Lung carcinogenesis
Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema
... (2) lung carcinogenesis mice induced by urethane (U group), and (3) lung emphysema-carcinogenesis mice induced by elastase and urethane (E–U ...group). Lung carcinogenesis was ...
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MicroRNA-365 promotes lung carcinogenesis by downregulating the USP33/SLIT2/ROBO1 signalling pathway
... in lung adenocarcinoma and lung cancer cell ...on lung cancer cell proliferation, migra- tion, and invasion were also explored in ...ing lung carcinogenesis via the downregulation of ...
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Original Article Expression of HDAC9 in lung cancer – potential role in lung carcinogenesis
... carcinogenesis [7-10]. Aberrant HDAC9 expres- sion has been observed in several types of can- cers including medulloblastoma [11], acute lymphoblastic leukemia [12], and cervical carci- noma [13]. In our ...
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Antioxidant activity of berberine on benzo (A) pyrene induced experimental lung carcinogenesis in mice
... induced lung carcinogenesis that is measured by over production of 8-hydroxyguanine in lung and the liver of a B(a)P administrated ...in lung and liver of cancer bearing ...
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Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis
... man lung cells ...of lung cancer and the downregulation of PPARγ activity contributes to lung cancer progression ...prevent lung tumorigenesis caused by the major smoking carcinogen ...
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Identification of a long non-coding RNA NR_026689 associated with lung carcinogenesis induced by NNK
... rat lung carcinogenesis induced by NNK, we selected 3 pairs of rat lung tumor samples and matched normal lung tissues and 2 blood samples from the control and NNK treatment group in the 95th ...
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In Vivo Potential Effects of Adenovirus Type 5 E1A and E1B on Lung Carcinogenesis and Lymphoproliferative Inflammation
... stimulating lung carcinogenesis requires further clinical inves- tigations, although other previous studies failed to detect the adenoviral genomes in human lung carcinomas and adenocar- cinomas ...
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Anti-Cancer efficacy of Umbelliferone against Benzo(a)pyrene-induced Lung Carcinogenesis in Swiss Albino Mice
... commonly present in the daily human diet. A variety of compounds have undergone clinical trials against lung cancer based on this strategy [7]. Flavanoids are naturally occurring molecules abundant in fruits, ...
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Requirement for MUC5AC in KRAS-dependent lung carcinogenesis
... In lung ADC cell lines in vitro, MUC5AC gene expression is controlled by EGFR- and HIF-1–depen- dent pathways (45), both of which are important factors in lung ...in lung ADCs (20, ...in lung ...
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Role of retinoic receptors in lung carcinogenesis
... to lung cancer [18,20], decreased RAR β 2 mRNA expression has been demonstrated in a variety of solid tumors including head and neck [21]and breast carcinomas ...primary lung cancer and that in distant ...
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Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis
... cell lung cancer A549 cells reduced colony formation, PGE 2 synthesis and ERK phosphorylation compared to that of vector control ...K-ras–induced lung tumorigenesis by reducing tumor cell proliferation, ...
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Original Article The Effect of Different Doses of Cigarette Smoke in a Mouse Lung Tumor Model
... Abstract: Few studies have used Balb/c mice as an animal model for lung carcinogenesis. In this study, we investigated the effect of different doses of cigarette smoking in the urethane-induced Balb/c mouse ...
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Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice
... for lung tumor size, which was not affected by the induction of acute or chronic allergic air- way inflammation (Figure ...of lung neoplastic lesions between early (AAH) and more progressed (adenoma, ...
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<p>Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis</p>
... with lung cancer present with advanced-stage disease when diagnosed, and even in patients with early-stage resectable or locally advanced disease receiving de fi nitive chemo- or radiation therapy, up to 90% of ...
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Original Article Squamous cell carcinoma of the lung: gene expression and network analysis during carcinogenesis
... growth in small cell lung cancer cells. Thus, it was proposed to be a novel candidate target for therapy [37, 38]; NMRAL2P-This is a pseu- dogene. It has been identified as a direct tran- scriptional target of ...
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Esophageal Carcinogenesis
... b-1 Normal esophageal squamous epithelium; b-2 Squamous cell hyperplasia; b-3 Mild dysplasia; b-4 moderate dysplasia; b-5 Severe dysplasia; b-6 Squamous cell papilloma; b-7 Squamous cell[r] ...
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Hypermutability in Carcinogenesis
... If one assumes that expected frequency of a newly arising mutation in a tumor might be, considering that a sufficient number among the tumors with multiple p53 mutations, silent.. mutati[r] ...
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NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration, and Chemoresistance
... Since tobacco is a well characterized risk factor for oral cancer, we investigated whether NGAL is regulated by tobacco carcinogens. The main carcinogens characterized from tobacco smoke include benzo[a]pyrene, ...
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Autogenous Immunity to Endogenous RNA Tumor Virus: Differential Reactivities of Immunoglobulins M and G to Virus Envelope Antigens
... AARONSON Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, and Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryla[r] ...
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... Inflammatory responses are critical cellular processes associated with many physiological and pathological changes in the body [1]. Thus, many factors and agents are involved in inflammatory responses. In cancers, ...
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