lymphokine-activated killer
Lymphokine-activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites
... (iDC), Lymphokine-activated killer (LAK) cells and LAKDC cocultures were tested as potential carriers for reovirus for tumor cell killing and immune cell ...
11
Involvement of cyclic adenosine monophosphate in the interleukin 4 inhibitory effect on interleukin 2 induced lymphokine activated killer generation
... In previous studies, IL-4 has been reported to interfere with IL-2-driven generation of lymphokine-activated killer (LAK) activity. In this investigation, we have demonstrated that IL-4 inhibited the ...
6
Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine activated killer cells
... In the absence of antigenic or mitogenic stimulation, certain peripheral blood lymphocytes exhibit proliferative and lymphokine-activated killer (LAK) cell activities when cultured with recombinant ...
9
Celecoxib increases lung cancer cell lysis by lymphokine- activated killer cells via upregulation of ICAM-1
... The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, ...
15
Natural Killer Cell Immunodeficiency in Siblings: Defective Killing in the Absence of Natural Killer Cytotoxic Factor Activity in Natural Killer and Lymphokine-Activated Killer Cytotoxicities
... Natural killer cells play important roles in the defense against tumor growth and viral infections.’ In the cytolytic event, natural killer cells first nec- ognize and bind to a target c[r] ...
10
Antiviral effect of lymphokine-activated killer cells: characterization of effector cells mediating prophylaxis.
... IFN protected targets from polyinosinic acid-polycytidylic acid-induced activated NK cells but enhanced their susceptibility to lysis by allospecific DISCUSSION The adoptive transfer stu[r] ...
7
Lymphokine-activated killer cell susceptibility and adhesion molecule expression of multidrug resistant breast carcinoma
... phokine-activated killer (LAK) cell sensitivity of the multidrug resistant (MDR) P-gp(+) small cell lung carci- noma line H69/LX4, but not the multidrug resistant-asso- ciated protein(+), P-gp(-) and ...
13
Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.
... In normal adult mice, reovirus 1/L enters the host through M cells overlying the Peyer’s patches (27) and causes localized, subclinical gastroenteritis (20). This infection results in pro- duction of virus-specific ...
5
Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS.
... Regression analysis also showed that addition of CD4+ PBL numbers increased the predictive power of CD56+ LAK cells in explaining U-937 and K-562 target cell lysis per unit blood volume,[r] ...
7
Immune cell therapy for hepatocellular carcinoma
... and lymphokine- activated killer (LAK) and cytokine-induced killer (CIK) cell ...administered activated lymphocytes had a 5-year recurrence-free survival rate of 38% compared with 22% ...
11
High dose interleukin-2 (Aldesleukin) - expert consensus on best management practices-2014
... LAK: Lymphokine activated killer; LVEF: Left ventricular ejection fraction; TNF- α : Tumor Necrosis Factor Alpha; BUN: Blood urea nitrogen; NCI: National Cancer Institute; IU: International units; ...
23
The Natural Killer Cell: A Historical Perspective and the Use of Supplements to Enhance NKC Activity
... of killer cells in vivo, be- cause the optimal concentration of LEN for the induction of killer cells in vitro was equivalent to the plasma con- centration obtained after clinical doses of this agent ...
32
Role of human natural killer cells in health and disease.
... NK cells constitutively express IL-2RP (p75) and, in the presence of IL-2, develop into lymphokine-activated killer (LAK) cells capable of killing a broad array of fresh or cultured tumo[r] ...
9
Killing of intracellular Leishmania donovani by lymphokine stimulated human mononuclear phagocytes Evidence that interferon gamma is the activating lymphokine
... We have found that the crude lymphokines, which prime the human monocyte-derived macrophage to generate H2O2 and exert microbicidal activity against intracellular Leishmania donovani, ar[r] ...
6
Dendritic Polymers for Theranostics
... Biotherapy utilize biological agents such as nucleic acids (DNA, RNA), proteins or peptides (eg. monoclonal antibodies, tumor antigens, cytokines), cells (eg. activated killer cells, [r] ...
18
Targeting prostate cancer stem-like cells by an immunotherapeutic platform based on immunogenic peptide-sensitized dendritic cells-cytokine-induced killer cells
... cells activated by a recombin- ant prostatic acid phosphatase-granulocyte-macrophage colony-stimulating factor (PAP-GM-CSF) into patients, is the only FDA-approved immunotherapy for advanced mCRPC ...
15
Case Report Aggressive natural killer cell leukemia mimicking interstitial lung diseases with the activation of the mitogen-activated protein kinase pathway
... Abstract: Aggressive natural killer (NK) cell leukemia (ANKL) is a rare form of leukemia with an aggressive clinical course. It commonly involves the peripheral blood, bone marrow, liver, and spleen but rarely ...
7
Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection.
... of activated hepatocytes (20), other features of the immune response to MCMV or of the infection itself may be sufficient for such TNF-independent hepatocyte death and liver ...
11
Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells
... Purified NK cells from C57BL/KaLwRij mice were acti- vated in vitro, stained with CFSE and 5 × 10 5 cells were i.v. transferred into mice 3 weeks after tumor injection. To define the role of Cxcr3 deficiency in NK ...
16
Pulmonary manifestations in Behçet disease: impaired natural killer cells activity
... Natural killer (NK) cells not only exert cell-mediated cytotoxicity against tumour or infected cells, but also regulate other immune cells functions by secretion of cytokines and ...
8