Lox, The
The potential for targeting extracellular LOX proteins in human malignancy
... the LOX proteins participate in every stage of cancer progression, and two family members, LOX and LOX-like 2, have been linked to metastasis, the final stage of cancer respon- sible for over 90% of ...
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Site-specific recombinatorics : in situ cellular barcoding with the Cre Lox system
... 1 Lox biology and Lox barcode cassette. a Lox DNA ...sequences. Lox sites are composed of two 13 bp palindromic Cre binding sites and an 8 bp core (original LoxP sequence ...two Lox ...
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<p>Eicosapentaenoic acid’s metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer</p>
... miRNAs are pivotal mediators of carcinogenesis and CC progression. 25,26 To our knowledge, the mechanism under- lying dietary induction of CC is still unclear. In a previous study, 27 we con fi rmed the strong association ...
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Original Article Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer
... of LOX, an extracellular matrix-remodeling enzyme, was found to be significantly associat- ed with MMP2/MMP9 expression in a variety of human ...with LOX expression in breast cancer [15]. It has also been ...
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Muscle composition is regulated by a Lox TGFβ feedback loop
... between Lox, a myofiber-secreted enzyme, and TGF β , a cytokine acting in the MCT on myofibers and fibroblasts to inhibit myogenesis and promote MCT development, is at the heart of these dual ...of Lox the ...
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ANTIFUNGAL ACTIVITY OF OXYLIPINS AGAINST PAPAYA FUNGAL PATHOGENS Sujatha B, Rashmi HK and P. Uma Maheswari Devi*
... tissues. LOX metabolites acts as an antimicrobial compounds leading to the development of ...of LOX, the fatty acid hydroperoxides, are very reactive and cause oxidative damage to membranes, leading to cell ...
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Construction of adenovirus vectors through Cre-lox recombination.
... Since high selection efficiency was critical for the success of our virus-building plans, we performed a detailed analysis of C5 growth (Fig. 2a). When C5 was grown in cells making Cre recombinase, over 90% of the ...
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Novel functions of LHX2 and PAX6 in the developing telencephalon revealed upon combined loss of both genes
... CreER;Lhx2 lox/lox ;Pax6 lox/lox animals recapitulates the results we obtained from the respective single and double null mutants by ...Lhx2 lox/lox ;Pax6 lox/lox ...
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A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans
... the 44 potential candidate genes of ECM integrity in a Dutch population in developing IA. They reported that serpine 1 (SER- PINE 1, combined OR 1.27, p=0.004), FBN2 (combined OR 1.37, p=0.01), and alpha 1 type IV ...
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Diet induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto transplantation model
... Background: In kidney transplantation, the prevalence of hypercholesterolemia as a co-morbidity factor known to affect graft function, is rising due to the increased number of older donors in response to organ shortage ...
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BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype
... L. mexicana (MYNC/BZ/62/M379) was maintained by serial passage of amastigotes inoculated into the shaven rumps of BALB/c mice. Amastigotes for use in infections were isolated from lesions and enumerated as described ...
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IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells
... Recently, a pivotal role for IL-4 and IL-4Rα-responsive B cells in the non-healing response of BALB/c mice infected with L. major has been demonstrated (25). Abrogation of IL-4R α signaling on B cells in BALB/c mice (mb1 ...
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Synthesis of novel 1,2,4 triazoles and their evaluation of 5 LOX inhibition and antimicrobial activity
... The in vitro anti-inflammatory activity of the target compounds (6a-e) were carried out according to the method described by Lip Yong Chung [16] employing “Curcumin” as standard. The 5-LOX inhibition assay was ...
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Human colorectal cancer progression correlates with LOX-induced ECM stiffening
... that LOX overexpression increases tumor stiffness in spontaneous insuloma of Rip1-Tag2 mice and that the tumor stiffening participates in the whole tumorigenesis ...of LOX expression. Also, a LOX ...
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Efficient Generation of Recombinant Adenoviral Vectors by Cre-lox Recombination In Vitro
... Using the Cre-loxP reaction, we prepared full- length recombinant adenoviral DNA in vitro by recombination between a shuttle plasmid and adenovirus genomic DNA that was previously trunca[r] ...
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Nuclear Role of LOX-1 in XinMaiJia-attenuating Atherosclerosis in Rabbits
... Endothelin (ET) is a peptide composed by 21 amino acids. ET was isolated from the porcine aortic ECs by Yanagisiawa in 1988. Many tissues in vivo could synthesise ET. The ECs could produce ET-1, exhibiting the strong and ...
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LOX-1-deficient mice are resistant to zymosan-induced arthritis: A mini review
... All data have been presented as mean ± standard deviation. The scores of each group (n= 10) were compared using Student’s t-test. P-values less than 0.05 were considered significant. All data were analyzed with Stat Mate ...
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Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor
... The impairment of glucose tolerance in Igf1r lox/– and Igf1r ∆lox/– mice is apparently not due to insulin resistance, since insulin tolerance tests failed to demonstrate differences betw[r] ...
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Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
... used: LOX 5ʹ-ggatacggcactggctactt-3ʹ and 5ʹ-gacgcctggatgtagtaggg- 3ʹ, LOXL1 5ʹ-gccagtggatcgacataacc-3ʹ and 5ʹ-ccaaaacaat atactttgggttca-3ʹ, LOXL2 5ʹ- tgacctgctgaacctcaatg-3ʹ and 5ʹ-tggcacactcgtaattcttctg- 3ʹ, ...
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Targeting lysyl oxidase for molecular imaging in breast cancer
... the LOX family was analyzed at the transcript level via microarray analysis using tissue biopsy samples from 176 patients with breast ...substrate-based, LOX-targeting ...
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