Lupus anticoagulant (LA)
Anti beta2 glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant like activity enhance the beta2GPI binding to phospholipids
... exert lupus anticoagulant (LA) activity and perturb the function of vascular endothelial ...This anticoagulant activity was abrogated in the presence of an excess amount of phospholipids, thus ...
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Overt increase in lupus anticoagulant level in HIV patients co-infected with pulmonary Mycobacterium tuberculosis infection: A prospective cohort study
... of LA is known to relate to increase tendency for thrombophilia [5, 10, 14]; while paradoxically prolongs phospholipid dependent coagulation markers in vitro [20, ...21]. Lupus anticoagulant is now ...
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In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
... Despite an increasing interest in membrane-shed MPs, little is known about MPs of endothelial origin. In vitro experiments have established that complement proteins C5b-9 induce vesiculation of the endothelial plasma ...
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Localization of the apoptosis inducing activity of lupus anticoagulant in an annexin V binding antibody subset
... Lupus anticoagulant (LAC) is associated with arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss. We have reported previously that plasma with LAC ac- tivity induces apoptosis in ...
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Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
... a lupus anticoagulant and factor VIII inhibitor without a prior history of thrombosis or ...a lupus anticoagulant but this did not explain the clinical ...
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Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2 glycoprotein I
... similar anticoagulant properties, the relationship of beta 2GPI to lupus anticoagulant activity was ...and lupus anticoagulant activity in the presence and absence of beta ...no ...
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Thrombin generation as marker to estimate thrombosis risk in patients with abnormal test results in lupus anticoagulant routine diagnostics
... the LA testing program of the laboratory from January to December 2009 (Figure ...for la- boratory investigation were previous thrombosis, evalu- ation of prolonged, activated partial thromboplastin time ...
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Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant
... for LA with and without a his- tory of thrombosis and included subgroups of patients with other potentially relevant factors, such as concomi- tant autoimmune rheumatic ...in LA-positive pa- ...in ...
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Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant
... anticoagulant). HLA-DQw7 (DQB1*0301), linked to HLA-DR5 and -DR4 haplotypes, occurred in 70% and was significantly increased compared to 139 race-matched normal controls (P = 0.002, P corrected [pc] = 0.05, odds ...
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Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor
... The effect of using three different sourcesof tissue factor recombinant,human brain and rabbit brain thromboplastinsin the TFPI assay was examined.. Of most significance was the apparent[r] ...
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Monoclonal immunoglobulin M lambda coagulation inhibitor with phospholipid specificity Mechanism of a lupus anticoagulant
... Substitution of washed platelets for phospholipid led to normalization of patient coagulation tests and corrected all abnormalities produced in normal plasma by patient IgM.. Furthermore[r] ...
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Profile of patients with Thrombosis evaluated in a Tertiary Care Center.
... the LA is not directed against a specific factor, but to phospholipids 5,16,30,31,50 ...between lupus inhibitors and other inhibitors of clotting ...of lupus anticoagulant is highly dependant ...
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Final Diagnosis of Pediatric Patients with Prolonged in Activated Partial Thromboplastin Time Preoperative Study
... the lupus anticoagulant ...the lupus anticoagulant is not yet exactly known, but to be considered transitory, not related with autoimmune diseases as the antiphospholipid syndrome, it must be ...
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LA and aCL in an unselected popula- tion of children with idiopathic cerebral ischemia and to compare the clinical and radiological features observed in aPL-positive and aPL-negative patients. PATIENTS AND METHODS
... To investigate the prevalence of aPLs, de- tected as lupus anticoagulant (LA) or anticardiolipin an- tibody (aCL), in a group of unselected children with idiopathic cerebral ischemia.. D[r] ...
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Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay
... include lupus anticoagulant, a functional coagulation assay, and anticardiolipin and anti-β2-glycoprotein-I antibodies, generally detected by solid phase enzyme-linked immunosorbent ...assay, Lupus ...
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Case report: primary osteonecrosis associated with thrombophilia-hypofibrinolysis and worsened by testosterone therapy
... (lupus anticoagulant, high anticardiolipin [ACLA] antibody IgM), and hypofibrinolysis (4G4G homozygos- ity for the plasminogen activator inhibitor −1 mutation) with hip and jaw ON, and the interaction of TT ...
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Acquired activated protein C resistance and thrombosis in multiple myeloma patients
... lant was important in this case. Patients with APCR were negative for lupus anticoagulant. We found only one patient with genetic PCR who did not develop thrombo- sis. People with the APC-R phenotype ...
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On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies
... C anticoagulant activity but has little influence on prothrombin ...C anticoagulant pathway by lupus anticoagulants and/or antiphospholipid ...augments lupus anticoagulant ...with ...
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Anticardiolipin antibodies in unexplained pregnancy loss
... Antiphospholipid Syndrome may be either primary if other features of connective tissue disease are absent or secondary to established connective tissue diseases such as systematic lupus erythematosus. It is ...
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Current Update on Recurrent Pregnancy Loss.
... Routine Investigations after two consecutive miscarriages include basic blood tests like Hemogram, HBA1C, Thyroid Stimulating Hormone, Prolactin (in presence of symptoms), transvaginal ultrasonography (USG-TVS), (3D) ...
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