LPL, lipoprotein lipase
Molecular studies on primary lipoprotein lipase (LPL) deficiency One base deletion (G916) in exon 5 of LPL gene causes no detectable LPL protein due to the absence of LPL mRNA transcript
... primary lipoprotein lipase (LPL) deficiency in a proband TN and his affected brother SN, both manifesting familial ...Neither LPL activity nor immunoreactive LPL mass was detected in ...
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Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
... Our data demonstrate that myocyte-associated LpL leads to increased lipid uptake. This finding indicated that either nonlipolyzed or partially lipolyzed particles crossed the endothelial lining of the cardiac ...
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AN HUGE UPDATED REVIEW ON DYSLIPIDEMIA ETIOLOGY WITH VARIOUS APPROACHES FOR ITS TREATMENT
... enzyme LPL hydrolyzes the TG and free-fatty acids are ...periphery. LPL: lipoprotein lipase, FFA: free fatty acids, VLDL: very low density lipoproteins, IDL: intermediate density Lipoproteins, ...
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Lipoprotein Lipase and Hydrofluoric Acid Deactivate Both Bacterial Lipoproteins and Lipoteichoic Acids, but Platelet-Activating Factor-Acetylhydrolase Degrades Only Lipoteichoic Acids
... 55). Lipoprotein inactivation is commonly achieved by deacylation with a lipoprotein lipase (LPL) or by oxidation with hydrogen peroxide (H 2 O 2 ) (22, 24, ...
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KINETIC STUDIES ON METABOLISM OF LIPOPROTEIN LIPASE
... Coefficient and exponential constants of lipoprotein lipase LPL activity curve in human subjects, dogs, and rabbits injected with heparin, 0.1 mg per kg of body weight K*.. Mean Acute he[r] ...
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Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia No evidence for a triglyceride rich precursor of lipoprotein(a)
... lipoproteins to low-density lipoproteins. Considering apo(a) type, the plasma concentration of apo(a) was normal in type III patients but significantly reduced in LPL deficiency. Despite the defects in the ...
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A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries
... Lipoprotein lipase (LPL) plays a crucial role in the regulation of lipoprotein metabolism by hydrolysing the core triglycerides of circulating chylomicrons and ...human LPL gene is now ...
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Fat cell metabolism in different regions in women Effect of menstrual cycle, pregnancy, and lactation
... and lipoprotein lipase (LPL) activity were studied in biopsies from the femoral and abdominal depots in healthy women during early or late menstrual cycle, pregnancy, and the lactation ...
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Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities
... the lipoprotein lipase (LPL) gene (8 heterozygous and 8 normal subjects), carrier status for the mutation as determined by DNA analysis was related to LPL activity in postheparin plasma, to ...
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Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte derived macrophages
... nonadherent cells, the adhered monocytes were cultured in RPMI 1640 supplemented with 100 U/ml penicillin, 100 m g/ml streptomycin, 10% FCS, and 10% human serum. Every 2 d, the medium was changed. After 7 d, the cells ...
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Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study
... and LPL to IR and T2D Table 4 presents association parameters (OR and 95% CI) of serum 25(OH)D and LPL with IR and T2D from logistic regression ...of LPL which was positively associated with serum ...
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A low-carbohydrate high-fat diet decreases lean mass and impairs cardiac function in pair-fed female C57BL/6J mice
... 3 Female C57BL/6J mice fed a low-carbohydrate high-fat (LCHF) diet showed lower lipoprotein lipase (LPL) activity in the subcutaneous (SC) and perigonadal (PG) white adipose tissue than [r] ...
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Lipoprotein lipase levels in patients with Coronary Artery Disease with Type 2 Diabetes Mellitus
... of lipoprotein enter the circulation in order to distribute TAG to tissues also preventing the dispersal of the lipid en route by exchange or diffusion, the lipoproteins also confer the ability to deliver lipids ...
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Lipoprotein lipase and obesity
... tein lipase (LPL) activity in skeletal muscle would cause an improvement of ...the LPL activator NO-1886 in obese animals. NO- 1886 elevated LPL activity in skeletal muscle, and improved ...
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Amino acid substitution (Ile194 Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands Support for a multicentric origin
... of lipoprotein lipase (LPL) deficiency have been facilitated by the availability of LPL gene probes and the recent characterization of gene mutations underlying human LPL ...the ...
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Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig
... high-density lipoprotein cholesterol were decreased (P < ...of lipoprotein lipase(LPL), fatty acid translocase/cluster of differentiation (FAT/CD36), fatty acid binding protein (FABP3) and ...
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Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk
... low-density lipoprotein cholesterol (LDL-C) [1], and is consequently associated with an increased cardiovascular disease (CVD) risk ...and lipoprotein lipase (LPL) genotypes ...
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Genetic basis of lipoprotein disorders
... These include the apolipoproteins, A-I, A-II, A-IV, B, CI, CII, CIII, D, E, and apoa, the lipoprotein processing proteins, lipoprotein lipase LPL,1 hepatic triglyceride lipase HTGL, leci[r] ...
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Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones sensitive lipase in human subcutaneous abdominal adipocytes
... In summary, in subcutaneous abdominal adipocytes isolated from women, the progestogens increased LPL protein expression and reduced HSL protein expression relative to control. Similar effects were observed with ...
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Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency
... the lipoprotein lipase (LPL) gene from five unrelated Japanese patients with familial LPL ...plasma LPL mass was either virtually absent (patients 1 and 2) or significantly decreased ...
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