Local anesthetics
New Updates Pertaining to Drug Delivery of Local Anesthetics in Particular Bupivacaine Using Lipid Nanoparticles
... Local anesthetics directly block transmission of pain sensation from nociceptive afferent ...nerves. Local anesthetic agents are injected directly, and their po- tency results from action on the ...
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Local Anesthetics and Antipsychotic Phenothiazines Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in Yeast
... of anesthetics remain unclear because of dif fi culty in explaining how structurally different anesthetics cause similar ...cerevisiae, local anesthetics and antipsychotic phenothiazines ...
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New procedure to synthesize silver nanoparticles and their interaction with local anesthetics
... three local anesthetics (procaine, dibucaine, or tetracaine) was ...of anesthetics, were evidenced by transmission electron microscopy ...the anesthetics could be described in terms of ...
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Review Article The development of local anesthetics and their applications beyond anesthesia
... a local anesthetic devel- oped by Hoechst AG (Germany) in ...oral local anesthesia [41]. The pain of the local submucosal anesthesia injec- tion is significantly weaker than that of lido- ...The ...
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Pain and efficacy of local anesthetics for central venous access
... nonequivalent local anesthetic concentrations, differing additives and their concentrations, or different injection ...of local anesthetics remains unclear, it is hard to predict which anesthetic ...
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Treatment of peripheral pain with low-dose local anesthetics by epidermal, epithelial and periosteal application
... Objectives: The efficiency of local anesthetics (LAs) in the treatment of peripheral pain is commonly attributed to their capacity to block the axon conduction of sensory nerves. LAs even in non-blocking ...
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The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons
... Local anesthetics (LAs) block the generation and propagation of action potentials by interacting with specific sites of voltage-gated Na + channels. LAs can also excite sensory neurons and be neurotoxic ...
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Use of lipid emulsion as an antidote in the treatment of intoxication by local anesthetics and other lipophilic drugs
... by local anesthetics or other lipophilic drugs, the technology being evaluated (I = action = fat emulsion used as an antidote), the alternatives compared technology (C = comparator = treatment) and the ...
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Precooling agents: A boon to local anesthetics
... 2005). Local anesthesia (LA) are frequently used in dental practice to reduce acute and chronic pain as well as facilitate atraumatic dental treatment, also administered in pediatric dentistry(Malamed SF ...that ...
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Application of nanogel systems in the administration of local anesthetics
... of local anesthetics using polymeric nanoparticles produced via various types of polymerization ...a local anesthetic drug of the amino ester group) is described and ...
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Local anesthetics for brain tumor resection: current perspectives
... of local anesthetics in patients undergo- ing craniotomy for brain tumor resection, which is a procedure that is carried out frequently in neurosurgical ...with local anesthesia or under local ...
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Efficacy of Parental Application of Eutectic Mixture of Local Anesthetics for Intravenous Insertion
... The biggest obstacle for parent application of EMLA may be the availability of the drug, especially in rural locations. This obstacle may be overcome by making EMLA available at a clinic visit before the date that the ...
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Effect of local anesthetics on viability and differentiation of various adult stem/progenitor cells
... In direct comparison between cell types, MSCs and DPSCs exhibited significantly higher AGC expressions with 0.25× LD than other cells, whereas PDLSCs showed the highest AGC expression wi[r] ...
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Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers
... drugs. Local anesthetics must permeate lipoid barriers such as nerve sheaths or perineuria for reaching the nerve fi ...of local anesthetics. The ability of local anesthetics to ...
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Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials
... adrenergic agonists are more commonly used as adjuvants in clinical practice. During the intrathecal or epidural administration, fentanyl has a more rapid onset and shorter duration of action than morphine, which has ...
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Long term results of therapeutic local anesthesia (neural therapy) in 280 referred refractory chronic pain patients
... with local anesthetics for diagnosis and therapy (indications in- clude functional disorders, inflammatory diseases and acute and chronic ...achieve local anesthesia (except for ...the local ...
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Original Article Dexmedetomidine can extend the duration of analgesia of levobupivacaine in transversus abdominis plane block: a prospective randomized controlled trial
... Concerns about the safety of the administra- tion of perineural dexmedetomidine with local anesthetics in nerve block have been conside- red. A preclinical study that demonstrated add- ing dexmedetomidine ...
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<p>Anesthetic Strategies in Oncological Surgery: Not Only a Simple Sleep, but Also Impact on Immunosuppression and Cancer Recurrence</p>
... Local anesthetics ef fi ciently inhibits the neural signal transmission, by blocking the voltage-gated sodium chan- nels (VGSC), assuring an effective intraoperative anesthe- sia and postoperative ...-units. ...
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EFFECTS OF EPIDURAL ANALGESI A WITH LOW-DOSE BUPIVACAINE AND FENTANYL ON THE PROGRESS OF LABOR AND MODE OF DELIVERY
... of local anesthetics used, labor duration (time elapsed between cervical dilation at 4-5 cm and delivery), and mode of delivery (spontaneous, instrumental, or CS) were ...
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Evaluation of the anesthetic effect of epinephrine-free articaine and mepivacaine through quantitative sensory testing
... The aim of the study was to investigate the analgesic ef- fect of tooth as well as the anesthetic numbing effect of soft tissue which is caused by local anesthetics as 4% articaine and 3% mepivacaine which ...
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