Lysyl Oxidase
Original Article miR-200b is associated with reduced lysyl oxidase in cervical portion of uterosacral ligaments in women with pelvic organ prolapse
... Abstract: Pelvic organ prolapse (POP) refers to a descending or droping of pelvic organs into the vagina due to the tissue degeneration and fragility. miRNAs might be important biomarkers in the pathogenesis of POP. In ...
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Original Article Expression of lysyl oxidase (LOX) in human placental amnion in preterm labor
... that lysyl oxi- dase localized in the human amnions and there was no significant difference in lysyl oxidase levels between TL and ...of lysyl oxidase mRNA in amniotic mesenchymal cells ...
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R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment
... Tumor microenvironmental hypoxia induces hypoxia inducible factor-1α (HIF-1α) overexpression, leading to the release of lysyl oxidase (LOX), which crosslinks collagen at distant sites to facilitate ...
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Original Article Lysyl oxidase G473A promotes migration, invasion and metastasis of ovarian cancer cells through regulating p38/Akt signaling pathways
... Abstract: Objectives: Lysyl oxidase (LOX) always promotes cancer cell metastasis. This study aimed to investigate the influence of LOX G473A on ovarian cancer cells function and the related cell signaling ...
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Original Article Association between expression of lysyl oxidase and prognosis in solid tumor patients: a systematic review and meta-analysis
... Abstract: Background: Recently, lysyl oxidase (LOX) has been frequently reported to be overexpressed in various malignancies and to be involved in tumor invasion and migration. However, a prognostic role of ...
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Original Article Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer
... Abstract: Lysyl oxidase (LOX) has been reported to regulate tumor metastasis and has been found to involve in modification of extracellular matrix (ECM) in the context of ...
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A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans
... Purpose: Lysyl oxidase (LOX) controls the cross-linking and maturation of elastin and collagen fibers. In this study, we investigated the association between LOX gene polymorphisms and intracranial aneurysm ...
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Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder
... exostoses. Lysyl oxidase activity was low in the medium of cultured skin fibroblasts, this abnormality being accompanied by reduced conversion of the newly synthesized collagen into the soluble ...reduced ...
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Original Article Lysyl oxidase single-nucleotide polymorphism (SNP) (G473A) is negatively associated with ovarian cancer prognosis
... Lysyl oxidase (LOX) is a family of extracellular copper-dependent enzymes that catalyzes for- mation of aldehydes from lysine residues in col- lagen and elastin precursors [17], including LOX and four ...
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Relationship between the content of lysyl oxidase dependent cross links in skin collagen, nonenzymatic glycosylation, and long term complications in type I diabetes mellitus
... Many abnormalities in collagen have been reported in insulin-dependent diabetes mellitus, some or all of which have been attributed to increased cross-linking. Although recent work has focused on the role of ...
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Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells
... of lysyl residues with residues that cannot be acetylated (alanine (K to A) or glutamine (K to Q)) represents PPARγ acetylation-defective mutant in and that Pparγ acetylation at the conserved lysine motif serves ...
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A new Bioelectrochemical Method for Detect Nitrite (NO2-) and Hydroxylamine (NH2OH) by Using of Hydroxylamine Oxidase (HAO) and Modified Electrode with Zirconia Nanoparticles
... Enzymes that catalyze redox reactions are called redox enzymes (e.g., Hydroxylamine oxidase in this study). In order to activate the redox enzyme, the electrons have to be transported to or from the enzyme18. ...
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Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation
... the oxidase as determined by superoxide ...cell-free oxidase system arachidonate-dependent but membrane-independent precipitation of the cytosolic ...
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Viral Hijacking of Mitochondrial Lysyl-tRNA Synthetase
... Polyclonal antibodies directed to LysRS recognize the cyto- plasmic and mitochondrial species with similar efficiencies. In the human genome, a single gene (KARS) at position 16q23- q24 encodes LysRS. Two mRNA are ...
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Hormonal regulation of proton secretion in rabbit medullary collecting duct
... indomethacin, lysyl-bradykinin, 8-bromo-cyclic AMP, and forskolin on proton secretion in the major acidifying segment of the distal nephron, the medullary collecting duct from inner stripe of outer ...39%. ...
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Survival and mitochondrial function in septic patients according to mitochondrial DNA haplogroup
... Sepsis is a common, expensive, and frequently fatal condi- tion [1,2]. The physiopathologic mechanisms of sepsis are not well known, but it has been proposed that organ dys- function during sepsis is associated with ...
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Original Article Correlations between single nucleotide polymorphisms in the lysyl oxidase-like 1 gene promoter region and exfoliation syndrome in the Uighur population
... The differences among the LOXL1 gene family members are mainly in the first exon, exhibi- ting changes in length and sequence, and coding of the activation of the N-terminal propeptide enzymes. Mutations in the LOXL1 ...
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Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
... LOX family activity assays were performed with the Amplex Red Monoamine Oxidase Assay Kit (molecular probes, Invitrogen). For the supernatant activity, each cell lines were plated at the same density (750.000 ...
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In Vitro Inhibition of Chick Embryo Lysyl Hydroxylase by Homogentisic Acid: A PROPOSED CONNECTIVE TISSUE DEFECT IN ALKAPTONURIA
... of lysyl hydroxylase and the resulting hydroxylsine-deficient, structurally modified collagen may be clinically significant in the defective connective tissue ...
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
... ysyl oxidase (LOX) is a copper and quinone-cofactor containing amine oxidase that is secreted as an inactive pro-enzyme, and is then cleaved to a mature active form by extracellular metalloproteases such as ...
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