LTA, lipoteichoic acid
Toll-like receptors activation, signaling, and targeting: an overview
... repeats; LTA: Lipoteichoic acid; miRNAs: MicroRNA inhibitors; mtDNA: Mitochondrial DNA; MyD88: Myeloid differentiation primary- response protein 88; MAPK: Mitogen-activated protein kinase; NAHNP: ...
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Peptidoglycan and Lipoteichoic Acid Modify Monocyte Phenotype in Human Whole Blood
... The up-regulation of ICAM-1 on macrophages by endotoxin was recently shown to involve activation of the transcription factor NF-B (32). This ubiquitous transcription factor is also induced in macrophage-like cell lines ...
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Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis
... Peptidoglycan biosynthesis and remodeling are also important steps in cell division and in the overall maintenance of the cell wall (reviewed in reference 42). Cell wall maintenance requires the activity of multiple ...
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Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG
... the LTA structure of LGG in mediating pro- inflammatory effects in dedicated cell ...modified LTA of LGG. First, we showed that LGG LTA is able to activate NF-κB in HEK293T cells via interaction with ...
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R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae
... We show that R-roscovitine strongly re- duces acute lung inflammation induced by LTA. Postponed administration of this compound after induction of gram- positive pneumonia similarly reduced PMN counts in lungs, ...
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Experimentally induced subclinical mastitis: are lipopolysaccharide and lipoteichoic acid eliciting similar pain responses?
... nents, lipoteichoic acid (LTA) and lipopolysaccharide (LPS), deriving from Staphylococcus aureus and Escheri- chia coli respectively, are commonly infused in the bovine mammary gland to elicit ...
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Original Article Lipoteichoic acid of Streptococcus sanguinis induces the expression of cyclooxygenase-2 via MAPK signaling pathways in H9c2 cells
... Cells were plated onto 60 mm tissue-culture dishes and stimulated with LTA or inhibitors for the indicated time period. The cells were then washed with ice-cold PBS, lysed and then cen- trifuged at 13,000 g for 10 ...
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Platelet-Activating Factor-Acetylhydrolase Can Monodeacylate and Inactivate Lipoteichoic Acid
... is lipoteichoic acid (LTA), which is a polyphosphate poly- mer linked to a glycerol backbone with two acyl ...the LTA molecule to the bacterial plasma membrane like the acyl chains of ...
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The immunomodulatory role of lipoteichoic acid from probiotic bacteria : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry, Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand
... of LTA from HN001, then either the shortened PGP length and/or the greater GlcNAc substitution may be responsible for the weaker activity of Pool ...plantarum LTA, which contains no GlcNAc but rather ...
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Staphylococcal lipoteichoic acid inhibits delayed type hypersensitivity reactions via the platelet activating factor receptor
... to LTA or CPAF inhibited delayed-type hypersensitivity (DTH) reactions to the chemical dinitrofluorobenzene only in PAF-R–expressing ...of LTA that were adequate to stimulate PAF-R in vitro on the skin of ...
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Lipoteichoic Acid Inhibits Interleukin-2 (IL-2) Function by Direct Binding to IL-2
... by LTA does not require accessory cells or involve a reduction in T-cell ...of LTA on cells other than T ...Alternatively, LTA may be toxic to T cells, thereby also reducing IL-2 production and ...
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Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells
... Chemokines regulate migration and adhesion of infil- trating cells to an inflamed lesion [28], and inhibition of chemokine expression or secretion significantly re- duces cell infiltration [29]. Resident tissue cells ...
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The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone
... in LTA-depleted ...depleting LTA in cells that lack clpX, ...that LTA becomes nonessential when ClpX is inactivated (see ...of LTA was observed both in the presence and the ab- sence of an ...
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Circulating microRNA signatures in mice exposed to lipoteichoic acid
... and LTA exposure as promising biomarkers at the very first step; however, further investi- gation is required to understand the location of expressed miRNAs in the circulation and to clarify their origins and ...
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Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health
... D-alanyl LTA, to ensure that these antibodies were not unique to dental or Okla- homa populations and to examine whether the antibody concentration was sex or ...
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Lipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway
... [12,13]. LTA can stimu- late inflammatory responses in the lung ...regulate LTA-mediated cell activation is crucial for diagnosis, treatment, or progno- sis of lung inflammatory ...stimuli, LTA can ...
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Current knowledge and future directions of TLR and NOD signaling in sepsis
... The immune system affords the host an opportunity to respond to pathogenic microorganisms and incorporates innate and adaptive immunity. Innate immunity is a generic response to the recognition of invading micro- bial ...
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Mechanism of gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure
... nents LTA and PepG from ...that LTA or PepG from ...the LTA and PepG–teichoic acid complex from ...and LTA from ...the LTA structure for synergy among the cell wall compo- nents ...
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Bacterial lipoteichoic acid sensitizes host cells for destruction by autologous complement
... pneumococcal LTA (LTA-E) were used as a model system to determine if LTA could render host cells susceptible to damage by autologous ...of LTA-E from normal rats and normal humans occurred ...
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Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid
... expressing LTA and purified S. aureus-LTA induce intestinal immune activation resulting in the produc- tion of TNFa and IL-12 and the development of pro- inflammatory cells such as CD11c + TNFa + IL-12 + ...
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