Locus coeruleus
Sex Differences In Μ-Opioid Regulation Of The Rat Locus Coeruleus
... There are sex differences in disease susceptibility, time of onset of symptoms, and drug responses. Notably, sex differences are particularly prominent in pain and opioid analgesic responses, with females being less ...
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Adolescent Development Determines the Effects of Agonistic Social Stress on Rat Behavior and Locus Coeruleus Physiology
... Many neural programs that shape behavior become established during adolescence and adverse events that impact on these programs can have enduring consequences for mental health. Here we show that repeated social stress ...
144
Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat
... adrenergic receptor subtypes for 3 d. Individual receptor subtype expression, as determined by radiolabeled ligand binding, was selectively decreased only by the appropriate antisense ODNs and not by the “scrambled” ...
6
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
... noradrenergic locus coeruleus neurons occurs during the prodromal phase of Parkinson ’ s disease and contributes to a variety of non-motor symptoms, ...first locus coeruleus α -synucleinopathy ...
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An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development
... + locus coeruleus cells without heat treatment, and a2 shows GFP quenching with heat in another section of the same ...e2, Locus coeruleus; f, hippocampus; g, piriform ...h2, Locus ...
17
Locus coeruleus lesions and PCOS: role of the central and peripheral sympathetic nervous system in the ovarian function of rat
... nucleus locus coeruleus (LC) plays a central role in the regulation of the sympathetic nervous system and synaptically connected to the preganglionic cell bodies of the ovarian sympathetic pathway and its ...
8
The Effect of Acute Intra Locus Coeruleus (LC) Microinfusion of Bupropion on Formalin-Induced Pain Behavior in Rat
... The Locus Coeruleus as A5, A6 aminergic cell group is a major source of noradrenergic projections to the dorsal horn and has a well-established role in pain modulation ...
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The Protective Effect of Vitamin E on Locus Coeruleus in Early Model of Parkinson's Disease in Rat: Immunoreactivity Evidence
... Fig. 1. Photomicrographs of typical frontal sections through the LC showing TH-immunohistochemically stained of LC (left side) and VMAT2 immunoreactivity stained neurons (right side), in SH (A and E), in L + V (B and F) ...
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Quantifying the contrast of the human locus coeruleus in vivo at 7 Tesla MRI
... the locus coeruleus at ...the locus coeruleus, whereas the volumes of the second 3T and the 7T session were used to quantify the contrast of the locus coeruleus with several ...
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Coordination Mechanism in Dopamine Neurons of the Substantia Nigra Pars Compacta and Norepinephrine Neurons of the Locus Coeruleus
... neuromelanin is a conjugated polymer, and quantum dot/conjugated polymer combinations have been reported in numerous independent studies to generate coherent electron conduction bands for solar photovoltaic applications. ...
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Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
... The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to ...
9
Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus
... Asparagine endopeptidase (AEP; gene name LGMN) is a lyso- somal endopeptidase that specifically cleaves its substrates after asparagine under conditions of acidosis (17). Recently, we reported that AEP acts as a ...
17
Pupillometry and P3 index the locus coeruleus– noradrenergic arousal function in humans
... The observation that large phasic pupil dilations were accompanied by poor task performance appears inconsistent with the prediction that large LC-NE phasic responses should be synchrono[r] ...
13
Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease
... Rodent and non-human primate investigations have revealed the importance of the ascending noradrenergic LC projection system for cognitive function [11, 16, 85]. Based on a series of seminal experiments, Aston-Jones and ...
14
Enhanced catecholamine transporter binding in the locus coeruleus of patients with early Parkinson disease
... Clini- cal inclusion criteria for subjects with PD were: (a) diag- nosis according to the UK Parkinson Disease Brain Bank criteria; (b) absence of any signs indicative for aty- pical par[r] ...
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Effect of temperature on chemosensitive locus coeruleus neurons of savannah monitor lizards, Varanus exanthematicus
... In contrast, there is a different chemosensitivity ratio between LC neurons activated or inhibited by CO2 across temperatures in savannah monitor lizards; therefore, we emphasize the nee[r] ...
9
Estimating Linkage Disequilibrium Between a Polymorphic Marker Locus and a Trait Locus in Natural Populations
... trait locus and genetic marker ...marker locus and the major trait ...marker locus and a locus underlying a quantitative trait as well as the relevant genetic parameters using the sample from ...
13
THE REGULATION OF WHITE LOCUS EXPRESSION: A DOMINANT MUTANT ALLELE AT THE WHITE LOCUS OF DROSOPHILA MELANOGASTER
... These recombinant chromosomes must be presumed to carry the zeste allele from the original wDZL chromosome and are indistinguishable from standard z f w+ chromosomes in that[r] ...
13
An Internal Rearrangement in an Arabidopsis Inverted Repeat Locus Impairs DNA Methylation Triggered by the Locus
... locus was cloned by making a DASH (Stratagene, La Jolla, phenotype due to accumulation of an early intermediate CA) library from BamHI-cleaved genomic DNA and screening in the tryptophan pathway. ...
12
Inferring Linkage Disequilibrium Between a Polymorphic Marker Locus and a Trait Locus in Natural Populations
... disease locus and each of a set of marker loci by the disequilibrium measure is related to the recombina- use of the composite likelihood principle (Devlin et ...
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