Lung fibroblasts
Original Article Effect of IL-13Rα2 on TGF-β expression and collagen synthesizing induced by IL-13 in human lung fibroblasts HFL-1
... pulmonary fibroblasts, we treated human lung fibroblasts HFL-1 cells with 0, 10, 20, 50, and 100 ng/ml of IL-13 and measured the expression of IL-13Rα1, IL-13Rα2, TGF-β and collagen I with qRT-PCR ...
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The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts
... chronic lung diseases including idiopathic pulmonary fibrosis ...fatal lung disease characterized by persistent fibrotic fibroblasts in response to type I collagen-rich extracellular ...human ...
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Periostin plays a critical role in the cell cycle in lung fibroblasts
... the lung tissue of IPF patients ...of lung fibroblasts, but not of airway epithelial cells [8–10, 13], suggesting that fibro- blasts are main sources of periostin in ...
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Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts
... distally-derived fibroblasts from se- vere COPD patients demonstrated a more contractile phenotype in this study, probably due to enhanced ROCK1 activity [18], than fibroblasts from control sub- jects, and ...
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BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas
... for lung development and organogenesis ...in lung fibroblasts in response to stimulation with BMP2, BMP4, BMP7 and their antagonists Gremlin and ...
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Hepatocyte growth factor produced in lung fibroblasts enhances non-small cell lung cancer cell survival and tumor progression
... fetal lung fibroblasts (HFL1, MRC5 and IMR90 cells) were purchased from the American Type Culture Collection (Rockville, ...MD). Fibroblasts were cultured in DMEM supplemented with 10% FBS; cells ...
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Relaxin induces an extracellular matrix degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
... human lung fibroblasts in vitro, and to inhibit lung fibrosis in a bleomycin-induced murine ...human lung fibroblasts by up to 45% in a dose-dependent ...by lung hydroxyproline ...
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Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase 2
... In this study, we compared lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis F-IPF and from patients undergoing resectional surgery for lung cancer F-nl with res[r] ...
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis
... and fibroblasts in IPF lungs (8, ...senescent fibroblasts secrete PDGF receptor ligands, supporting their role in fibrosis ...of lung injury ...senescent fibroblasts, raising the possibility ...
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Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts
... normal lung, obscur- ing the demarcation between normal and abnormal phe- notypes, when cell lines are isolated using standard techniques ...in fibroblasts derived from fibrotic lungs ...the ...
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C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
... human lung fibroblasts via the inhibitory effect of CNP on TGF-β-stimulated phosphorylation of ...in lung fibro- ...human lung fibroblasts of patients with or without ...acute ...
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Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts
... The Janus kinase (JAK)-STAT6 pathway is key to IL- 13 signaling [24]. We confirmed that clarithromycin suppressed the phosphorylation of STAT6, but the abil- ity of clarithromycin to attenuate periostin production may ...
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Leflunomide inhibits the apoptosis of human embryonic lung fibroblasts infected by human cytomegalovirus
... Leflunomide (LEF) is an immunosuppressive drug used clinically for the treatment of transplantation patients. Interestingly, besides its immunosuppressive activities, LEF can interfere with the replication of many ...
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Lung fibroblasts from patients with emphysema show markers of senescence in vitro
... The upregulation of IGFBP-3 and -rP1 can be taken as fur- ther evidence for a senescent phenotype in emphysema. As these proteins interact with mitogenic compounds such as insulin-like growth factor I and II (IGF-I, II) ...
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PubMedCentral-PMC4867233.pdf
... in lung epithelial cells and fibroblasts primarily used exogenous pre-miRNA transfected into ...in lung biology and relevant derivative cell ...Calu3 lung adenocarcinoma cells, 16HBE14o-, ...
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Human endothelial cell lymphocyte interaction Endothelial cells function as accessory cells necessary for mitogen induced human T lymphocyte activation in vitro
... evidenced by the finding that human foreskin fibroblasts, lung fibroblasts, and HeLa cells were unable to restore responsiveness to monocyte-depleted T cells. These observations indicate that ...
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Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
... Next, we investigated the effects of nintedanib on the fibrocyte-induced proliferation of lung fibroblasts. Fibro- blast proliferation induced by the culture supernatant of fibrocytes was inhibited by ...
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PDGF-Rα gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts
... mouse lung fibroblasts from PDGF-Rα-GFP mice aged P4 (A - C) and P12 (E - ...G). Fibroblasts were stained for ki67 (C and G) or IgG control (B and F), followed by Alexa-Fluor 647-conjugated secondary ...
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Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
... quiescent fibroblasts to cancer-associated fibroblasts through direct tumor–stromal interactions ...in lung fibrosis [23], but also in other types of tissue fibrosis including renal fibrosis [31], ...
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Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes
... Acetylcholine (ACh) in the culture supernatants was an- alyzed by liquid chromatography tandem-mass spec- trometry (LC-MS/MS). Sub-confluent lung fibroblasts on a 6-well plate were deprived of serum for 24 ...
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