Lymphoblastoid cell lines
![Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.
... The results indicate that BW B759U, in contrast to ACV, is preferentially phosphorylated in human lymphoblastoid cell lines infected with EBV and that the triphosphate of BW B759U persis[r] ...
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A Study of Using Lymphoblastoid Cell Lines in Pharmacogenomics and Drug Family Clustering.
... cancer cell lines to identify potential markers for patient drug ...tissues. Lymphoblastoid cell lines (LCLs) are a relatively new tool in gene mapping and are often used in conjunction ...
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Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp).
... During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six EBV nuclear antigens (EBNAs) are expressed from one of two promoters, Cp and Wp, whose activities are mutually exclusive. Upon infection, Wp ...
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Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair
... Apart from this, LCLs have also expanded their niche as a tool for a variety of DNA damage/repair studies. An excellent utilization of LCLs for such kind of research was done by Motykiewicz et al., where DNA repair ...
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Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines
... EBV-transformed lymphoblastoid cell lines and therefore it should be noted that the differential gene expression being ascribed to drug treatment are on the background of an EBV transformation, which ...
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Complementation analysis of measles virus mutants isolated from persistently infected lymphoblastoid cell lines.
... 33, No.3 Complementation Analysis of Measles Virus Mutants Isolated from Persistently Infected Lymphoblastoid Cell Lines GRACE JU,1 MICHAEL BIRRER,1 STEPHEN UDEM,23 AND BARRY R.. BLOOM`*[r] ...
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Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines
... immortal lymphoblastoid cell lines (LCLs), providing a model for EBV-mediated ...mediate cell-cell adhe- ...a cell adhesion molecule on primary B cells that may play a role in ...
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Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines
... human lymphoblastoid cell lines were examined for the presence of the EAC¢ and EA ...the cell lines studied could be classified as B lymphocytes by the presence of the EAC¢ receptor and ...
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oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.
... During Epstein-Barr virus latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities are mutually exclusive. Upon infection, Wp is ...
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Intracellular accumulation of Praziquantel in T lymphoblastoid cell lines, CEM (parental) and CEMvbl(P-gp-overexpressing)
... sterile-filtered, cell culture tested); Roswell Park Memorial Institute medium [RPMI] ...T-lymphoblastoid cell lines, CEM and CEM VBL cells were gifts from ...
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Transcript Isoform Variation Associated with Cytosine Modification in Human Lymphoblastoid Cell Lines
... ABSTRACT Cytosine modification on DNA is variable among individuals, which could correlate with gene expression variation. The effect of cytosine modification on interindividual transcript isoform variation (TIV), however, ...
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Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines
... Transcriptomic analysis is a powerful tool for charac- terizing susceptibility and resistance to drugs [17,18]. This approach can uncover previously unrecognized mechanisms of drug response and provides information on ...
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Epstein-Barr Virus Lytic Infection Is Required for Efficient Production of the Angiogenesis Factor Vascular Endothelial Growth Factor in Lymphoblastoid Cell Lines
... early-passage lymphoblastoid cell lines (LCLs) derived with either Z-KO or R-KO EBV (Z-KO or R-KO LCLs, respectively) were impaired for growth in SCID mice in comparison to LCLs infected with WT EBV ...
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Patient derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery
... Five lymphoblastoid cell lines derived from mitochondrial disease patients harboring point mutations in mtND1, mtND4, or mtATP6 were characterized in two high throughput assays assessing ...
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Limitations of lymphoblastoid cell lines for functional analysis of SNPs
... chose lymphoblastoid cell lines harboring AA/ GA/GG genotype and acquired two for each genotype from National Human Genome Research Institute ...the cell lines with the previous ...
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Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines
... Patient-specific induced pluripotent stem cells (iPSCs) facilitate understanding of the etiology of diseases, discovery of new drugs and development of novel therapeutic interventions. A frequently used starting source ...
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Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
... of cell types, have been used to study panic disorder, nicotine dependence, post-traumatic stress dis- order [15], schizophrenia [3,6,10,18], bipolar disorder [10], Huntington disease [11], epilepsy [12], Tourette ...
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Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell lines.
... ACV nucleotides formed in Vero, HSVinfected Vero, P3HR-1, and HSV-infected P3HR-1 cells ACV phosphorylated derivatives pmol per l0o cells Cell type Monophosphate Cell type Monophosphate [r] ...
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Characterization of reticuloendotheliosis virus-transformed avian T-lymphoblastoid cell lines infected with Marek's disease virus.
... Interestingly, our results showed that transfected MDV genes from the BamHI-A fragment Us and IRS regions of the cloned BamHI library of the MDV genome 14 may be able to transactivate tr[r] ...
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Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines
... whereas a 50-fold reduction in transformation efficiency and reduced growth from low starting cell density were observed with Akata EBV. This might be a consequence of a high intrinsic transforming ability of the ...
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