent of next-generation sequencing intra- tumoural heterogeneity has been found to be widespread in invasive cancer; however, there are few data on the intra-tumoural heterogeneity of in situ breast cancers. ...
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Sonomammographic characteristics of invasive lobular carcinoma
... ductal carcinoma of the usual “not otherwise specified” type. Invasive lobular carcinoma (ILC) is the second most common histologic type of breast carcinoma, accounting for approximately ...
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Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods
... Invasive lobular carcinoma (ILC) and lobular neo- plasia (LN) are two distinct conditions that still pose chal- lenges regarding to their classification, diagnosis and manage- ...atypical ...
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Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma
... invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal ...negative carcinoma (TNC), which showed higher inci- dence of high histologic grade than non-TNC (p = ...
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Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics
... Pleomorphic lobular carcinoma (PLC) retains the distinctive growth pattern of classic ILC but, as in its in situ counterpart (PLCIS), there is marked cellular atypia and nuclear pleomorphism relative to ...
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Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
... ductal carcinoma (IDC), knowledge about the clinical outcome of lobular carcinoma has been based on studies including relatively small numbers of ...of lobular carcinomas within the context of ...
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Associations between the standardized uptake value of 18F FDG PET/CT and the prognostic factors of invasive lobular carcinoma: in comparison with invasive ductal carcinoma
... ductal carcinoma (IDC), which comprises 72% to 80% of all invasive breast cancers ...Invasive lobular carcinoma (ILC) is the second most common breast cancer after IDC and accounts for 5% to 15% of ...
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The diagnosis and management of pre invasive breast disease: Pathology of atypical lobular hyperplasia and lobular carcinoma in situ
... The criteria for the histological diagnosis of ALH and LCIS are well established. LCIS is composed of a monomorphic population of usually small, round, polygonal or cuboidal cells, with a thin rim of clear cytoplasm and ...
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Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast
... and lobular breast cancer is generally ER+ (94% of the ILC cases in this study were ER+) with the majority of ILCs classified as luminal tumors [32], it is not surprising that the majority of SNPs that we found to ...
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Pleomorphic lobular carcinoma: is it more similar to a classic lobular cancer or to a high-grade ductal cancer?
... to the relative rarity of P-ILC, and studies usually have small sample sizes. It has been recently emphasized that patients with invasive LC, although presenting more frequently with multifocal and multicentric disease, ...
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IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma
... IDC and ILC have distinct histological characteristics and clinical outcomes, and molecular alterations that distinguish these breast cancer variants have been identified (7–9). Comparison of our data with published ...
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Molecular drivers of lobular carcinoma in situ
... atypical lobular hyper- plasia (ALH), a pre-invasive lesion with morphological features similar to LCIS, except with smaller, less dis- tended ...term lobular neoplasia (LN) has been adopted by many to ...
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Metastatic breast cancer to stomach: management and review of the literature
... A 63 year old lady diagnosed with invasive lobular carcinoma in 2012, underwent modified radical mastectomy of right breast. Histopathological examination revealed a pT3N2M0 disease and ER positive, PR and ...
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Significance of lobular intraepithelial neoplasia at margins of breast conservation specimens: a report of 38 cases and literature review
... invasive lobular carcinoma were not detected in a rou- tine mammogram but additional imaging modality such as ultrasound and MRI were done to detect the pre- sence of ...
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