Luminal B
Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2 negative) intrinsic breast cancer subtypes
... most of whom the use of cytotoxic drugs would not be recommended, might have actually received and benefited from adjuvant chemotherapy. Still, only a small proportion (18.5%) of women with luminal A–like breast ...
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Luminal B breast cancer: patterns of recurrence and clinical outcome
... of luminal B breast cancer were compared with 189 cases of non-luminal breast cancer, and it was found that the median age at diagnosis was greater (48:42) and that the proportion of postmenopausal ...
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MRI texture analysis in differentiating luminal A and luminal B breast cancer molecular subtypes - a feasibility study
... subtypes luminal A and luminal B. Luminal A is associated with lower Ki-67 rate than subtype luminal ...thereby luminal B type cancers might show more heterogeneous ...
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Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.pdf
... were luminal A, 84 were luminal B, and 25 were luminal – HER2-positive tumors from patients who received com- bined adjuvant ...with luminal A tumors, 51% (95% CI = 42% to 63%) for ...
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Luminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype
... the luminal B (HER2+), HER2, and basal-like ...the luminal A or luminal B (HER2-) subtypes, and a con- siderable number of aneuploid/CIN+ tumors were also included in these two ...that ...
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Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT
... in luminal B breast cancer and as a tumor suppressor in claudin-low ...non-migratory luminal B cells, Rab25 may increase the migration ...in luminal B tumors while it opposes EMT ...
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MYC regulation of Glutamine Proline regulatory axis is key in Luminal B breast cancer
... with luminal B ...(Luminal B) compared with ER+/HER2- low proliferation class (Luminal A) ...in Luminal B tumours only ...
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Luminal B breast cancer and novel therapeutic targets
... reproduced luminal-A and luminal-B ...the luminal epithelial component of the breast, including expression of luminal cytokeratins 8/18, ER and genes associated with ER activation such ...
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The molecular profile of luminal B breast cancer
... the luminal A and luminal B subtypes of ER+ breast cancer, with luminal B cancers showing a more aggressive phenotype including substantially worse outcomes in ...The luminal ...
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Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco
... Therefore, Luminal B subtype was more prevalent (41.8%), followed by luminal A ...The luminal B subtypes present a higher median tumor size (T2 and T3) as like basal-like and ...The ...
7
Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients
... and luminal B breast cancers including age, tumor size, grade, ki67 value, tumor stage, nodal status, and laterality were ...of luminal B subtype was notably higher in a younger age group as ...
6
EO771, the first luminal B mammary cancer cell line from C57BL/6 mice
... the luminal subtype which nevertheless represents the majority of breast cancers encountered in ...the luminal B subtype and derived from the strain ...
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Tailored targeted therapy for all: a realistic and worthwhile objective?
... Breast cancers have more recently been separated into five distinct classes based on gene expression profiles (Figure 1): the luminal A and luminal B classes, the HER2 and basal classes, and, ...
5
Functional characterization of breast cancer using pathway profiles
... A, luminal B, triple-negative and HER2+) as examples, we examine the new approach from three per- spectives: to determine whether the pathway profile can be reproduced from the data generated by different ...
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Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.
... HER2, Luminal A, Luminal B and Basal breast cancer subtypes in the METABRIC cohort (data not shown), indicating the general applicability of the in vitro cell adhesion phenotypic screen to discover ...
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LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer
... (i.e., luminal A, luminal B, basal-like, and Her-2 +) in 2005 [6]; 2) In 2009, TNBC was identified as resulting from chromosomal abnormalities, such as chromosomal band deletion of PTEN/RASA1 and ...
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Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer
... HER2, Luminal A, Luminal B and Basal breast cancer subtypes in the METABRIC cohort (data not shown), indicating the general applicability of the in vitro cell adhesion phenotypic screen to discover ...
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Original Article Clinicopathological classification and traditional prognostic indicators of breast cancer
... of luminal A, luminal B, HER2-positive luminal B, triple negative and non-luminal HER2- positive subtypes were: ...The luminal A subtype is significantly associated with ...
6
Breast cancer in Iraq is associated with a unimodally distributed predominance of luminal type B over luminal type A surrogates from young to old age
... of luminal B breast cancers in developing countries may be a reflection of the younger populations and the relatively small proportions of aging women exposed to premenopausal ...of luminal A ...of ...
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Gene modules associated with breast cancer distant metastasis- free survival in the PAM50 molecular subtypes
... for luminal B BC patients. For luminal A subtypes, PTEN loss modules and E2F3 activation are associated with poor DMFS, suggesting that these patients are likely to benefit from poly (ADP-ribose) ...
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