M-CSF
M CSF mediates TNF induced inflammatory osteolysis
... that M-CSF is yet another cytokine playing a central role in inflammatory osteolysis and might be a therapeutic ...target. M-CSF, however, accelerates forma- tion of osteoclasts by increasing ...
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Nuclear M-CSF Accelerates DNA Replication and Cell Proliferation in HeLa Human Cervical Cancer Cells
... cellular M-CSF. However, recent studies have shown that M-CSF can be expressed at a high level in the cytoplasm and nuclei of some kinds of malignant tumors, which related to the poor ...
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M CSF neutralization and Egr 1 deficiency prevent ovariectomy induced bone loss
... mice were either sham-operated or ovx. Sham-operat- ed mice were left untreated whereas ovx mice were treated with either irrelevant Ab, 5A1 Ab, or E2. All treatments were started the day of ovx and continued for 4 ...
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Serum levels of M-CSF, RANKL and OPG in rats fed with Kashin-Beck disease-affected diet
... ure, M-CSF/RANKL/OPG roles may be involved in the regulation of epiphyseal plate injury and repair in ...of M-CSF, RANKL and OPG were tested in order to evaluate their partici- pation in the ...
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Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M CSF signaling and osteoclast polarization
... modulated M-CSF–stimulated cyclin D expression and phosphorylation of Rb and induced caspase 3 and Bim, thus contributing to osteoclast proliferation and apoptosis ...multiple M-CSF– and ...
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M-CSF in a new biomarker panel with HE4 and CA 125 in the diagnostics of epithelial ovarian cancer patients
... when M-CSF was combined with conventional markers, sensitivity levels improved to 80% - stage I, to 92–100% in stages II-IV and to 91% or 96% in every histological sub-type of ...70%; M-CSF, ...
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M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia
... in M-CSF-directed mechanisms in tumors [62] and HIV infection ...the CSF-1R promoter in mam- malian cell line COS-7 cells [64], and could also be in- volved in the increase in CSF-1R ...
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Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over activation of PU 1/M CSF
... MO-secreted M-CSF is incited by changes in methylation level of SPII, or the acquisition of these features is part of broader tendency to acquire macrophage characteristic after severe ...
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The role of Src family kinases in mediating M CSF receptor signaling and monocytic cell survival
... of M-CSF (100 ng/ml) then incubated overnight at ...over M-CSF-stimulated sample readout per total protein and are expressed as the mean ± ...
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Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts
... by M-CSF alone and by M-CSF + RANKL, and we did not find consistent differences in the pro- tein levels of these molecules between the two monocyte sub- ...
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Effect of low-level laser therapy on bisphosphonate-treated osteoblasts
... and M-CSF secretions were mea- sured with an ELISA kit (Quantikine, R&D Systems, MN, USA), according to the manufacturer’s instruc- ...and M-CSF concentrations in each sample at 72 ...
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Macrophage colony stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
... anti- M-CSF antibody or anti-M-CSF receptor antibody was added either for the first 4 d or for the final 2 d, the MNC formation was similarly ...active M-CSF, the lack of ...
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Role for cFMS in maintaining alternative macrophage polarization in SIV infection: implications for HIV neuropathogenesis
... of M-CSF and IL-34, which also exerts its biological effects through the same M-CSF receptor, cFMS receptor tyrosine kinase, on rhesus macaque and human monocyte subset frequencies in ...ng/ml ...
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Granulocyte macrophage colony stimulating factor induces cytokine secretion by human polymorphonuclear leukocytes
... Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known as an inducer of proliferation and functional activation of myeloid cells. This study was carried out to characterize the effects of GM-CSF ...
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Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent
... Allo-MDM-conditioned medium induces reactivation of HCMV in monocytes. While the above experiments indicate that IFN-␥ is necessary for the production of virus in MDM, stimulation of cells with this cytokine alone was ...
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Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
... by M-CSF or RANKL has previ- ously been found to play essential roles in osteoclast precursor survival and proliferation and in osteoclast differentiation, respectively ...by M-CSF or RANKL ...
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Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
... and m-CSF are produced primarily by osteoblasts. m-CSF binds to its receptor c-FMS, expressed on osteoclast progenitors, and RANKL binds to its receptor on pre-osteoclasts to promote ...and ...
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Induction of junB expression, but not c jun, by granulocyte colony stimulating factor or macrophage colony stimulating factor in the proliferative response of human myeloid leukemia cells
... expression was constitutively observed at detectable levels. Furthermore, c-fos mRNA was rapidly induced to a peak of 14-fold after CSF stimulation. Transcriptional run-on assays revealed that treatment of ...
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IL-1 beta and TNF alpha Promote Monocyte Viability through the Induction of GM-CSF Expression by Rheumatoid Arthritis Synovial Fibroblasts
... Macrophages observed in the inflamed synovial tissue of RA patients represent a heterogeneous population composed of both pro- and anti-inflammatory cell subtypes [35]. Their specific polarization status might change ...
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Osteoclasts; culprits in inflammatory osteolysis
... of M-CSF. Like RANKL, M-CSF production by osteoblasts and their precursors, or by T cells, is stimulated by a variety of osteoclastogenic molecules, often with pathological ...of ...
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