Lung epithelial
mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells
... in lung epithelial ...human lung fibroblasts to myofibroblasts ...of epithelial marker expression in A549 cells and concur- rent gains in mesenchymal ...an epithelial to ...
11
Pneumocystis carinii inhibits cyclin dependent kinase activity in lung epithelial cells
... prolonged lung repair in a subset of patients with ...this lung injury are not fully known, but likely incorporate both direct effects from the organisms as well as the adverse effects of neutrophilic ...
9
Original Article Paraquat induces acute respiratory distress syndrome by promoting the lung epithelial-mesenchymal transition
... promoted lung epithelial-mesenchymal transition by ...human lung epithelial cell lines HPAEpiC after treated with saline and paraquat for 24 ...
9
Taurine modulation of hypochlorous acid induced lung epithelial cell injury in vitro Role of anion transport
... Airway secretions of cystic fibrosis patients were found to contain high concentrations of taurine, which decreased with antibiotic therapy during acute respiratory exacerbations. Taurine, in a 1:1 molar ratio with ...
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β Catenin maintains lung epithelial progenitors after lung specification
... human lung progenitors from hESC Human lung progenitors were derived from Rockefeller University Embryonic Stem Cell Line 2 [RUES2, NIH Registration number 0013, a gift from Dr Ali Brivanlou (Rockefeller ...
13
The interaction of Francisella tularensis with lung epithelial cells
... post-inoculation, indicating that the majority of intracellular bacteria were no longer contained within intact endocytic vacuoles. It should be noted that once the vacuolar membrane begins to degrade bacteria are ...
170
Cotton dust mediated lung epithelial injury
... tetrahydroxy-flavan 3,4-diol (THF), a tannin in cotton dust and bract, caused substantial cell damage. Field-dried bract extract and THF also produced dose-dependent inhibition of pneumocyte protein synthesis. Endotoxin ...
11
CCR10+ epithelial cells from idiopathic pulmonary fibrosis lungs drive remodeling
... cultured epithelial cells. Further, given the expansion of airway epithelial cells in IPF lungs (14–16), we also hypothesized that cytokines abundantly expressed in IPF lung tissues may promote the ...
22
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators
... the lung epithelial surface, comprising up to 9% of the total cells recovered by BAL from normal in- dividuals (47, ...the epithelial lining fluid is provided by studies which demonstrate expression ...
11
Lung development in laminin γ2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation
... saccular size. Measurement of chord length confirmed the increase in the Lamc2-/- (25 µm) as compared to litter- mate control (20 µm) saccule size, however this difference was not statistically significant (p < 0.07, ...
12
Intersections of lung progenitor cells, lung disease and lung cancer
... between epithelial progenitors, endothelial cells and mesenchymal cells in the ...distal lung epithelial cells require stromal cell inputs ( perhaps secretory and structural in nature) to thrive in ...
6
Original Article NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of Acute Respiratory Distress Syndrome
... in epithelial cells concomitantly to cell death and associated to STAT3 signaling in the exudative phase of ...NOX1-dependent epithelial cell death was confirmed by using a lung epithelial ...
15
<p>EFEMP2 Suppresses the Invasion of Lung Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition (EMT) and Down-Regulating MMPs</p>
... of lung tissues showed that the high expression rate of EFEMP2 in normal lung tissues was higher than that in lung cancer tissues, and EFEMP2 was highly expressed in well-differentiated carcinoma in ...
22
Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
... mouse lung explants and increase surfactant protein expression in mouse ESC-derived lung progenitors [7, ...of lung and airways cells but was biased toward distal ...(nascent lung bud orga- ...
6
Shared epithelial pathways to lung repair and disease
... Chronic lung diseases, such as COPD and idiopathic pulmonary fibrosis (IPF) are generally accepted to arise from chronic epithelial injury and incomplete or aberrant repair processes ...contrast, ...
6
Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
... All animal studies were approved by the Institutional Animal Care and Use Committee at the Yale University School of Medicine. The TGFβ1TG mice were generated as previously described [3,16], and express TGFβ1 with ...
12
Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model
... basal epithelial cell line; BEAS-2B: human normal lung epithelial cell line; NSCLC: non-small cell lung cancer; IFN: interferon; XAF1: XIAP associated factor-1; OAS: 2,5-oli- goadenylate ...
10
Induction of Alternatively Activated Macrophages Enhances Pathogenesis during Severe Acute Respiratory Syndrome Coronavirus Infection
... severe lung pa- thology that persisted throughout the course of ...showed lung pathology similar to that seen in WT ...the lung, but most notably displayed cuffing around large airways and blood ...
16
<p>Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis</p>
... It was found that some keratins have regulatory func- tions, including cell movement, cell size, proliferation, apoptosis, and cell signal transduction. 12–15 In the early stage of human skin injury, expression levels of ...
13
Ultrastructural and protein analysis of surfactant in the Australian lungfish Neoceratodus forsteri: evidence for conservation of composition for 300 million years
... The epithelial lining of these supporting structures comprises abundant capillaries interspersed with cells resembling alveolar type II cells ...the epithelial lining and appeared between each ...
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