LOX-1
A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL
... molecule; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; LJ, Lady Joy; LDL, low density lipoprotein; Lys LJ, Lady Joy lysate; MDA, malondialdehyde; M199, medium 199; NF-kB, nuclear ...
11
Original Article The association of LOX-1 rs1050283 polymorphism with renal hypertension susceptibility in a Chinese population
... of LOX 1 and cardiovascular ...in LOX 1 3’-UTR which was involved in the susceptibility to coronary artery ...the LOX-1 3’UTR 188 CT TT genotype was positively associated with ...
8
<p>LOX-1+ PMN-MDSC enhances immune suppression which promotes glioblastoma multiforme progression</p>
... receptor 1 (LOX-1) may serve as a speci fi c marker of human PMN-MDSC, and could be used to speci fi cally identify ...of LOX-1+ PMN-MDSC in GBM ...
9
Nuclear Role of LOX-1 in XinMaiJia-attenuating Atherosclerosis in Rabbits
... Endothelin (ET) is a peptide composed by 21 amino acids. ET was isolated from the porcine aortic ECs by Yanagisiawa in 1988. Many tissues in vivo could synthesise ET. The ECs could produce ET-1, exhibiting the ...
9
Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population
... in LOX-1 gene and cerebral infarction in Chinese popu- lation? 1) LOX-1 is involved in endothelial activation and dysfunction, monocyte adhesion, the proliferation, migration, and ...
6
Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E
... incremental LOX-1 expression and ROS, the a -SMA was increasingly expressed and was accompanied with a reduction of E- cadherin, the cells began ...the LOX-1 or with NAC to suppress the ROS ...
7
LOX-1-deficient mice are resistant to zymosan-induced arthritis: A mini review
... Wild-type (WT) and LOX-1 KO mice (n=10, in each) were used, and we injected with zymosan to induce arthritis (180 μg/6 μL; Sigma-Aldrich, St. Louis, MO, USA). We observed at the time point of 24, 48 and 72 ...
6
Modulation of Nitric Oxide Synthases by oxyLDL: Role in Vascular Inflammation and Atherosclerosis Development
... that LOX-1 activation by L5, an electronegative component of LDL abundant in dyslipidemic but not in normolipidemic human plasma, selectively inhibited Bcl-xL and anti-apoptotic Bcl-2 expression and Akt and ...
20
Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis
... mRNA expression; however, mRNA expression changes do not always result in protein content changes (39). Determining protein expression by western blot analysis is recommended for future experiments. Second, ...
8
Original Article Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1
... of LOX-1 were significantly decreased with the administration of losartan in LPS-induced lung ...by LOX-1 in LPS-induced lung ...of LOX-1 in LPS-induced lung ...
7
Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies
... the expression of MCP-1, VCAM-1 and LOX-1 [77,85]. Thus, elevated levels of homocysteine may lead to hyper- tension by mechanisms similar to that of angiotensin II. This hypothesis is further ...
19
Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation
... China), 1 mM phenylmethanesulfonyl fluoride (Beyotime, China), and 10% PhosSTOP (Roche, ...Technology), LOX (1:1000, Abcam), LOXL1 (1:1000, Abcam), LOXL2 (1:1000, Abcam; 1:2000, ...
12
Diet induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto transplantation model
... the LOX-1 receptor, highlighting a pathophysiological mechanism starting at an early stage, in the absence of chronic injury and without detectable change on the mo- nitoring of the renal ...or ...
11
Construction of adenovirus vectors through Cre-lox recombination.
... FIG. 2. (a) Restriction mapping of Adb-gal and C5 DNA coinfected into 293 or CRE8 cells. For each cell type, total low-molecular-weight (Hirt) DNA or packaged DNA was prepared and digested with BsaBI or ClaI and resolved ...
8
ANTIFUNGAL ACTIVITY OF OXYLIPINS AGAINST PAPAYA FUNGAL PATHOGENS Sujatha B, Rashmi HK and P. Uma Maheswari Devi*
... Papaya LOX Hydroperoxides and Hydroxides by Filter disc method Antifungal activity of LOX hydroperoxides and hydroxides of LA (13-HPOD, 9-HPOD, 13-HOD and 9-HOD) and ALA (13- HPOT, 9-HPOT, 13-HOT and 9-HOT) ...
7
Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats
... effective inhibition of cPLA2 was shown by reduced levels of LPC and FFA, products of PC hydrolysis by cPLA2, in CEC + ATK (Figure 4). LPC and FFA had similar patterns of results, suggesting that both may have originated ...
12
The potential for targeting extracellular LOX proteins in human malignancy
... of LOX have been shown to be independent of its enzymatic function, selective inhibitors of LOX catalytic activity should leave any tumor suppressor function ...the LOX family active sites and by the ...
7
Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... The test was conducted according to method based on previous published study [30]. Briefly, 0.1 ml carra- geenan was injected into the sub-plantar region of the left hind-paw of each rat. The volume (ml) of induced edema ...
7
A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans
... serpine 1 (SER- PINE 1, combined OR ...alpha 1 type IV collagen (COL4A1, combined OR ...the LOX gene and IA was ...the LOX gene ...
6
Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
... of LOX-family members in human PDAC might be involved in the well-known chemoresistance of ...compared LOX family member expression in Colo-357 and MIA Paca-2 PDAC-derived cell ...of LOX family ...
13