Lower Esophageal Sphincter
The lower esophageal sphincter (LES)
... enhancement of other mechanical factors. d. The fact that there is an overlap in the LES pressure values between symptomatic and asymptomatic patients suggests the role of factors other than LES pressure alone. For a ...
9
Mechanics of Sphincter Action STUDIES ON THE LOWER ESOPHAGEAL SPHINCTER
... of lower esophageal sphincter ...the lower esophageal sphincter as a function of the inside ...rat lower esophageal sphincter in ...the lower ...
7
Pharmacologic identification of the lower esophageal sphincter
... the lower esophageal ...The sphincter is defined, at least in part, in the esophageal wall rather than in the central nervous ...the lower esophageal ...
12
Outcomes of esophageal surgery, especially of the lower esophageal sphincter
... of esophageal surgery, including the mechanisms by which fun- doduplication improves lower esophageal sphincter (LES) pressure; the efficacy of the Linx TM management system in improving LES ...
14
Mechanism of action of pentagastrin on the lower esophageal sphincter
... The effects of pentagastrin on lower esophageal sphincter (LES) pressure has been studied in trained, unanesthetized dogs. LES pressure was monitored by an infusion manometric technique. Increasing ...
9
Nature of the vagal inhibitory innervation to the lower esophageal sphincter
... the lower esophageal sphincter in the anesthetized ...opossum. Sphincter relaxation with electrical stimulation of the vagus was not antagonized by atropine, propranolol, phentolamine, or by ...
9
Vasoactive intestinal polypeptide A neurotransmitter for lower esophageal sphincter relaxation
... the lower esophageal sphincter region was incubated in solution that contained 12-25 parts of VIP antiserum per 1,000 to Tyrode's solution, while a second strip was incubated in a solution of normal ...
6
Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia
... J Clin Invest. 1971;50(6):1241-1247. https://doi.org/10.1172/JCI106601. Intraluminal manometric studies were carried out in 19 patients with untreated achalasia and in 20 normals. Lower esophageal ...
8
Experimental induction of isolated lower esophageal sphincter relaxation in anesthetized opossums
... Isolated lower esophageal sphincter (LES) relaxation, defined as a transient sphincteric relaxation unaccompanied by esophageal peristalsis, has been shown to precede most episodes of ...
8
Pressure tension, and force of closure of the human lower esophageal sphincter and esophagus
... J Clin Invest. 1975;56(2):476-483. https://doi.org/10.1172/JCI108114. The mechanical characteristics of the circular muscle of the human lower esophageal sphincter and esophagus were studied in ...
9
Mechanism of the Lower Esophageal Sphincter Relaxation ACTION OF PROSTAGLANDIN E1 AND THEOPHYLLINE
... J Clin Invest. 1973;52(2):337-341. https://doi.org/10.1172/JCI107189. The intravenous injection of prostaglandin E 1 (PGE 1 ) causes a dose-dependent relaxation of the lower esophageal sphincter ...
6
Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin
... human lower esophageal sphincter competence, was studied in 54 normal ...the lower esophageal sphincter, was constructed from the rapid intravenous injections ...
7
Electrical and mechanical activity in the human lower esophageal sphincter during diaphragmatic contraction
... the lower esophageal sphincter (LES) pressure, we studied eight healthy volunteers during spontaneous breathing, maximal inspiration, and graded inspiratory efforts against a closed airway (Muller's ...
9
The Adrenergic Control of Lower Esophageal Sphincter Function: AN EXPERIMENTAL MODEL OF DENERVATION SUPERSENSITIVITY
... of lower esophageal sphincter (LES) function, LES pressure, LES relaxation during swallowing, and blood pressure were measured in the anesthetized opossum, Didelphis virginiana, during intravenous ...
9
The Genesis of Lower Esophageal Sphincter Pressure: Its Identification through the Use of Gastrin Antiserum
... J Clin Invest. 1972;51(3):522-529. https://doi.org/10.1172/JCI106840. The purpose of this study was to evaluate the role of gastrin in the genesis of lower esophageal sphincter (LES) pressure by the ...
9
Effects of 5 hydroxytryptamine on the lower esophageal sphincter in vivo: evidence for multiple sites of action
... the lower esophageal sphincter in the ...the sphincter was 0.5 mug/kg, and a maximal sphincter contraction was produced by a dose of 40 ...the sphincter pressure; maximal ...
10
Effect of continuous infusion of pentagastrin on lower esophageal sphincter pressure and gastric acid secretion in normal subjects
... Bolus injections of gastrin or pentagastrin (PG) cause a marked elevation in lower esophageal sphincter pressure (LESP), and it has been suggested that serum gastrin concentration is the[r] ...
9
Sympathetic Control of Lower Esophageal Sphincter Function in the Cat: ACTION OF DIRECT CERVICAL AND SPLANCHNIC NERVE STIMULATION
... Jacques Fournet, … , William J. Snape Jr., Sidney Cohen J Clin Invest. 1979;63(4):562-570. https://doi.org/10.1172/JCI109337. The purpose of this study was to determine the effect of direct stimulation of the sympathetic ...
10
Manometric Diagnosis of Lower Esophageal Sphincter Incompetence in Infants: Use of a Small, Single-Lumen Perfused Catheter
... Pressure tracing obtained from 3-month-old infant with chronic vomiting secondary to lower esophageal sphincter incompetence as catheter is withdrawn from stomach, through lower esophage[r] ...
6
A prospective case control study of the Lower Esophageal Sphincter Pressure in patients with Type II Diabetes Mellitus presenting with heartburn
... the lower esophageal sphincter as increased pressured ...of esophageal manometry can accentuate the physiological features such as the position of the diaphragm or presence of the ...
157