Lynch Syndrome (LS)
Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome
... of Lynch Syndrome (LS) in young onset colorectal cancer (CRC) patients and the results were extremely variable ...for LS. The primary aim of our study was to evaluate the prevalence of ...
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Single-center study of Lynch syndrome screening in colorectal polyps
... Lynch syndrome (LS) is the most common disease that causes hereditary colorectal cancer syndrome, account- ing for approximately 2 – 5% of all colorectal cancers [1], caused by autosomal ...
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Patients educating health care providers on Lynch syndrome
... trust of provider’s recommendations. Participants (n=32) often mentioned a provider’s knowledge regarding LS. One participant mentioned she would want the following traits in her provider in order to gain their ...
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Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
... in LS, but rather through a pathway without a visible precursor ...in LS could be prevented by removal of macroscopically visible precursor lesions was not confirmed, even with more frequent surveillance ...
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N LyST: a simple and rapid screening test for Lynch Syndrome
... Lynch Syndrome (LS) arises as a consequence of germline mutation in one of four DNA mismatch repair (MMR) genes ...in LS therefore usually show both loss of expression of at least one of the ...
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Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome
... Background: Lynch syndrome, the most frequent form of hereditary colorectal cancer and involves mutations in mismatch repair ...the LS phenotype in 3 of 4 cases in the ...the LS phenotype in 1 ...
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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
... in Lynch Syndrome (LS), whereas more recent clinical guidelines suggest colonoscopy at least once every 2 years, begin- ning between 20 and 25 years of age ...Prospective Lynch Syndrome ...
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Cancer Risks for PMS2-Associated Lynch Syndrome
... To calculate HRs, we used a likelihood-based approach in which age- speci fi c incidence for PMS2 mutation carriers was divided by that for noncarriers. Incidence rates for noncarriers were assumed to be the same as age-, ...
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Malignant phyllodes tumor in Lynch syndrome: a case report
... Although no specific changes in current screening or monitoring guidelines for patients with Lynch syndrome need to be made, it is evident that these hereditary syn- dromes may harbor propensity for more ...
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PMS2-associated Lynch syndrome : the odd one out
... Another limitation of our study is that only certain cMS targets selected according to their high likelihood of representing functionally relevant drivers of tumorigenesis were analyzed, so that the level of “irrelevant” ...
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Frequent mismatch-repair defects link prostate cancer to Lynch syndrome
... Methods: We used the population-based Danish HNPCC-register to identify all prostate cancers that developed in mutation carriers and in their first-degree relatives from 288 Lynch syndrome families. The ...
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Some aspects of molecular diagnostics in Lynch syndrome
... Lynch syndrome generally results from a mutation carrier state in MSH2 or MLH1 genes. Occasionally, similar clinical and pedigree characteristics may be due to mutations in a variety of other genes, ...
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Sense of coherence and self-concept in Lynch syndrome
... cancer. Lynch syndrome is a multi-cancer syndrome caused by inherited DNA mismatch-repair gene muta- tions that confer particularly high risks for colorectal cancer and gynaecological ...In ...
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Lynch syndrome: barriers to and facilitators of screening and disease management
... of Lynch syndrome (views of screening protocols and timelines to diagnosis, coping approaches to short/long term prognosis, impli- cations for children) and differences between affected and unaffected ...
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Mutation spectrum in South American Lynch syndrome families
... to Lynch syndrome have been identified in 99 families, which corresponds to 37% of the families that fulfilled the Amsterdam criteria and/or Bethesda guide- lines and underwent genetic ...Portuguese ...
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Risk of breast cancer in Lynch syndrome: a systematic review
... in Lynch syndrome described in the previous studies are relatively small compared with the increased risks observed for colorectal and endometrial cancers ...
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Decisions about prophylactic gynecologic surgery: a qualitative study of the experience of female Lynch syndrome mutation carriers
... Women should also be given information about the risks and benefits of hormone replacement therapy (HRT), though evidence suggests they may not be given adequate information in this regard [15]. Of course, clin- ical ...
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Unusual presentation of Lynch Syndrome
... in Lynch Syndrome, due to somatic mutation of the corresponding normal allele, results in the accumulation of DNA replication errors in tumours associated with the ...Many Lynch ...
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Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy
... In LS, the estimated lifetime risk of develop- ing SBC is ...in LS are still ...with LS, it is import- ant to obtain more robust data about SBC prevalence and ...
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Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance:first report from the prospective Lynch syndrome database
... The surveillance guidelines included follow-up aimed at diag- nosis of colorectal adenomas or early CRC and in many centres endometrial cancer and ovarian cancer, as well as cancer aware- ness for all cancers known to be ...
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