lymphokine activated killer cells
Antiviral effect of lymphokine-activated killer cells: characterization of effector cells mediating prophylaxis.
... IFN protected targets from polyinosinic acid-polycytidylic acid-induced activated NK cells but enhanced their susceptibility to lysis by allospecific DISCUSSION The adoptive transfer stu[r] ...
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Celecoxib increases lung cancer cell lysis by lymphokine- activated killer cells via upregulation of ICAM-1
... metastatic cells derived from a lung cancer patient, the present study investigates the impact of celecoxib on the expression of intercellular adhesion molecule 1 (ICAM-1) and cancer cell lysis by ...
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Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine activated killer cells
... CD16+ cells, which display distinctive Fc receptors for IgG ...natural killer cell ...T cells to proliferate. However, at least a small subset of blood T cells can be activated by IL-2 ...
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Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.
... pivotal in lethal disease. Here, the inflammatory response, through the release of mediators such as tumor necrosis factor or leukotrienes, would cause hepatocyte damage in infected mice. The third proposes that liver ...
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Lymphokine-activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites
... using cells which internalize OV has been shown to be an effec- tive mechanism to deliver virus to tumor in the presence of NAb, predominantly in murine models, using carrier cells as “Trojan horses,” which ...
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Lymphokine-activated killer cell susceptibility and adhesion molecule expression of multidrug resistant breast carcinoma
... carcinoma cells and increased metastases to lymph nodes was described ...tumor cells to LAK ...carcinoma cells in tissue culture ...plasma cells in tissue culture [25]. These cells ...
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Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlate of progression to AIDS.
... Regression analysis also showed that addition of CD4+ PBL numbers increased the predictive power of CD56+ LAK cells in explaining U-937 and K-562 target cell lysis per unit blood volume,[r] ...
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The Natural Killer Cell: A Historical Perspective and the Use of Supplements to Enhance NKC Activity
... of killer cells in vivo, be- cause the optimal concentration of LEN for the induction of killer cells in vitro was equivalent to the plasma con- centration obtained after clinical doses of ...
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Natural Killer Cell Immunodeficiency in Siblings: Defective Killing in the Absence of Natural Killer Cytotoxic Factor Activity in Natural Killer and Lymphokine-Activated Killer Cytotoxicities
... Natural killer cells play important roles in the defense against tumor growth and viral infections.’ In the cytolytic event, natural killer cells first nec- ognize and bind to a target c[r] ...
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Role of human natural killer cells in health and disease.
... NK cells constitutively express IL-2RP (p75) and, in the presence of IL-2, develop into lymphokine-activated killer (LAK) cells capable of killing a broad array of fresh or cultured tumo[r] ...
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Enhancement of natural killer function through activation of the T11 E rosette receptor
... the cells responsible for lymphokine-activated killing are likely to be the same population capable of spontaneous or natural killing before activation in ...
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Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
... for IL-8 production in NK cells. In fact, IL-8 production was also remarkably high in monocyte-depleted PBMC cultures from SLE patients (Additional file 15) but, due to a shortage of patient material, the effects ...
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Natural killer cells: role in local tumor growth and metastasis
... natural killer (NK) cells came from their natural ability to kill tumor cells in ...NK cells in host immune response against cancer and in therapy-induced antitumor ...tumor cells by NK ...
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The role of nonspecific cytotoxic cells and cytokine production in the pathogenesis of human intestinal diseases
... General Introduction 1.1 Characteristics of natural killer and killer cells 1 1.2 Killer cells and antibody-dependent cellular cytotoxicity 6 1.3 The origin and differentiation of natura[r] ...
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Pulmonary manifestations in Behçet disease: impaired natural killer cells activity
... target cells were stained with FITC-conjugated anti-CD45 mAb at 4°C for 20 mi- nutes, washed once in phosphate buffered saline (PBS), resuspended in ...K562 cells were determined by flow ...K562 ...
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Targeting prostate cancer stem-like cells by an immunotherapeutic platform based on immunogenic peptide-sensitized dendritic cells-cytokine-induced killer cells
... Based on the common self-renewal and anchorage- independent growth capacities of CSCs derived from dif- ferent cancers, we have previously established an agar- based non-adherent 3D-culture method for isolation and ...
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Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD)
... these cells possess not only inhibitory receptors but also activating receptors and killing ability is determined by a balance of signals from both types of ...those activated cells (data not ...
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Adenovirus E1A gene induction of susceptibility to lysis by natural killer cells and activated macrophages in infected rodent cells.
... To justify using both Ad2 and AdS mutant viruses in studies of viral genetic regulation of induction of cytolytic susceptibility in infected rodent cells, we first compared the effects o[r] ...
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Natural killer cells and natural killer T cells in Lyme arthritis
... NK cells were found in SF, the inflammatory site, compared with PB (P ...of cells expressed the activation receptor NKG2D and the chaperone CD94, a low percentage expressed inhibitory killer ...
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Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells
... NK cells from C57BL/KaLwRij mice were acti- vated in vitro, stained with CFSE and 5 × 10 5 cells were ...NK cells were purified from spleen of C57BL/6j WT and Cxcr3 −/− mice, stimulated in vitro and ...
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