Lysine methyltransferase
<p>MicroRNA-769-5p Promotes The Growth Of Glioma Cells By Targeting Lysine Methyltransferase 2A</p>
... These four glioma cell lines (A172, T98, U87 and U251) and a normal human astrocyte (NHA) cell line, which were purchased from the Cell Bank of Shanghai Institute of Cell Biology (Chinese Academy of Medical Science, ...
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Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins
... histone lysine methyltransferase SUV39H2, which is overexpressed in various types of human cancer, plays a critical role in the DNA repair after double strand breakage, and possesses oncogenic ...
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The emerging role of lysine methyltransferase SETD8 in human diseases
... An increasing number of reports on the key role played by lysine methyltransferase SETD8 in physiological and pathological pathways have appeared in literature during the last decade. Many questions are ...
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The role of histone lysine methyltransferase NSD3 in cancer
... Nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax (SET) domain-containing 3 (NSD3) is a well-known histone lysine methyltransferase (HMTase), a member of the NSD protein family. ...
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Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease
... Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and protein function may play a role in ADPKD ...
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A proteomic approach for the identification of novel lysine methyltransferase substrates
... Additional file 2: Figure S2 Reproducibility of protein lysine methyltransferase (PKMT) assays. (A, B) Reproducibility within a fluorescent SET domain-containing SETD6 PKMT experiment (intra-array ...
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The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration
... domain function in EHMT2 could be compensated by EHMT1. On the other hand, the SET domain in EHMT1 is dispensable for mouse viability [16], suggesting EHMT2 could compensate for EHMT1’s methyltransferase activity. ...
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Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells
... H3K9 methyltransferase, Suv39h1, has been shown to direct DNA methylation to major satellite repeats at peri- centric heterochromatin ...H3K9 methyltransferase, has also been found to direct DNA methylation ...
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Extensive lysine methylation in hyperthermophilic crenarchaea : potential implications for protein stability and recombinant enzymes
... bacteria, lysine methylation is relatively rare and is catalysed by sequence-specific lysine methyltransferases that typically have only a single-protein ...unusual lysine methyltransferase ...
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Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
... Histone lysine methyltransferase inhibitors are able to ac- tivate latent HIV-1 proviruses. To further evaluate the contri- butions of epigenetic modifications to the maintenance of HIV-1 latency, we ...
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Post-translational modification-regulated leukocyte adhesion and migration
... the lysine methyltransferase, Ezh2, critically regulates integrin signalling and governs the adhesion dynamics of leukocytes via direct methylation of talin, a key molecule that controls these processes by ...
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Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
... histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic ...
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Adipocyte nuclei captured from VAT and SAT
... H3K9/36me3 lysine-specific demethylases 4A, JMJD2A Jumonji Domain Containing 2A; IHH, Indian Hedgehog Homolog), IKZF1 (IKAROS family zinc finger protein 1; ILF3, interleukin enhancing binding factor 3; KLF2, zinc ...
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Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma
... of methyltransferase-targeted therapy is becoming increasingly important in cancer treatment [51, 52], this research illustrated the potential oncogenic activity of SUV39H2 in lung adenocarcinoma and the possible ...
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Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy
... Abstract: Parkinson’s disease (PD) is a progressive, chronic, neurodegenerative disease characterized by rigidity, tremor, bradykinesia and postural instability secondary to dopaminergic deficit in the nigrostriatal ...
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PRMT6 increases cytoplasmic localization of p21 CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents
... and lysine methyltransferases have frequently been observed in human cancer [38–43], and these enzymes are now considered as emergent targets for anti-cancer drug development [14, 39, ...
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Genomic Adaptations to the Loss of a Conserved Bacterial DNA Methyltransferase
... adenine methyltransferase CcrM are almost universally conserved in the ancient and ecologically very diverse clade of non-Rickettsiales Alphaproteo- bacteria ...
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The Effect of 6-Thioguanine on Proliferation, Viability and Expression of the Genes DNMT 3A, DNMT 3B and HDAC3 in Lymphoid Cancer Cell Line Nalm6
... The amount of histone acetylation is determined by the balance between the activity of the histone acetyltransferase (HAT, which induces the acetylation of histones and reduces their interactions with DNA) and HDAC ...
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L Lysinium trichloroacetate
... The crystal structures of l -lysine monohydrochloride dihy- drate (Wright & Marsh, 1962), l -lysine acetate (Suresh & Vijayan, 1983), dl -lysine pimelic acid (Saraswathi et al., 2003), l ...
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Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program
... of lysine methylation on the histone 3 tail and re-establishment of DNA methylation (Stewart et ...of lysine methylation (Zhang et al., 2015). Trimethylation of lysine 4 (H3K4me3) relates to ...
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