long-acting β2-agonists
A Systematic Review of Long-Acting β2-Agonists Versus Higher Doses of Inhaled Corticosteroids in Asthma
... keywords: long-acting b -2 agonists OR salmeterol OR formoterol OR indacaterol AND cor- ticosteroids OR fl uticasone OR budeso- nide OR ciclesonide OR mometasone OR beclomethasone OR fl unisolide OR ...
10
A comparison of tiotropium, long-acting β2-agonists and leukotriene receptor antagonists on lung function and exacerbations in paediatric patients with asthma
... This literature review compares the efficacy and safety of long-acting β 2 -agonists (LABAs), leukotriene receptor antagonists (LTRAs) and long-acting muscarinic antagonists (LAMAs) as a[r] ...
19
Role of indacaterol and the newer very long-acting β2-agonists in patients with stable COPD: a review
... very long-acting β2-agonists to be used as an inhaled bronchodilator for COPD and provides 24-hour therapeutic action, thus allowing once-daily ...the long-acting ...
8
β2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells
... a long-acting β2-agonist with a corticosteroid may be most beneficial for enhancing endogenous host defense func- tions of airway epithelial cells in COPD and asthma patients with a Th2 cytokine ...
9
Age and Risks of FDA-Approved Long-Acting β2-Adrenergic Receptor Agonists
... The overall incidence difference of the asthma compos- ite outcome (asthma-related death, asthma-related intubation, or asthma- related hospitalization) for all ages combined was 6.3 eve[r] ...
10
Effect of β2-adrenergic receptor gene (ADRB2) 3′ untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response
... length polymorphism has been identified in a ‘C’ nucleo- tide-rich region 23 bp downstream from the translation stop codon of ADRB2 in the poly-C repeat region [16]. Results from a case-control study in a multiethnic ...
9
Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection
... We conducted a retrospective analysis of the COPD patients diagnosed with NSCLC who underwent surgery at the Tazuke Kofukai Medical Research Institute, Kitano Hospital, between January 2007 and December 2014. The ...
6
Bench to bedside review: β2 Agonists and the acute respiratory distress syndrome
... (a long-acting β 2 -agonist) reduced the incidence of high-altitude pulmonary oedema in volunteers who were known to be at risk for this ...-adrenergic agonists may accelerate resolu- tion of ...
8
Long acting β2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant
... PDZ-inter- acting domain, Dudez et al [46] have demonstrated that TNF a increased the amount of wild-type CFTR but not mutant CFTR in detergent-resistant membrane micro- domains in which CFTR interacts with TNF a ...
15
Inhalation of β2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract
... β2-receptor agonists are frequently used in the treatment of ...of β2-adrenoceptors on smooth muscle cells ...cells, β2- receptors are also found on cells involved in the regula- tion of ...
10
Improved process for the preparation A Long acting β2 adrenergic agonist (LABA) Salmeterol and identification, characterization and control of its potential process impurity
... selective β2-adrenoreceptor agonist. It is clinically used as a long-acting inhaled bronchodilator for maintenance treatment of asthma and to control nocturnal ...
8
Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France
... Data were analyzed by overdispersed Poisson regres- sion with generalized additive models (GAMs). Using non-parametric smoothing functions, GAMs allow flex- ible control of the effect of trend and seasonal compo- nents ...
5
Patient perspectives in the development and use of long-acting antipsychotics in schizophrenia: focus on olanzapine long-acting injection
... and long-acting injectable “depot” preparations of antipsychotic medications have been used as an alternative to oral medication therapy for patients for whom adherence is a clinically significant problem, ...
11
Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β2-agonists in patients with atopic asthma
... This randomized, placebo-controlled, parallel-group Phase IIb study evaluated the efficacy and safety of add-on treatment with AZD1981, a selective orally active CRTh2 antagonist, [r] ...
14
<p>Comparative Effectiveness of Long-Acting GLP-1 Receptor Agonists in Type 2 Diabetes: A Short Review on the Emerging Data</p>
... The second class of incretin agents are the GLP-1 receptor agonists (GLP-1RAs). These are injectable pep- tides which are resistant to DPP-4 degradation, providing supra-physiological stimulation of the GLP-1 ...
6
Long-acting risperidone injection: efficacy, safety, and cost-effectiveness of the first long acting atypical antipsychotic
... from long- acting ...conventional long-acting antipsychotics (Adams et al 2001), specifically recruited non-compliant patients due to the difficulties in maintaining such patients in a study ...
28
Comparative study of inhaled steroids versus inhaled steroids plus long acting beta agonists in childhood asthma: a randomized controlled study
... 9. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'byrne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in ...
5
Long-acting preparations of exenatide
... of long-acting preparations is univer- sal technologies that can be applied to a series of proteins or peptides (such as XTEN technology) and in combination with gene therapies, we can achieve a once and ...
8
Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action
... AZD3199 has i.v. plasma terminal half-lives of 11, 17 and 18 h in rats, guinea pigs and dogs respectively and combined with high volumes of distribution (Vz) 23 (rats), 22 (guin- ea pigs) and 17 (dogs) L/Kg afforded ...
7
Long-acting beta-agonists reduce mortality of patients with severe and very severe chronic obstructive pulmonary disease: a propensity score matching study
... Results: The pre-matching cohort was comprised of 591 patients (50.6% were administered long-acting beta-agonists. Age: 66.6 ± 5.3 year old. Female: 35.4%. Forced expiratory volume in one second ...
8